Serum periostin relates to type‐2 inflammation and lung function in asthma: Data from the large population‐based cohort Swedish GA(2)LEN

Background Periostin has been suggested as a novel, phenotype‐specific biomarker for asthma driven by type 2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma re...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Allergy (Copenhagen) Ročník 72; číslo 11; s. 1753 - 1760
Hlavní autoři:	James, A., Janson, C., Malinovschi, A., Holweg, C., Alving, K., Ono, J., Ohta, S., Ek, A., Middelveld, R., Dahlén, B., Forsberg, B., Izuhara, K., Dahlén, S.‐E.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Denmark Blackwell Publishing Ltd 01.11.2017
Témata:	Adolescent Adult Aged Allergies Asthma Asthma - blood Asthma - epidemiology Asthma - pathology Asthma - physiopathology Biomarkers Body mass Body mass index Case-Control Studies Cell Adhesion Molecules - blood Enzyme-linked immunosorbent assay Eosinophil cationic protein Eosinophil-derived neurotoxin Humans Immunoglobulin E Inflammation Inflammation - etiology Lung - pathology Lung - physiopathology Lungs Middle Aged periostin Quality of life Respiratory function Rhinitis Rhinosinusitis Sinusitis Smoking Sweden Young Adult asthma rhinosinusitis periostin biomarkers
ISSN:	0105-4538, 1398-9995, 1398-9995
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Background Periostin has been suggested as a novel, phenotype‐specific biomarker for asthma driven by type 2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear. Aim To examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (CRS), in relation to other biomarkers and clinical characteristics. Methods Serum periostin was examined by ELISA in 1100 subjects aged 17‐76 from the Swedish Global Allergy and Asthma European Network (GA(2)LEN) study, which included 463 asthmatics with/without chronic rhinosinusitis (CRS), 98 individuals with CRS only, and 206 healthy controls. Clinical tests included measurement of lung function, Fraction of exhaled NO (FeNO), IgE, urinary eosinophil‐derived neurotoxin (U‐EDN), and serum eosinophil cationic protein (S‐ECP), as well as completion of questionnaires regarding respiratory symptoms, medication, and quality of life. Results Although median periostin values showed no differences when comparing disease groups with healthy controls, multiple regression analyses revealed that periostin was positively associated with higher FeNO, U‐EDN, and total IgE. In patients with asthma, an inverse relationship with lung function was also observed. Current smoking was associated with decreased periostin levels, whereas increased age and lower body mass index (BMI) related to higher periostin levels in subjects both with and without asthma. Conclusion We confirm associations between periostin and markers of type 2 inflammation, as well as lung function, and identify novel constitutional factors of importance to the use of periostin as a phenotype‐specific biomarker in asthma.
AbstractList	BackgroundPeriostin has been suggested as a novel, phenotype‐specific biomarker for asthma driven by type 2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear.AimTo examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (CRS), in relation to other biomarkers and clinical characteristics.MethodsSerum periostin was examined by ELISA in 1100 subjects aged 17‐76 from the Swedish Global Allergy and Asthma European Network (GA(2)LEN) study, which included 463 asthmatics with/without chronic rhinosinusitis (CRS), 98 individuals with CRS only, and 206 healthy controls. Clinical tests included measurement of lung function, Fraction of exhaled NO (FeNO), IgE, urinary eosinophil‐derived neurotoxin (U‐EDN), and serum eosinophil cationic protein (S‐ECP), as well as completion of questionnaires regarding respiratory symptoms, medication, and quality of life.ResultsAlthough median periostin values showed no differences when comparing disease groups with healthy controls, multiple regression analyses revealed that periostin was positively associated with higher FeNO, U‐EDN, and total IgE. In patients with asthma, an inverse relationship with lung function was also observed. Current smoking was associated with decreased periostin levels, whereas increased age and lower body mass index (BMI) related to higher periostin levels in subjects both with and without asthma.ConclusionWe confirm associations between periostin and markers of type 2 inflammation, as well as lung function, and identify novel constitutional factors of importance to the use of periostin as a phenotype‐specific biomarker in asthma. Periostin has been suggested as a novel, phenotype-specific biomarker for asthma driven by type 2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear.BACKGROUNDPeriostin has been suggested as a novel, phenotype-specific biomarker for asthma driven by type 2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear.To examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (CRS), in relation to other biomarkers and clinical characteristics.AIMTo examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (CRS), in relation to other biomarkers and clinical characteristics.Serum periostin was examined by ELISA in 1100 subjects aged 17-76 from the Swedish Global Allergy and Asthma European Network (GA(2)LEN) study, which included 463 asthmatics with/without chronic rhinosinusitis (CRS), 98 individuals with CRS only, and 206 healthy controls. Clinical tests included measurement of lung function, Fraction of exhaled NO (FeNO), IgE, urinary eosinophil-derived neurotoxin (U-EDN), and serum eosinophil cationic protein (S-ECP), as well as completion of questionnaires regarding respiratory symptoms, medication, and quality of life.METHODSSerum periostin was examined by ELISA in 1100 subjects aged 17-76 from the Swedish Global Allergy and Asthma European Network (GA(2)LEN) study, which included 463 asthmatics with/without chronic rhinosinusitis (CRS), 98 individuals with CRS only, and 206 healthy controls. Clinical tests included measurement of lung function, Fraction of exhaled NO (FeNO), IgE, urinary eosinophil-derived neurotoxin (U-EDN), and serum eosinophil cationic protein (S-ECP), as well as completion of questionnaires regarding respiratory symptoms, medication, and quality of life.Although median periostin values showed no differences when comparing