Computational approaches to fMRI analysis

A revolution is underway in cognitive neuroscience, where tools and techniques from computer science and the tech industry are helping to extract more meaningful cognitive signals from noisy and increasingly large fMRI datasets. In this paper, the authors review the cutting edge of such computationa...

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Veröffentlicht in:Nature neuroscience Jg. 20; H. 3; S. 304 - 313
Hauptverfasser: Cohen, Jonathan D, Daw, Nathaniel, Engelhardt, Barbara, Hasson, Uri, Li, Kai, Niv, Yael, Norman, Kenneth A, Pillow, Jonathan, Ramadge, Peter J, Turk-Browne, Nicholas B, Willke, Theodore L
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Nature Publishing Group US 01.03.2017
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ISSN:1097-6256, 1546-1726, 1546-1726
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Abstract A revolution is underway in cognitive neuroscience, where tools and techniques from computer science and the tech industry are helping to extract more meaningful cognitive signals from noisy and increasingly large fMRI datasets. In this paper, the authors review the cutting edge of such computational analyses and discuss future opportunities and challenges. Analysis methods in cognitive neuroscience have not always matched the richness of fMRI data. Early methods focused on estimating neural activity within individual voxels or regions, averaged over trials or blocks and modeled separately in each participant. This approach mostly neglected the distributed nature of neural representations over voxels, the continuous dynamics of neural activity during tasks, the statistical benefits of performing joint inference over multiple participants and the value of using predictive models to constrain analysis. Several recent exploratory and theory-driven methods have begun to pursue these opportunities. These methods highlight the importance of computational techniques in fMRI analysis, especially machine learning, algorithmic optimization and parallel computing. Adoption of these techniques is enabling a new generation of experiments and analyses that could transform our understanding of some of the most complex—and distinctly human—signals in the brain: acts of cognition such as thoughts, intentions and memories.
AbstractList A revolution is underway in cognitive neuroscience, where tools and techniques from computer science and the tech industry are helping to extract more meaningful cognitive signals from noisy and increasingly large fMRI datasets. In this paper, the authors review the cutting edge of such computational analyses and discuss future opportunities and challenges. Analysis methods in cognitive neuroscience have not always matched the richness of fMRI data. Early methods focused on estimating neural activity within individual voxels or regions, averaged over trials or blocks and modeled separately in each participant. This approach mostly neglected the distributed nature of neural representations over voxels, the continuous dynamics of neural activity during tasks, the statistical benefits of performing joint inference over multiple participants and the value of using predictive models to constrain analysis. Several recent exploratory and theory-driven methods have begun to pursue these opportunities. These methods highlight the importance of computational techniques in fMRI analysis, especially machine learning, algorithmic optimization and parallel computing. Adoption of these techniques is enabling a new generation of experiments and analyses that could transform our understanding of some of the most complex—and distinctly human—signals in the brain: acts of cognition such as thoughts, intentions and memories.
Analysis methods in cognitive neuroscience have not always matched the richness of fMRI data. Early methods focused on estimating neural activity within individual voxels or regions, averaged over trials or blocks and modeled separately in each participant. This approach mostly neglected the distributed nature of neural representations over voxels, the continuous dynamics of neural activity during tasks, the statistical benefits of performing joint inference over multiple participants and the value of using predictive models to constrain analysis. Several recent exploratory and theory-driven methods have begun to pursue these opportunities. These methods highlight the importance of computational techniques in fMRI analysis, especially machine learning, algorithmic optimization and parallel computing. Adoption of these techniques is enabling a new generation of experiments and analyses that could transform our understanding of some of the most complex--and distinctly human--signals in the brain: acts of cognition such as thoughts, intentions and memories.
Analysis methods in cognitive neuroscience have not always matched the richness of fMRI data. Early methods focused on estimating neural activity within individual voxels or regions, averaged over trials or blocks and modeled separately in each participant. This approach mostly neglected the distributed nature of neural representations over voxels, the continuous dynamics of neural activity during tasks, the statistical benefits of performing joint inference over multiple participants and the value of using predictive models to constrain analysis. Several recent exploratory and theory-driven methods have begun to pursue these opportunities. These methods highlight the importance of computational techniques in fMRI analysis, especially machine learning, algorithmic optimization and parallel computing. Adoption of these techniques is enabling a new generation of experiments and analyses that could transform our understanding of some of the most complex-and distinctly human-signals in the brain: acts of cognition such as thoughts, intentions and memories.Analysis methods in cognitive neuroscience have not always matched the richness of fMRI data. Early methods focused on estimating neural activity within individual voxels or regions, averaged over trials or blocks and modeled separately in each participant. This approach mostly neglected the distributed nature of neural representations over voxels, the continuous dynamics of neural activity during tasks, the statistical benefits of performing joint inference over multiple participants and the value of using predictive models to constrain analysis. Several recent exploratory and theory-driven methods have begun to pursue these opportunities. These methods highlight the importance of computational techniques in fMRI analysis, especially machine learning, algorithmic optimization and parallel computing. Adoption of these techniques is enabling a new generation of experiments and analyses that could transform our understanding of some of the most complex-and distinctly human-signals in the brain: acts of cognition such as thoughts, intentions and memories.
Audience Academic
Author Li, Kai
Norman, Kenneth A
Pillow, Jonathan
Cohen, Jonathan D
Niv, Yael
Ramadge, Peter J
Turk-Browne, Nicholas B
Willke, Theodore L
Daw, Nathaniel
Engelhardt, Barbara
Hasson, Uri
AuthorAffiliation 1 Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA
2 Department of Psychology, Princeton University, Princeton, New Jersey, USA
3 Department of Computer Science, Princeton University, Princeton, New Jersey, USA
4 Department of Electrical Engineering, Princeton University, Princeton, New Jersey, USA
5 Intel Labs, Intel Corporation, Santa Clara, California, USA
AuthorAffiliation_xml – name: 5 Intel Labs, Intel Corporation, Santa Clara, California, USA
– name: 1 Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA
– name: 4 Department of Electrical Engineering, Princeton University, Princeton, New Jersey, USA
– name: 3 Department of Computer Science, Princeton University, Princeton, New Jersey, USA
– name: 2 Department of Psychology, Princeton University, Princeton, New Jersey, USA
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  surname: Cohen
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– sequence: 11
  givenname: Theodore L
  surname: Willke
  fullname: Willke, Theodore L
  organization: Intel Labs, Intel Corporation, Santa Clara, California, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28230848$$D View this record in MEDLINE/PubMed
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Snippet A revolution is underway in cognitive neuroscience, where tools and techniques from computer science and the tech industry are helping to extract more...
Analysis methods in cognitive neuroscience have not always matched the richness of fMRI data. Early methods focused on estimating neural activity within...
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SubjectTerms 59/36
631/378/2649
631/477
Analysis
Animal Genetics and Genomics
Behavioral Sciences
Biological Techniques
Biomedicine
Brain - physiology
Brain Mapping - methods
Cognition
Cognition - physiology
Computer engineering
Computer science
Control theory
Hemodynamics
Humans
Learning - physiology
Machine learning
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medical imaging
Methods
Models, Neurological
Neurobiology
Neuroimaging
Neurosciences
perspective
Software
Title Computational approaches to fMRI analysis
URI https://link.springer.com/article/10.1038/nn.4499
https://www.ncbi.nlm.nih.gov/pubmed/28230848
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Volume 20
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