Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles

In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell Death siRNA (CD-siRNA) for effective cancer treatment. The strategy takes advantage of the LDH anion exchange capacity to intercalate 5-FU i...

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Veröffentlicht in:	Biomaterials Jg. 35; H. 10; S. 3331 - 3339
Hauptverfasser:	Li, Li, Gu, Wenyi, Chen, Jiezhong, Chen, Weiyu, Xu, Zhi P.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Ltd 01.03.2014
Schlagworte:	Advanced Basic Science anion exchange capacity Antineoplastic Agents - administration & dosage Apoptosis Blotting, Western cell death Cell Line, Tumor Co-delivery system cytotoxicity Dentistry drug resistance Electrostatic assembly fluorouracil Humans Hydroxides - chemistry Layered double hydroxide mitochondria Nanoparticles neoplasms RNA, Small Interfering - administration & dosage small interfering RNA Co-delivery system Layered double hydroxide Electrostatic assembly Apoptosis
ISSN:	0142-9612, 1878-5905, 1878-5905
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Abstract	In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell Death siRNA (CD-siRNA) for effective cancer treatment. The strategy takes advantage of the LDH anion exchange capacity to intercalate 5-FU into its interlayer spacing and load siRNA on the surface of LDH nanoparticles. LDH nanoparticles have been previously demonstrated as an effective cellular delivery system for 5-FU and siRNA separately in various investigations. More excitedly, the combination of CD-siRNA and anticancer drug 5-FU with the same LDH particles significantly enhanced cytotoxicity to three cancer cell lines, e.g. MCF-7, U2OS and HCT-116, compared to the single treatment with either CD-siRNA or 5-FU. This enhancement is probably a result of coordinate mitochondrial damage process. Thus, the strategy to co-deliver siRNA and an anticancer drug by LDHs has great potential to overcome the drug resistance and enhance cancer treatment.
AbstractList	Abstract In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell Death siRNA (CD-siRNA) for effective cancer treatment. The strategy takes advantage of the LDH anion exchange capacity to intercalate 5-FU into its interlayer spacing and load siRNA on the surface of LDH nanoparticles. LDH nanoparticles have been previously demonstrated as an effective cellular delivery system for 5-FU and siRNA separately in various investigations. More excitedly, the combination of CD-siRNA and anticancer drug 5-FU with the same LDH particles significantly enhanced cytotoxicity to three cancer cell lines, e.g. MCF-7, U2OS and HCT-116, compared to the single treatment with either CD-siRNA or 5-FU. This enhancement is probably a result of coordinate mitochondrial damage process. Thus, the strategy to co-deliver siRNA and an anticancer drug by LDHs has great potential to overcome the drug resistance and enhance cancer treatment. In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell Death siRNA (CD-siRNA) for effective cancer treatment. The strategy takes advantage of the LDH anion exchange capacity to intercalate 5-FU into its interlayer spacing and load siRNA on the surface of LDH nanoparticles. LDH nanoparticles have been previously demonstrated as an effective cellular delivery system for 5-FU and siRNA separately in various investigations. More excitedly, the combination of CD-siRNA and anticancer drug 5-FU with the same LDH particles significantly enhanced cytotoxicity to three cancer cell lines, e.g. MCF-7, U2OS and HCT-116, compared to the single treatment with either CD-siRNA or 5-FU. This enhancement is probably a result of coordinate mitochondrial damage process. Thus, the strategy to co-deliver siRNA and an anticancer drug by LDHs has great potential to overcome the drug resistance and enhance cancer treatment.In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell Death siRNA (CD-siRNA) for effective cancer treatment. The strategy takes advantage of the LDH anion exchange capacity to intercalate 5-FU into its interlayer spacing and load siRNA on the surface of LDH nanoparticles. LDH nanoparticles have been previously demonstrated as an effective cellular delivery system for 5-FU and siRNA separately in various investigations. More excitedly, the combination of CD-siRNA and anticancer drug 5-FU with the same LDH particles significantly enhanced cytotoxicity to three cancer cell lines, e.g. MCF-7, U2OS and HCT-116, compared to the single treatment with either CD-siRNA or 5-FU. This enhancement is probably a result of coordinate mitochondrial damage process. Thus, the strategy to co-deliver siRNA and an anticancer drug by LDHs has great potential to overcome the drug resistance and enhance cancer treatment. In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell Death siRNA (CD-siRNA) for effective cancer treatment. The strategy takes advantage of the LDH anion exchange capacity to intercalate 5-FU into its interlayer spacing and load siRNA on the surface of LDH nanoparticles. LDH nanoparticles have been previously demonstrated as an effective cellular delivery system for 5-FU and siRNA separately in various investigations. More excitedly, the combination of CD-siRNA and anticancer drug 5-FU with the same LDH particles significantly enhanced cytotoxicity to three cancer cell lines, e.g. MCF-7, U2OS and HCT-116, compared to the single treatment with either CD-siRNA or 5-FU. This enhancement is probably a result of coordinate mitochondrial damage process. Thus, the strategy to co-deliver siRNA and an anticancer drug by LDHs has great potential to overcome the drug resistance and enhance cancer treatment.
Author	Li, Li Xu, Zhi P. Chen, Jiezhong Gu, Wenyi Chen, Weiyu
Author_xml	– sequence: 1 givenname: Li surname: Li fullname: Li, Li organization: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia – sequence: 2 givenname: Wenyi surname: Gu fullname: Gu, Wenyi email: w.gu@uq.edu.au organization: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia – sequence: 3 givenname: Jiezhong surname: Chen fullname: Chen, Jiezhong organization: School of Biomedical Sciences, University of Queensland, St Lucia, QLD 4072, Australia – sequence: 4 givenname: Weiyu surname: Chen fullname: Chen, Weiyu organization: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia – sequence: 5 givenname: Zhi P. surname: Xu fullname: Xu, Zhi P. email: gordonxu@uq.edu.au organization: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24456604$$D View this record in MEDLINE/PubMed
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Keywords	Co-delivery system Layered double hydroxide Electrostatic assembly Apoptosis
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Snippet	In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell... Abstract In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and...
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SubjectTerms	Advanced Basic Science anion exchange capacity Antineoplastic Agents - administration & dosage Apoptosis Blotting, Western cell death Cell Line, Tumor Co-delivery system cytotoxicity Dentistry drug resistance Electrostatic assembly fluorouracil Humans Hydroxides - chemistry Layered double hydroxide mitochondria Nanoparticles neoplasms RNA, Small Interfering - administration & dosage small interfering RNA
Title	Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S0142961213015913 https://www.clinicalkey.es/playcontent/1-s2.0-S0142961213015913 https://www.ncbi.nlm.nih.gov/pubmed/24456604 https://www.proquest.com/docview/1494310922 https://www.proquest.com/docview/2000220520
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