disease groups with healthy controls, multiple regression analyses revealed that periostin was positively associated with higher FeNO, U-EDN, and total IgE. In patients with asthma, an inverse relationship with lung function was also observed. Current smoking was associated with decreased periostin levels, whereas increased age and lower body mass index (BMI) related to higher periostin levels in subjects both with and without asthma.RESULTSAlthough median periostin values showed no differences when comparing disease groups with healthy controls, multiple regression analyses revealed that periostin was positively associated with higher FeNO, U-EDN, and total IgE. In patients with asthma, an inverse relationship with lung function was also observed. Current smoking was associated with decreased periostin levels, whereas increased age and lower body mass index (BMI) related to higher periostin levels in subjects both with and without asthma.We confirm associations between periostin and markers of type 2 inflammation, as well as lung function, and identify novel constitutional factors of importance to the use of periostin as a phenotype-specific biomarker in asthma.CONCLUSIONWe confirm associations between periostin and markers of type 2 inflammation, as well as lung function, and identify novel constitutional factors of importance to the use of periostin as a phenotype-specific biomarker in asthma. Background: Periostin has been suggested as a novel, phenotype-specific biomarker for asthma driven by type-2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear. Aim: To examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (CRS), in relation to other biomarkers and clinical characteristics. Methods: Serum periostin was examined by ELISA in 1091 subjects aged 17-76 from the Swedish GA(2)LEN study, which included 460 asthmatics with/without chronic rhinosinusitis (CRS), 97 individuals with CRS only, and 203 healthy controls. Clinical tests included measurement of lung function, FeNO, IgE, urinary eosinophil derived neurotoxin (U-EDN) and serum eosinophil cationic protein (S-ECP), as well as completion of questionnaires regarding respiratory symptoms, medication and quality of life. Results: Although median periostin values showed no differences when comparing disease groups with healthy controls, multiple regression analyses revealed that periostin was positively associated with higher FeNO, U-EDN and total IgE. In patients with asthma, an inverse relationship with lung function was also observed. Current smoking was associated with decreased periostin levels, whereas increased age and lower BMI related to higher periostin levels in subjects both with and without asthma. Conclusion: We confirm associations between periostin and markers of type-2 inflammation, as well as lung function, and identify novel constitutional factors of importance to the use of periostin as a phenotype-specific biomarker in asthma. Background Periostin has been suggested as a novel, phenotype‐specific biomarker for asthma driven by type 2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear. Aim To examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (CRS), in relation to other biomarkers and clinical characteristics. Methods Serum periostin was examined by ELISA in 1100 subjects aged 17‐76 from the Swedish Global Allergy and Asthma European Network (GA(2)LEN) study, which included 463 asthmatics with/without chronic rhinosinusitis (CRS), 98 individuals with CRS only, and 206 healthy controls. Clinical tests included measurement of lung function, Fraction of exhaled NO (FeNO), IgE, urinary eosinophil‐derived neurotoxin (U‐EDN), and serum eosinophil cationic protein (S‐ECP), as well as completion of questionnaires regarding respiratory symptoms, medication, and quality of life. Results Although median periostin values showed no differences when comparing disease groups with healthy controls, multiple regression analyses revealed that periostin was positively associated with higher FeNO, U‐EDN, and total IgE. In patients with asthma, an inverse relationship with lung function was also observed. Current smoking was associated with decreased periostin levels, whereas increased age and lower body mass index (BMI) related to higher periostin levels in subjects both with and without asthma. Conclusion We confirm associations between periostin and markers of type 2 inflammation, as well as lung function, and identify novel constitutional factors of importance to the use of periostin as a phenotype‐specific biomarker in asthma. Periostin has been suggested as a novel, phenotype-specific biomarker for asthma driven by type 2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking and the suitability of periostin as a biomarker in asthma remains unclear. To examine circulating periostin in healthy controls and subjects with asthma from the general population with different severity and treatment profiles, both with and without chronic rhinosinusitis (CRS), in relation to other biomarkers and clinical characteristics. Serum periostin was examined by ELISA in 1100 subjects aged 17-76 from the Swedish Global Allergy and Asthma European Network (GA(2)LEN) study, which included 463 asthmatics with/without chronic rhinosinusitis (CRS), 98 individuals with CRS only, and 206 healthy controls. Clinical tests included measurement of lung function, Fraction of exhaled NO (FeNO), IgE, urinary eosinophil-derived neurotoxin (U-EDN), and serum eosinophil cationic protein (S-ECP), as well as completion of questionnaires regarding respiratory symptoms, medication, and quality of life. Although median periostin values showed no differences when comparing disease groups with healthy controls, multiple regression analyses revealed that periostin was positively associated with higher FeNO, U-EDN, and total IgE. In patients with asthma, an inverse relationship with lung function was also observed. Current smoking was associated with decreased periostin levels, whereas increased age and lower body mass index (BMI) related to higher periostin levels in subjects both with and without asthma. We confirm associations between periostin and markers of type 2 inflammation, as well as lung function, and identify novel constitutional factors of importance to the use of periostin as a phenotype-specific biomarker in asthma.
