New insights into the burden and costs of multiple sclerosis in Europe

The current focus in multiple sclerosis (MS) is on early diagnosis and drug intervention, with a view to modifying disease progression. Consequently, healthcare costs have shifted from inpatient care and rehabilitation to outpatient care. This European burden of illness study provides data that can...

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Vydáno v:Multiple sclerosis Ročník 23; číslo 8; s. 1123
Hlavní autoři: Kobelt, Gisela, Thompson, Alan, Berg, Jenny, Gannedahl, Mia, Eriksson, Jennifer
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 01.07.2017
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ISSN:1477-0970, 1477-0970
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Abstract The current focus in multiple sclerosis (MS) is on early diagnosis and drug intervention, with a view to modifying disease progression. Consequently, healthcare costs have shifted from inpatient care and rehabilitation to outpatient care. This European burden of illness study provides data that can be combined with other evidence to assess whether management approaches provide value to society. A cross-sectional study was conducted in 16 countries. Patients reported on their disease, health-related quality of life (HRQoL) and resource consumption. Descriptive analyses were performed by disease severity. Costs are reported from a societal perspective in 2015€ PPP (adjusted for purchasing power parity). The 16,808 participants had a mean age of 51.5 years, and 52% had relapsing-remitting multiple sclerosis (RRMS). Work capacity declined from 82% to 8%, and utility declined from normal population values to less than zero with advancing disease. Mean costs were 22,800€ PPP in mild, 37,100€ PPP in moderate and 57,500€ PPP in severe disease; healthcare accounted for 68%, 47% and 26%, respectively. Fatigue and cognitive difficulties were reported by 95% and 71% of participants, respectively; both had a significant independent effect on utility. Costs and utility were highly correlated with disease severity, but resource consumption was heavily influenced by healthcare systems organisation and availability of services.
AbstractList The current focus in multiple sclerosis (MS) is on early diagnosis and drug intervention, with a view to modifying disease progression. Consequently, healthcare costs have shifted from inpatient care and rehabilitation to outpatient care.BACKGROUNDThe current focus in multiple sclerosis (MS) is on early diagnosis and drug intervention, with a view to modifying disease progression. Consequently, healthcare costs have shifted from inpatient care and rehabilitation to outpatient care.This European burden of illness study provides data that can be combined with other evidence to assess whether management approaches provide value to society.OBJECTIVESThis European burden of illness study provides data that can be combined with other evidence to assess whether management approaches provide value to society.A cross-sectional study was conducted in 16 countries. Patients reported on their disease, health-related quality of life (HRQoL) and resource consumption. Descriptive analyses were performed by disease severity. Costs are reported from a societal perspective in 2015€ PPP (adjusted for purchasing power parity).METHODSA cross-sectional study was conducted in 16 countries. Patients reported on their disease, health-related quality of life (HRQoL) and resource consumption. Descriptive analyses were performed by disease severity. Costs are reported from a societal perspective in 2015€ PPP (adjusted for purchasing power parity).The 16,808 participants had a mean age of 51.5 years, and 52% had relapsing-remitting multiple sclerosis (RRMS). Work capacity declined from 82% to 8%, and utility declined from normal population values to less than zero with advancing disease. Mean costs were 22,800€ PPP in mild, 37,100€ PPP in moderate and 57,500€ PPP in severe disease; healthcare accounted for 68%, 47% and 26%, respectively. Fatigue and cognitive difficulties were reported by 95% and 71% of participants, respectively; both had a significant independent effect on utility.RESULTSThe 16,808 participants had a mean age of 51.5 years, and 52% had relapsing-remitting multiple sclerosis (RRMS). Work capacity declined from 82% to 8%, and utility declined from normal population values to less than zero with advancing disease. Mean costs were 22,800€ PPP in mild, 37,100€ PPP in moderate and 57,500€ PPP in severe disease; healthcare accounted for 68%, 47% and 26%, respectively. Fatigue and cognitive difficulties were reported by 95% and 71% of participants, respectively; both had a significant independent effect on utility.Costs and utility were highly correlated with disease severity, but resource consumption was heavily influenced by healthcare systems organisation and availability of services.CONCLUSIONCosts and utility were highly correlated with disease severity, but resource consumption was heavily influenced by healthcare systems organisation and availability of services.
The current focus in multiple sclerosis (MS) is on early diagnosis and drug intervention, with a view to modifying disease progression. Consequently, healthcare costs have shifted from inpatient care and rehabilitation to outpatient care. This European burden of illness study provides data that can be combined with other evidence to assess whether management approaches provide value to society. A cross-sectional study was conducted in 16 countries. Patients reported on their disease, health-related quality of life (HRQoL) and resource consumption. Descriptive analyses were performed by disease severity. Costs are reported from a societal perspective in 2015€ PPP (adjusted for purchasing power parity). The 16,808 participants had a mean age of 51.5 years, and 52% had relapsing-remitting multiple sclerosis (RRMS). Work capacity declined from 82% to 8%, and utility declined from normal population values to less than zero with advancing disease. Mean costs were 22,800€ PPP in mild, 37,100€ PPP in moderate and 57,500€ PPP in severe disease; healthcare accounted for 68%, 47% and 26%, respectively. Fatigue and cognitive difficulties were reported by 95% and 71% of participants, respectively; both had a significant independent effect on utility. Costs and utility were highly correlated with disease severity, but resource consumption was heavily influenced by healthcare systems organisation and availability of services.
Author Eriksson, Jennifer
Kobelt, Gisela
Berg, Jenny
Gannedahl, Mia
Thompson, Alan
Author_xml – sequence: 1
  givenname: Gisela
  surname: Kobelt
  fullname: Kobelt, Gisela
  organization: European Health Economics, Mulhouse, France
– sequence: 2
  givenname: Alan
  surname: Thompson
  fullname: Thompson, Alan
  organization: Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK
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  givenname: Jenny
  surname: Berg
  fullname: Berg, Jenny
  organization: Mapi Group, Stockholm, Sweden
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  surname: Gannedahl
  fullname: Gannedahl, Mia
  organization: Mapi Group, Stockholm, Sweden
– sequence: 5
  givenname: Jennifer
  surname: Eriksson
  fullname: Eriksson, Jennifer
  organization: Mapi Group, Stockholm, Sweden
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28273775$$D View this record in MEDLINE/PubMed
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Keywords costs
HRQoL
Multiple sclerosis
fatigue
cognition
burden of illness
Language English
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PublicationTitle Multiple sclerosis
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References 28504007 - Mult Scler. 2017 Jul;23(8):1048-1049
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Snippet The current focus in multiple sclerosis (MS) is on early diagnosis and drug intervention, with a view to modifying disease progression. Consequently,...
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SubjectTerms Adult
Ambulatory Care - economics
Cost of Illness
Disease Progression
Europe
Female
Health Care Costs - statistics & numerical data
Humans
Male
Middle Aged
Multiple Sclerosis - economics
Multiple Sclerosis - epidemiology
Multiple Sclerosis - therapy
Quality of Life
Recurrence
Severity of Illness Index
Title New insights into the burden and costs of multiple sclerosis in Europe
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