Computational approaches to fMRI analysis
A revolution is underway in cognitive neuroscience, where tools and techniques from computer science and the tech industry are helping to extract more meaningful cognitive signals from noisy and increasingly large fMRI datasets. In this paper, the authors review the cutting edge of such computationa...
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| Veröffentlicht in: | Nature neuroscience Jg. 20; H. 3; S. 304 - 313 |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
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Nature Publishing Group US
01.03.2017
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| ISSN: | 1097-6256, 1546-1726, 1546-1726 |
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| Abstract | A revolution is underway in cognitive neuroscience, where tools and techniques from computer science and the tech industry are helping to extract more meaningful cognitive signals from noisy and increasingly large fMRI datasets. In this paper, the authors review the cutting edge of such computational analyses and discuss future opportunities and challenges.
Analysis methods in cognitive neuroscience have not always matched the richness of fMRI data. Early methods focused on estimating neural activity within individual voxels or regions, averaged over trials or blocks and modeled separately in each participant. This approach mostly neglected the distributed nature of neural representations over voxels, the continuous dynamics of neural activity during tasks, the statistical benefits of performing joint inference over multiple participants and the value of using predictive models to constrain analysis. Several recent exploratory and theory-driven methods have begun to pursue these opportunities. These methods highlight the importance of computational techniques in fMRI analysis, especially machine learning, algorithmic optimization and parallel computing. Adoption of these techniques is enabling a new generation of experiments and analyses that could transform our understanding of some of the most complex—and distinctly human—signals in the brain: acts of cognition such as thoughts, intentions and memories. |
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| AbstractList | A revolution is underway in cognitive neuroscience, where tools and techniques from computer science and the tech industry are helping to extract more meaningful cognitive signals from noisy and increasingly large fMRI datasets. In this paper, the authors review the cutting edge of such computational analyses and discuss future opportunities and challenges.
Analysis methods in cognitive neuroscience have not always matched the richness of fMRI data. Early methods focused on estimating neural activity within individual voxels or regions, averaged over trials or blocks and modeled separately in each participant. This approach mostly neglected the distributed nature of neural representations over voxels, the continuous dynamics of neural activity during tasks, the statistical benefits of performing joint inference over multiple participants and the value of using predictive models to constrain analysis. Several recent exploratory and theory-driven methods have begun to pursue these opportunities. These methods highlight the importance of computational techniques in fMRI analysis, especially machine learning, algorithmic optimization and parallel computing. Adoption of these techniques is enabling a new generation of experiments and analyses that could transform our understanding of some of the most complex—and distinctly human—signals in the brain: acts of cognition such as thoughts, intentions and memories. Analysis methods in cognitive neuroscience have not always matched the richness of fMRI data. Early methods focused on estimating neural activity within individual voxels or regions, averaged over trials or blocks and modeled separately in each participant. This approach mostly neglected the distributed nature of neural representations over voxels, the continuous dynamics of neural activity during tasks, the statistical benefits of performing joint inference over multiple participants and the value of using predictive models to constrain analysis. Several recent exploratory and theory-driven methods have begun to pursue these opportunities. These methods highlight the importance of computational techniques in fMRI analysis, especially machine learning, algorithmic optimization and parallel computing. Adoption of these techniques is enabling a new generation of experiments and analyses that could transform our understanding of some of the most complex--and distinctly human--signals in the brain: acts of cognition such as thoughts, intentions and memories. Analysis methods in cognitive neuroscience have not always matched the richness of fMRI data. Early methods focused on estimating neural activity within individual voxels or regions, averaged over trials or blocks and modeled separately in each participant. This approach mostly neglected the distributed nature of neural representations over voxels, the continuous dynamics of neural activity during tasks, the statistical benefits of performing joint inference over multiple participants and the value of using predictive models to constrain analysis. Several recent exploratory and theory-driven methods have begun to pursue these opportunities. These methods highlight the importance of computational techniques in fMRI analysis, especially machine learning, algorithmic optimization and parallel computing. Adoption of these techniques is enabling a new generation of experiments and analyses that could transform our