Author	Dahlén, B. Holweg, C. James, A. Izuhara, K. Malinovschi, A. Ek, A. Ohta, S. Janson, C. Ono, J. Alving, K. Dahlén, S.‐E. Middelveld, R. Forsberg, B.
Author_xml	– sequence: 1 givenname: A. orcidid: 0000-0003-2698-8419 surname: James fullname: James, A. email: anna.james@ki.se organization: Karolinska Institutet – sequence: 2 givenname: C. surname: Janson fullname: Janson, C. organization: Uppsala University – sequence: 3 givenname: A. surname: Malinovschi fullname: Malinovschi, A. organization: Uppsala University – sequence: 4 givenname: C. surname: Holweg fullname: Holweg, C. organization: Genentech Inc – sequence: 5 givenname: K. surname: Alving fullname: Alving, K. organization: Uppsala University – sequence: 6 givenname: J. surname: Ono fullname: Ono, J. organization: Shino‐test Corporation Ltd – sequence: 7 givenname: S. surname: Ohta fullname: Ohta, S. organization: Saga Medical School – sequence: 8 givenname: A. surname: Ek fullname: Ek, A. organization: Karolinska Institutet – sequence: 9 givenname: R. surname: Middelveld fullname: Middelveld, R. organization: Karolinska Institutet – sequence: 10 givenname: B. surname: Dahlén fullname: Dahlén, B. organization: Karolinska Institutet and Karolinska University Hospital Huddinge – sequence: 11 givenname: B. surname: Forsberg fullname: Forsberg, B. organization: Umeå University – sequence: 12 givenname: K. surname: Izuhara fullname: Izuhara, K. organization: Saga Medical School – sequence: 13 givenname: S.‐E. surname: Dahlén fullname: Dahlén, S.‐E. organization: Karolinska Institutet
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28398635$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133629$$DView record from Swedish Publication Index (Umeå universitet) https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-339737$$DView record from Swedish Publication Index (Uppsala universitet) http://kipublications.ki.se/Default.aspx?queryparsed=id:136864857$$DView record from Swedish Publication Index (Karolinska Institutet)
BookMark	eNp9kstuEzEUhi1URC-w4AWQJTatxLS-jDNjdlFbClIEiwJby5k5k7h4xlNfFGXHA7DgGXkS3CQUqVLrja2j7_9knXMO0d7gBkDoNSWnNJ8zbe0p5bSmz9AB5bIupJRiDx0QSkRRCl7vo8MQbgghFZPkBdpndaYmXBygX9fgU49H8MaFaAbsweoIAUeH43qEPz9_M2yGzuq-19G4AeuhxTYNC9ylodlUckqHuOz1e3yho8addz2OS8BW-wXg0Y3JbrJZNtcBWty4pfMRX6-gNWGJr6bH7GR2-fklet5pG-DV7j5C3z5cfj3_WMy-XH06n86KRnBGCy4FYZrrStSsA5i3QHlb8bamNQPS0rkAyaGTpcjNKduaTcqq0uWEyZLQdlLyI1RsvWEFY5qr0Zte-7Vy2qhd6Ud-gSpllVOZf_cof2G-T5XzC5WS4lxWvHpS_x_vk6Kcb_XHW3707jZBiKo3oQFr9QAuBUXrelIJKuSd-u0D9MYlP-RmKSoFLSkVJcvUmx2V5j209x_4N_YMnGyBxrsQPHT3CCXqbqVUXim1WanMnj1gGxM344xeG_tUYmUsrB9Xq-lstk38BS5I3fs
CitedBy_id	crossref_primary_10_1080_02770903_2019_1684518 crossref_primary_10_4168_aair_2018_10_6_716 crossref_primary_10_3389_fmed_2023_1276900 crossref_primary_10_1111_all_15216 crossref_primary_10_1016_j_resinv_2020_02_003 crossref_primary_10_1002_alr_23018 crossref_primary_10_1007_s00018_017_2649_z crossref_primary_10_1186_s12931_023_02323_7 crossref_primary_10_1186_s40733_018_0047_4 crossref_primary_10_1159_000530703 crossref_primary_10_1007_s00005_018_0526_6 crossref_primary_10_3390_antiox11112256 crossref_primary_10_1177_19458924251332546 crossref_primary_10_1016_j_iac_2018_06_008 crossref_primary_10_1016_j_iac_2018_06_004 crossref_primary_10_2147_JAA_S496020 crossref_primary_10_1111_all_13967 crossref_primary_10_1183_23120541_00347_2019 crossref_primary_10_1111_cea_13367 crossref_primary_10_1159_000501224 crossref_primary_10_1016_j_rmed_2018_08_005 crossref_primary_10_1177_2058738421990493 crossref_primary_10_1097_ACI_0000000000000599 crossref_primary_10_1111_cea_13165 crossref_primary_10_1177_00045632221106068 crossref_primary_10_1080_02770903_2018_1471708 crossref_primary_10_1080_02770903_2020_1766061 crossref_primary_10_1111_pai_13329 crossref_primary_10_1111_cea_13759 crossref_primary_10_1016_j_chemosphere_2022_134277 crossref_primary_10_1111_all_13814 crossref_primary_10_3390_ijms23084086 crossref_primary_10_13005_bpj_2461 crossref_primary_10_1016_j_smim_2019_101333 crossref_primary_10_3389_fimmu_2023_1201160 crossref_primary_10_1111_all_14032 