Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosis

[Display omitted] •MycoTRAP-DB, a database of mutations and their impact on normal functionality of protein in M.tb genes.•Several secondary mutations were identified with significant impact on protein structure and function.•Comprehensive information gives insight for screening of suspected hotspot...

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Veröffentlicht in:	Computational and structural biotechnology journal Jg. 19; S. 2423 - 2446
Hauptverfasser:	Singh, Pooja, Jamal, Salma, Ahmed, Faraz, Saqib, Najumu, Mehra, Seema, Ali, Waseem, Roy, Deodutta, Ehtesham, Nasreen Z., Hasnain, Seyed E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Elsevier B.V 01.01.2021 Research Network of Computational and Structural Biotechnology Elsevier
Schlagworte:	amino acid sequences bioinformatics biotechnology diagnostic techniques drug resistance drugs genes Genome sequencing MDR mutation Mycobacterium tuberculosis MycoTRAP-DB pathogenicity prediction prioritization Secondary mutations SNPs Tuberculosis SNPs Secondary mutations MDR Tuberculosis Genome sequencing MycoTRAP-DB
ISSN:	2001-0370, 2001-0370
Online-Zugang:	Volltext
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