Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosis

[Display omitted] •MycoTRAP-DB, a database of mutations and their impact on normal functionality of protein in M.tb genes.•Several secondary mutations were identified with significant impact on protein structure and function.•Comprehensive information gives insight for screening of suspected hotspot...

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Vydané v:	Computational and structural biotechnology journal Ročník 19; s. 2423 - 2446
Hlavní autori:	Singh, Pooja, Jamal, Salma, Ahmed, Faraz, Saqib, Najumu, Mehra, Seema, Ali, Waseem, Roy, Deodutta, Ehtesham, Nasreen Z., Hasnain, Seyed E.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Elsevier B.V 01.01.2021 Research Network of Computational and Structural Biotechnology Elsevier
Predmet:	amino acid sequences bioinformatics biotechnology diagnostic techniques drug resistance drugs genes Genome sequencing MDR mutation Mycobacterium tuberculosis MycoTRAP-DB pathogenicity prediction prioritization Secondary mutations SNPs Tuberculosis SNPs Secondary mutations MDR Tuberculosis Genome sequencing MycoTRAP-DB
ISSN:	2001-0370, 2001-0370
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