crossref_primary_10_1016_j_rmed_2022_107089 crossref_primary_10_1007_s00018_017_2648_0 crossref_primary_10_3390_biom11081084 crossref_primary_10_1007_s00018_018_2899_4 crossref_primary_10_18332_tid_156047 crossref_primary_10_1186_s13601_018_0238_3 crossref_primary_10_1371_journal_pone_0281356 crossref_primary_10_3389_fmed_2023_1129300 crossref_primary_10_1080_02770903_2018_1455855 crossref_primary_10_1111_cea_13302 crossref_primary_10_1111_all_13628 crossref_primary_10_1007_s11882_017_0739_5 crossref_primary_10_1080_02770903_2020_1786111 crossref_primary_10_1080_08923973_2020_1824238 crossref_primary_10_3390_jcm12165404 crossref_primary_10_1186_s13601_019_0258_7
Cites_doi	10.1073/pnas.0707413104 10.1016/j.jaci.2014.12.1871 10.1046/j.1365-2222.2001.01022.x 10.1111/j.1398-9995.2011.02709.x 10.1034/j.1398-9995.2000.00858.x 10.1378/chest.104.2.600 10.1016/j.jaci.2015.11.020 10.1111/resp.12687 10.1016/S0091-6749(96)70182-3 10.1016/0168-8510(90)90421-9 10.1034/j.1399-3003.1999.14a08.x 10.1186/s12890-016-0230-4 10.1016/j.jaci.2013.04.050 10.1016/j.jaci.2006.02.046 10.1016/j.jaci.2012.06.025 10.1002/alr.21056 10.2332/allergolint.11-OA-0370 10.1183/13993003.01384-2015 10.4137/JCM.S5899 10.1002/jcb.21224 10.1093/rheumatology/kev410 10.2500/aap.2016.37.3945 10.1016/j.jaci.2015.12.1346 10.1073/pnas.1009426107 10.1016/j.rmed.2015.03.009 10.1136/thoraxjnl-2014-205634 10.1016/j.alit.2014.07.003 10.1016/j.jaci.2011.11.035 10.1359/jbmr.2000.15.2.322 10.1183/09031936.00059810 10.1056/NEJMoa1106469 10.1111/all.12222 10.1111/cea.12763 10.1016/j.clinbiochem.2016.10.002
ContentType	Journal Article
Copyright	2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Copyright_xml	– notice: 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. – notice: Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7T5 H94 K9. 7X8 ADTPV AOWAS D93 DF2
DOI	10.1111/all.13181
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic SwePub SwePub Articles SWEPUB Umeå universitet SWEPUB Uppsala universitet
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts MEDLINE - Academic
DatabaseTitleList	AIDS and Cancer Research Abstracts MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1398-9995
EndPage	1760
ExternalDocumentID	oai_swepub_ki_se_497629 oai_DiVA_org_uu_339737 oai_DiVA_org_umu_133629 28398635 10_1111_all_13181 ALL13181
Genre	article Journal Article
GrantInformation_xml	– fundername: Vårdal Foundation – fundername: Stockholm County Council – fundername: Swedish Foundation for Strategic Research – fundername: EU FP6 project GA(2)LEN funderid: FOOD‐CT‐2004‐506378 – fundername: Swedish Asthma and Allergy Association – fundername: Swedish Heart Lung Foundation – fundername: Konsul Th C Berghs Foundation – fundername: Karolinska Institutet – fundername: Karolinska Institutet SciLifeLab Collaborations on Translational Medicine (ChAMP) – fundername: Swedish Research Council
GroupedDBID	.3N .GA .GJ .Y3 05W 0R~ 10A 1OB 1OC 23M 2WC 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8F7 8UM 930 A01 A03 AAESR AAEVG AAHQN AAIPD AAKAS AAMMB AAMNL AANHP AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABJNI ABLJU ABOCM ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZCM ADZMN AEFGJ AEIGN AEIMD AENEX AEUYR AEYWJ AFBPY AFEBI AFFNX AFFPM AFGKR AFRAH AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHEFC AHMBA AIACR AIDQK AIDYY AITYG AIURR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB AOETA ATUGU AZBYB AZFZN AZVAB BAFTC BAWUL BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DC6 DCZOG DPXWK DR2 DRFUL DRMAN DRSTM E3Z EBS EJD EMOBN EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OK1 OVD P2P P2W P2X P2Z P4B P4D P6G PALCI PQQKQ Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ TEORI TR2 UB1 V9Y W8V W99 WBKPD WHWMO WIH WIJ WIK WIN WOHZO WOW WQJ WVDHM WXI WXSBR XG1 Y6R ZGI ZXP ZZTAW ~IA ~KM ~WT AAYXX AIQQE CITATION O8X AAHHS ACCFJ AEEZP AEQDE AIWBW AJBDE CGR CUY CVF ECM EIF NPM 7T5 H94 K9. 7X8 ADTPV AOWAS D93 DF2
ID	FETCH-LOGICAL-c5321-39502a3a7582feebde13d73d8182e0d1b5e93ef9451114d826477a4629401d643
IEDL.DBID	WIN
ISICitedReferencesCount	60
