Nonsignificant associations between measures of inhibitory control and walking while thinking in persons with multiple sclerosis

To examine whether inhibitory control measures were associated with the dual-task cost (DTC) of walking in persons with multiple sclerosis (MS) and matched controls without MS. Cross-sectional study. University research laboratory. The sample (N=56) included ambulatory persons with relapsing-remitti...

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Veröffentlicht in:Archives of physical medicine and rehabilitation Jg. 96; H. 8; S. 1518
Hauptverfasser: Sandroff, Brian M, Benedict, Ralph H, Motl, Robert W
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.08.2015
Schlagworte:
Adult
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Multiple Sclerosis, Relapsing-Remitting - physiopathology
Task Performance and Analysis
Thinking - physiology
Walking - physiology
Walking
Executive function
Multiple sclerosis
Cognition
Rehabilitation
ISSN:1532-821X, 1532-821X
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Zusammenfassung:To examine whether inhibitory control measures were associated with the dual-task cost (DTC) of walking in persons with multiple sclerosis (MS) and matched controls without MS. Cross-sectional study. University research laboratory. The sample (N=56) included ambulatory persons with relapsing-remitting MS (n=28 [26 women, 2 men]; median Expanded Disability Status Scale score, 3.0) from the local community and controls (n=28) matched by age, sex, body mass index, and education. Not applicable. All participants underwent a modified flanker task followed by 4 trials of the timed 25-foot walk. The first 2 trials involved walking as quickly as possible only (single-task condition), and the second 2 trials involved walking as quickly as possible while naming alternate letters of the alphabet (dual-task condition). Walking speed under single- and dual-task conditions was used to compute a DTC of walking. Persons with MS demonstrated a similar DTC of walking compared with matched controls, but performed more poorly on inhibitory control measures. Interestingly, inhibitory control measures were not associated with DTC of walking in the MS sample (all |ρ|<.26, P>.19), but were associated with DTC of walking in controls (all |ρ|>.42, P<.03). Inhibitory control based on modified flanker performance might not be associated with DTC of walking in persons with MS.
Bibliographie:ObjectType-Article-1
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ISSN:1532-821X
1532-821X
DOI:10.1016/j.apmr.2015.04.015