understanding of some of the most complex-and distinctly human-signals in the brain: acts of cognition such as thoughts, intentions and memories.Analysis methods in cognitive neuroscience have not always matched the richness of fMRI data. Early methods focused on estimating neural activity within individual voxels or regions, averaged over trials or blocks and modeled separately in each participant. This approach mostly neglected the distributed nature of neural representations over voxels, the continuous dynamics of neural activity during tasks, the statistical benefits of performing joint inference over multiple participants and the value of using predictive models to constrain analysis. Several recent exploratory and theory-driven methods have begun to pursue these opportunities. These methods highlight the importance of computational techniques in fMRI analysis, especially machine learning, algorithmic optimization and parallel computing. Adoption of these techniques is enabling a new generation of experiments and analyses that could transform our understanding of some of the most complex-and distinctly human-signals in the brain: acts of cognition such as thoughts, intentions and memories. |
| Audience | Academic |
| Author | Li, Kai Norman, Kenneth A Pillow, Jonathan Cohen, Jonathan D Niv, Yael Ramadge, Peter J Turk-Browne, Nicholas B Willke, Theodore L Daw, Nathaniel Engelhardt, Barbara Hasson, Uri |
| AuthorAffiliation | 1 Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA 2 Department of Psychology, Princeton University, Princeton, New Jersey, USA 3 Department of Computer Science, Princeton University, Princeton, New Jersey, USA 4 Department of Electrical Engineering, Princeton University, Princeton, New Jersey, USA 5 Intel Labs, Intel Corporation, Santa Clara, California, USA |
| AuthorAffiliation_xml | – name: 5 Intel Labs, Intel Corporation, Santa Clara, California, USA – name: 1 Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA – name: 4 Department of Electrical Engineering, Princeton University, Princeton, New Jersey, USA – name: 3 Department of Computer Science, Princeton University, Princeton, New Jersey, USA – name: 2 Department of Psychology, Princeton University, Princeton, New Jersey, USA |
| Author_xml | – sequence: 1 givenname: Jonathan D surname: Cohen fullname: Cohen, Jonathan D organization: Princeton Neuroscience Institute, Princeton University, Department of Psychology, Princeton University – sequence: 2 givenname: Nathaniel orcidid: 0000-0001-5029-1430 surname: Daw fullname: Daw, Nathaniel organization: Princeton Neuroscience Institute, Princeton University, Department of Psychology, Princeton University – sequence: 3 givenname: Barbara surname: Engelhardt fullname: Engelhardt, Barbara organization: Department of Computer Science, Princeton University – sequence: 4 givenname: Uri surname: Hasson fullname: Hasson, Uri organization: Princeton Neuroscience Institute, Princeton University, Department of Psychology, Princeton University – sequence: 5 givenname: Kai surname: Li fullname: Li, Kai organization: Department of Computer Science, Princeton University – sequence: 6 givenname: Yael orcidid: 0000-0002-0259-8371 surname: Niv fullname: Niv, Yael organization: Princeton Neuroscience Institute, Princeton University, Department of Psychology, Princeton University – sequence: 7 givenname: Kenneth A surname: Norman fullname: Norman, Kenneth A organization: Princeton Neuroscience Institute, Princeton University, Department of Psychology, Princeton University – sequence: 8 givenname: Jonathan surname: Pillow fullname: Pillow, Jonathan organization: Princeton Neuroscience Institute, Princeton University, Department of Psychology, Princeton University – sequence: 9 givenname: Peter J surname: Ramadge fullname: Ramadge, Peter J organization: Department of Electrical Engineering, Princeton University – sequence: 10 givenname: Nicholas B surname: Turk-Browne fullname: Turk-Browne, Nicholas B email: ntb@princeton.edu organization: Princeton Neuroscience Institute, Princeton University, Department of Psychology, Princeton University – sequence: 11 givenname: Theodore L surname: Willke fullname: Willke, Theodore L organization: Intel Labs, Intel Corporation, Santa Clara, California, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28230848$$D View this record in MEDLINE/PubMed |
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| Snippet | A revolution is underway in cognitive neuroscience, where tools and techniques from computer science and the tech industry are helping to extract more... Analysis methods in cognitive neuroscience have not always matched the richness of fMRI data. Early methods focused on estimating neural activity within... |
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| SubjectTerms | 59/36 631/378/2649 631/477 Analysis Animal Genetics and Genomics Behavioral Sciences Biological Techniques Biomedicine Brain - physiology Brain Mapping - methods Cognition Cognition - physiology Computer engineering Computer science Control theory Hemodynamics Humans Learning - physiology Machine learning Magnetic resonance imaging Magnetic Resonance Imaging - methods Medical imaging Methods Models, Neurological Neurobiology Neuroimaging Neurosciences perspective Software |
| Title | Computational approaches to fMRI analysis |
| URI | https://link.springer.com/article/10.1038/nn.4499 https://www.ncbi.nlm.nih.gov/pubmed/28230848 https://www.proquest.com/docview/1891851197 https://www.proquest.com/docview/1871549785 https://www.proquest.com/docview/1897372275 https://pubmed.ncbi.nlm.nih.gov/PMC5457304 |
| Volume | 20 |
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