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000413151200015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0105-4538 1398-9995
IngestDate	Tue Nov 25 03:27:39 EST 2025 Tue Nov 04 16:43:59 EST 2025 Tue Nov 04 17:00:33 EST 2025 Fri Jul 11 08:23:14 EDT 2025 Fri Oct 03 08:22:04 EDT 2025 Thu Apr 03 07:11:42 EDT 2025 Sat Nov 29 06:24:50 EST 2025 Tue Nov 18 21:43:03 EST 2025 Wed Aug 20 07:25:52 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Issue	11
Keywords	asthma rhinosinusitis periostin biomarkers
Language	English
License	http://onlinelibrary.wiley.com/termsAndConditions#vor 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c5321-39502a3a7582feebde13d73d8182e0d1b5e93ef9451114d826477a4629401d643
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0003-2698-8419
PMID	28398635
PQID	1951411542
PQPubID	34098
PageCount	8
ParticipantIDs	swepub_primary_oai_swepub_ki_se_497629 swepub_primary_oai_DiVA_org_uu_339737 swepub_primary_oai_DiVA_org_umu_133629 proquest_miscellaneous_1886751597 proquest_journals_1951411542 pubmed_primary_28398635 crossref_primary_10_1111_all_13181 crossref_citationtrail_10_1111_all_13181 wiley_primary_10_1111_all_13181_ALL13181
PublicationCentury	2000
PublicationDate	November 2017
PublicationDateYYYYMMDD	2017-11-01
PublicationDate_xml	– month: 11 year: 2017 text: November 2017
PublicationDecade	2010
PublicationPlace	Denmark
PublicationPlace_xml	– name: Denmark – name: Zurich
PublicationTitle	Allergy (Copenhagen)
PublicationTitleAlternate	Allergy
PublicationYear	2017
Publisher	Blackwell Publishing Ltd
Publisher_xml	– name: Blackwell Publishing Ltd
References	2012; 61 2007; 104 2007; 101 2010; 107 2015; 70 1990; 16 2013; 68 2015; 109 2011; 37 2006; 118 2016; 16 2016; 37 1993; 104 2012; 129 1996; 97 2016; 55 2017; 50 2012; 130 2012; 2 2012; 3 2010; 1 2000; 15 2015; 135 2015; 64 2000; 55 1999; 14 2016; 21 2016; 138 2016; 137 2013; 132 2012; 67 2011; 365 2016; 47 2016; 46 2001; 31 e_1_2_8_28_1 e_1_2_8_29_1 e_1_2_8_24_1 e_1_2_8_25_1 e_1_2_8_26_1 e_1_2_8_27_1 e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_20_1 e_1_2_8_21_1 e_1_2_8_22_1 e_1_2_8_23_1 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_15_1 e_1_2_8_16_1 Fokkens WJ (e_1_2_8_12_1) 2012; 3 e_1_2_8_32_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_33_1 e_1_2_8_30_1
References_xml	– volume: 107 start-page: 14170 year: 2010 end-page: 14175 article-title: Roles of epithelial cell‐derived periostin in TGF‐beta activation, collagen production, and collagen gel elasticity in asthma publication-title: Proc Natl Acad Sci USA – volume: 37 start-page: 1119 year: 2011 end-page: 1127 article-title: Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias publication-title: Eur Respir J – volume: 109 start-page: 708 year: 2015 end-page: 715 article-title: Serum periostin in smokers and never smokers with asthma publication-title: Respir Med – volume: 365 start-page: 1088 year: 2011 end-page: 1098 article-title: Lebrikizumab treatment in adults with asthma publication-title: N Engl J Med – volume: 3 start-page: 1 year: 2012 end-page: 298 article-title: European Position Paper on Rhinosinusitis and Nasal Polyps 2012 publication-title: Rhinol Suppl – volume: 31 start-page: 400 year: 2001 end-page: 408 article-title: Benefits of high altitude allergen avoidance in atopic adolescents with moderate to severe asthma, over and above treatment with high dose inhaled steroids publication-title: Clin Exp Allergy – volume: 132 start-page: 305 year: 2013 end-page: 312 article-title: Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids publication-title: J Allergy Clin Immunol – volume: 55 start-page: 1203 year: 2000 end-page: 1204 article-title: Increased END/EPX in ongoing asthma publication-title: Allergy – volume: 50 start-page: 139 year: 2017 end-page: 144 article-title: Multicenter evaluation of analytical characteristics of the Elecsys Periostin immunoassay publication-title: Clin Biochem – volume: 2 start-page: 471 year: 2012 end-page: 476 article-title: Expression of the extracellular matrix gene periostin is increased in chronic rhinosinusitis and decreases following successful