Immunohistochemical characterization of endometrial leucocytes in endometritis

Aims: Leucocytes are a normal and variable component of the endometrial stromal cell population. The aim of this study was to characterize endometrial leucocytes in established cases of endometritis in order to determine whether there are objective characteristics of the leucocyte infiltrate which...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Histopathology Ročník 45; číslo 6; s. 625 - 632
Hlavní autoři:	Disep, B, Innes, B A, Cochrane, H R, Tijani, S, Bulmer, J N
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Oxford, UK Blackwell Science Ltd 01.12.2004 Blackwell
Témata:	Antigens, CD - analysis Antigens, CD20 - analysis Antigens, Differentiation, Myelomonocytic - analysis Bacterial diseases Bacterial diseases of the genital system Biological and medical sciences CD3 Complex - analysis CD56 Antigen - analysis Cell Count endometrial leucocytes endometritis Endometritis - metabolism Endometritis - pathology Endometrium - pathology Female Human bacterial diseases human endometrium Humans Immunohistochemistry Infectious diseases Investigative techniques, diagnostic techniques (general aspects) Leukocyte Common Antigens - analysis Leukocytes - chemistry Leukocytes - pathology Leukosialin Macrophages - chemistry Macrophages - pathology Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Sialoglycoproteins - analysis T-Lymphocytes - chemistry T-Lymphocytes - pathology Characterization Human Immunohistochemistry Anatomic pathology Leukocyte endometrial leucocytes Female genital system human endometrium Uterine diseases Endometritis Endometrium Female genital diseases
ISSN:	0309-0167, 1365-2559
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Aims: Leucocytes are a normal and variable component of the endometrial stromal cell population. The aim of this study was to characterize endometrial leucocytes in established cases of endometritis in order to determine whether there are objective characteristics of the leucocyte infiltrate which would allow its identification as part of an inflammatory process rather then the normal physiological leucocyte infiltrate. Methods and results: We examined endometrial tissue from 79 cases of endometritis and 22 histologically normal controls. Leucocytes were characterized immunohistochemically for CD45, CD20, CD68, CD3 and CD56 and numbers were analysed semiquantitatively on a scale of 0–4. In many endometritis cases the overall number of leucocytes was increased. Furthermore, leucocytes were unusually distributed with a tendency to accumulate superficially beneath the endometrial surface. Whilst numbers of macrophages, T lymphocytes and endometrial granulated lymphocytes (uterine natural killer cells) did not differ between endometritis samples and controls, most endometritis cases contained a substantially increased number of B cells, which normally represent 1% or less of the endometrial leucocyte population. B lymphocytes were also observed in unusual locations such as intraepithelially and within glandular lumina. Conclusions: These results suggest that immunohistochemical characterization of endometrial leucocytes may be helpful in establishing a diagnosis of endometritis in equivocal cases.
Bibliografie:	ark:/67375/WNG-V7LN1CNC-P ArticleID:HIS2052 istex:DF25E18834829D4B94612BC09B5EC336A9883EDC ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0309-0167 1365-2559
DOI:	10.1111/j.1365-2559.2004.02052.x