Improving pediatric multiple sclerosis interventional phase III study design: a meta-analysis

Background: To support innovative trial designs in a regulatory setting for pediatric-onset multiple sclerosis (MS), the study aimed to perform a systematic literature review and meta-analysis of relapse rates with interferon β (IFN β), fingolimod, and natalizumab and thereby demonstrate potential b...

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Veröffentlicht in:	Therapeutic advances in neurological disorders Jg. 15; S. 17562864211070449
Hauptverfasser:	Graves, Jennifer S., Thomas, Marius, Li, Jun, Shah, Anuja R., Goodyear, Alexandra, Lange, Markus R., Schmidli, Heinz, Häring, Dieter A., Friede, Tim, Gärtner, Jutta
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London, England SAGE Publications 2022 SAGE PUBLICATIONS, INC SAGE Publishing
Schlagworte:	Bayesian analysis Clinical trials Interferon Literature reviews Meta-Analysis Monoclonal antibodies Multiple sclerosis Patients Pediatrics Quality control pediatric-onset multiple sclerosis annualized relapse rate fingolimod clinical trial design interferon systematic review natalizumab
ISSN:	1756-2864, 1756-2856, 1756-2864
Online-Zugang:	Volltext
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