endoscopic sinus surgery publication-title: Int Forum Allergy Rhinol – volume: 1 start-page: 13 year: 2010 end-page: 20 article-title: Novel isoforms of periostin expressed in the human thyroid publication-title: Jpn Clin Med – volume: 16 start-page: 199 year: 1990 end-page: 208 article-title: EuroQol‐a new facility for the measurement of health‐related quality of life publication-title: Health Policy – volume: 46 start-page: 1303 year: 2016 end-page: 1314 article-title: Periostin Study Team. Reference ranges for serum periostin in a population without asthma or chronic obstructive pulmonary disease publication-title: Clin Exp Allergy – volume: 68 start-page: 1314 year: 2013 end-page: 1321 article-title: Chronic rhinosinusitis in asthma is a negative predictor of quality of life: results from the Swedish GA(2)LEN survey publication-title: Allergy – volume: 130 start-page: 647 year: 2012 end-page: 654 article-title: Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients publication-title: J Allergy Clin Immunol – volume: 14 start-page: 32 year: 1999 end-page: 38 article-title: Development and validation of the mini asthma quality of life questionnaire publication-title: Eur Respir J – volume: 101 start-page: 695 year: 2007 end-page: 711 article-title: Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues publication-title: J Cell Biochem – volume: 104 start-page: 600 year: 1993 end-page: 608 article-title: Asthma and asthma‐like symptoms in adults assessed by questionnaires. A literature review publication-title: Chest – volume: 67 start-page: 91 year: 2012 end-page: 98 article-title: Asthma in adults and its association with chronic rhinosinusitis: the GA(2)LEN survey in Europe publication-title: Allergy – volume: 16 start-page: 67 year: 2016 article-title: Periostin levels and eosinophilic inflammation in poorly‐controlled asthma publication-title: BMC Pulm Med – volume: 64 start-page: 175 year: 2015 end-page: 180 article-title: Phenotype of asthma related with high serum periostin levels publication-title: Allergol Int – volume: 70 start-page: 115 year: 2015 end-page: 120 article-title: External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma publication-title: Thorax – volume: 104 start-page: 15858 year: 2007 end-page: 15863 article-title: Genome‐wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids publication-title: Proc Natl Acad Sci USA – volume: 15 start-page: 322 year: 2000 end-page: 331 article-title: Osteoporosis in elderly men and women: effects of dietary calcium, physical activity, and body mass index publication-title: J Bone Miner Res – volume: 61 start-page: 589 year: 2012 end-page: 595 article-title: Expression of pendrin and periostin in allergic rhinitis and chronic rhinosinusitis publication-title: Allergol Int – volume: 37 start-page: 225 year: 2016 end-page: 230 article-title: Association of airway wall thickness with serum periostin in steroid‐naive asthma publication-title: Allergy Asthma Proc – volume: 129 start-page: 990 year: 2012 end-page: 997 article-title: Airway epithelial cells from asthmatic children differentially express proremodeling factors publication-title: J Allergy Clin Immunol – volume: 47 start-page: 1383 year: 2016 end-page: 1391 article-title: Serum periostin in obstructive airways disease publication-title: Eur Respir J – volume: 138 start-page: 61 year: 2016 end-page: 75 article-title: Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3‐like protein 1 publication-title: J Allergy Clin Immunol – volume: 118 start-page: 98 year: 2006 end-page: 104 article-title: Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL‐4 and IL‐13 signals publication-title: J Allergy Clin Immunol – volume: 21 start-page: 297 year: 2016 end-page: 303 article-title: Effect of treatment with inhaled corticosteroid on serum periostin levels in asthma publication-title: Respirology – volume: 135 start-page: 299 year: 2015 end-page: 310 article-title: Asthma phenotypes and the use of biologic medications in asthma and allergic disease: the next steps toward personalized care publication-title: J Allergy Clin Immunol – volume: 97 start-page: 1179 year: 1996 end-page: 1187 article-title: Urinary eosinophil protein X in children with atopic asthma: a useful marker of antiinflammatory treatment publication-title: J Allergy Clin Immunol – volume: 55 start-page: 1714 year: 2016 end-page: 1725 article-title: Novel biological markers of bone: from bone metabolism to bone physiology publication-title: Rheumatology – volume: 137 start-page: 1904 year: 2016 end-page: 1907 article-title: Serum periostin is associated with type 2 immunity in severe asthma publication-title: J Allergy Clin Immunol – ident: e_1_2_8_5_1 doi: 10.1073/pnas.0707413104 – ident: e_1_2_8_7_1 doi: 10.1016/j.jaci.2014.12.1871 – ident: e_1_2_8_28_1 doi: 10.1046/j.1365-2222.2001.01022.x – ident: e_1_2_8_11_1 doi: 10.1111/j.1398-9995.2011.02709.x – ident: e_1_2_8_27_1 doi: 10.1034/j.1398-9995.2000.00858.x – ident: e_1_2_8_36_1 doi: 10.1378/chest.104.2.600 – ident: e_1_2_8_26_1 doi: 10.1016/j.jaci.2015.11.020 – ident: e_1_2_8_33_1 doi: 10.1111/resp.12687 – ident: e_1_2_8_29_1 doi: 10.1016/S0091-6749(96)70182-3 – ident: e_1_2_8_13_1 doi: 10.1016/0168-8510(90)90421-9 – ident: e_1_2_8_14_1 doi: 10.1034/j.1399-3003.1999.14a08.x – ident: e_1_2_8_25_1 doi: 10.1186/s12890-016-0230-4 – ident: e_1_2_8_30_1 doi: 10.1016/j.jaci.2013.04.050 – ident: e_1_2_8_4_1 doi: 10.1016/j.jaci.2006.02.046 – ident: e_1_2_8_9_1 doi: 10.1016/j.jaci.2012.06.025 – ident: e_1_2_8_19_1 doi: 10.1002/alr.21056 – ident: e_1_2_8_18_1 doi: 10.2332/allergolint.11-OA-0370 – ident: e_1_2_8_21_1 doi: 10.1183/13993003.01384-2015 – ident: e_1_2_8_34_1 doi: 10.4137/JCM.S5899 – ident: e_1_2_8_31_1 doi: 10.1002/jcb.21224 – ident: e_1_2_8_2_1 doi: 10.1093/rheumatology/kev410 – ident: e_1_2_8_32_1 doi: 10.2500/aap.2016.37.3945 – ident: e_1_2_8_22_1 doi: 10.1016/j.jaci.2015.12.1346 – ident: e_1_2_8_3_1 doi: 10.1073/pnas.1009426107 – ident: e_1_2_8_23_1 doi: 10.1016/j.rmed.2015.03.009 – ident: e_1_2_8_8_1 doi: 10.1136/thoraxjnl-2014-205634 – ident: e_1_2_8_24_1 doi: 10.1016/j.alit.2014.07.003 – ident: e_1_2_8_17_1 doi: 10.1016/j.jaci.2011.11.035 – volume: 3 start-page: 1 year: 2012 ident: e_1_2_8_12_1 article-title: European Position Paper on Rhinosinusitis and Nasal Polyps 2012 publication-title: Rhinol Suppl – ident: e_1_2_8_35_1 doi: 10.1359/jbmr.2000.15.2.322 – ident: e_1_2_8_15_1 doi: 10.1183/09031936.00059810 – ident: e_1_2_8_6_1 doi: 10.1056/NEJMoa1106469 – ident: e_1_2_8_10_1 doi: 10.1111/all.12222 – ident: e_1_2_8_20_1 doi: 10.1111/cea.12763 – ident: e_1_2_8_16_1 doi: 10.1016/j.clinbiochem.2016.10.002
SSID	ssj0007290
Score	2.4652967
Snippet	Background Periostin has been suggested as a novel, phenotype‐specific biomarker for asthma driven by type 2 inflammation. However, large studies examining... Periostin has been suggested as a novel, phenotype-specific biomarker for asthma driven by type 2 inflammation. However, large studies examining relationships... BackgroundPeriostin has been suggested as a novel, phenotype‐specific biomarker for asthma driven by type 2 inflammation. However, large studies examining... Background: Periostin has been suggested as a novel, phenotype-specific biomarker for asthma driven by type-2 inflammation. However, large studies examining... Background Periostin has been suggested as a novel, phenotype-specific biomarker for asthma driven by type 2 inflammation. However, large studies examining...
SourceID	swepub proquest pubmed crossref wiley
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	1753
SubjectTerms	Adolescent Adult Aged Allergies Asthma Asthma - blood Asthma - epidemiology Asthma - pathology Asthma - physiopathology Biomarkers Body mass Body mass index Case-Control Studies Cell Adhesion Molecules - blood Enzyme-linked immunosorbent assay Eosinophil cationic protein Eosinophil-derived neurotoxin Humans Immunoglobulin E Inflammation Inflammation - etiology Lung - pathology Lung - physiopathology Lungs Middle Aged periostin Quality of life Respiratory function Rhinitis Rhinosinusitis Sinusitis Smoking Sweden Young Adult
Title	Serum periostin relates to type‐2 inflammation and lung function in asthma: Data from the large population‐based cohort Swedish GA(2)LEN
URI	https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fall.13181 https://www.ncbi.nlm.nih.gov/pubmed/28398635 https://www.proquest.com/docview/1951411542 https://www.proquest.com/docview/1886751597 https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133629 https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-339737 http://kipublications.ki.se/Default.aspx?queryparsed=id:136864857
Volume	72
WOSCitedRecordID	wos000413151200015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVWIB databaseName: Wiley Online Library Free Content customDbUrl: eissn: 1398-9995 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0007290 issn: 1398-9995 databaseCode: WIN dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Full Collection 2020 customDbUrl: eissn: 1398-9995 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0007290 issn: 1398-9995 databaseCode: DRFUL dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpZ3NjpRAEIAr62qMF_9_0HXSGjXjAQPdzDboaeLsqAlOjLrr3Eg3NO5GBjYD6NUH8OAz-iRWNQxx42pMvBEomgaqur9qqCqABybNZSR16Ko02nUpVNPVqchcT0faS70w78LHDmK5WITLZfRmC55tYmG6_BDDghtZhh2vycCVrn8xclUUT3zUSHJ9_MCn6gUfXi2GUVj26yvID26AVt1nFaK_eIYzT85FvwHmkD30JLjamWd-6b_6fBku9sDJpp2GXIEtU16F86_7T-rX4BuOFu2KUcLjCs29ZDa6xdSsqRitz_74-p0zVEPUnC7KkakyYwWOEYzmRLsHz1J1c7hST9lMNYpRzApDsmQF_WfOjociYdgYTZsZo7q864a9-0JhwYfsxXTMH8d7i-uwP997__yl25docNOJ4L4roonHlVDodfDcGJ0ZX2RSZIgB3HiZrycmEiaPKAuaH2ToywRSqmCXR-jXZUhDN2C7rEpzCxiikva54kIiVZhc6zC1-KN99LLywHNgvHlZSdrnL6cyGkWy8WPw6Sb26TpwfxA97pJ2nCa0s3njSW-3deIjcAaUoYg7cG84jBZHn1FUaaoWZcIQvSzEQOnAzU5ThqsgrEUhMpwDjzrVGY5QGu_Z0cE0qdYfk3bVYieQHSIHHv5VsE0EEqOQpzfY7_qEWyYJkCypwbHVwD_feDKNY7tx-99F78AFTjxjgzB3YLtZt-YunEs_N0f1egRn5DIcwdnZ2_l-PLJ2-BP8YzUw
linkProvider	Wiley-Blackwell
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpZ1fb5RAEMAnTTXqi___oFVXo-Z8wMAu1wXjy8W2tpFeTKxt3za7sNhGDpo70Fc_gA9-Rj-JMwtHbKzGxDcCw7LAzO5vFmYG4InNCplIE_s6S9Z9CtX0TSZyPzCJCbIgLrrwsf1UTqfx4WHybgVeLWNhuvwQw4IbWYYbr8nAaUH6FyvXZfkiRJVE3-dchKBBhRsOdqbDOCz7FRYkCD9Cu-7zCtF_PMOpp2ej3xBzyB96Gl3d3LN15f96fRUu98zJJp2SXIMVW12HC7v9V_Ub8A0HjHbGKOdxjRZfMRfgYhesqRkt0f74-p0z1ERUni7QkekqZyUOE4ymRbcHz9KL5mimX7IN3WhGYSsM4ZKV9Ks5OxnqhGFjNHPmjErzzhv2_gtFBh-xN5MRf55uTm_Ch63Nvdfbfl-lwc_Ggoe-SMYB10Kj48ELa01uQ5FLkSMJcBvkoRnbRNgioURoYZSjOxNJqaN1nqBrlyMQ3YLVqq7sHWBISybkmguJYGELY-LMEZAJ0dEqosCD0fJtqaxPYU6VNEq1dGXw6Sr3dD14PIiedHk7zhJaW75y1ZvuQoXInBElKeIePBoOo9HRlxRd2bpFmThGRwtJUHpwu1OV4SrIa0mMGOfBs053hiOUyXvjeH-i6vlH1c5a7ATiQ-LB078KtkogNAp5doP9rk-4ZVWEcEkNjpwK_vnG1SRN3cbdfxd9CBe393ZTle5M396DS5zwxsVkrsFqM2_tfTiffW6OF_MHzgx_AjFUNsY
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpZ3NbtQwEIBH1RZVXMo_BAoYBGg5BCV2to4RlxXbBURYVUCr3iw7dtqKbLLaTeDKA3DgGXkSxkk2oqIgJG5RMnGcZMb-xsnMADyyacYF17GvUrHru1BNX6fM-IEWOkiDOGvDxw4TPpvFR0difwNerGNh2vwQ_YKbs4xmvHYGbhcm-8XKVZ4_C1El0ffZjFwRmQFsTt5PD5J-JObdGgsyhB-hZXeZhdyfPP3JZ-ej3yCzzyB6Fl6b2Wd66f_6fRm2O-ok41ZNrsCGLa7C1rvuu_o1-IZDRj0nLutxiTZfkCbExa5IVRK3SPvj63dKUBdRfdpQR6IKQ3IcKIibGJs9eJZaVSdz9ZxMVKWIC1whiJckdz-bk0VfKQwbc3OnIa4477IiH7642OAT8mo8pE-Tvdl1OJjufXz52u_qNPjpiNHQZ2IUUMUUuh40s1YbGzLDmUEWoDYwoR5ZwWwmXCq0MDLo0EScq2iXCnTuDCLRDRgUZWFvAUFe0iFVlHFEC5tpHacNA-kQXa0sCjwYrt-WTLsk5q6WRi7Xzgw-Xdk8XQ8e9qKLNnPHeUI761cuO-NdyRCpM3JpiqgHD_rDaHbuW4oqbFmjTByjq4UsyD242apKfxUkNhEjyHnwpNWd_ojL5T05PRzLcnks63mNnUCAEB48_qtgLRliI-PnN9jt-oRbVkaIl67BYaOCf75xOU6SZuP2v4veh639yVQmb2Zv78BF6vimCcrcgUG1rO1duJB-rk5Xy3udHf4ETDc3bw
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Serum+periostin+relates+to+type-2+inflammation+and+lung+function+in+asthma%3A+Data+from+the+large+population-based+cohort+Swedish+GA%282%29LEN&rft.jtitle=Allergy+%28Copenhagen%29&rft.au=James%2C+A&rft.au=Janson%2C+C&rft.au=Malinovschi%2C+A&rft.au=Holweg%2C+C&rft.date=2017-11-01&rft.eissn=1398-9995&rft.volume=72&rft.issue=11&rft.spage=1753&rft_id=info:doi/10.1111%2Fall.13181&rft_id=info%3Apmid%2F28398635&rft.externalDocID=28398635
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0105-4538&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0105-4538&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0105-4538&client=summon