Neural sensitivity to social rejection is associated with inflammatory responses to social stress
Although stress-induced increases in inflammation have been implicated in several major disorders, including cardiovascular disease and depression, the neurocognitive pathways that underlie inflammatory responses to stress remain largely unknown. To examine these processes, we recruited 124 healthy...
Saved in:
| Published in: | Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 33; p. 14817 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
17.08.2010
|
| Subjects: | |
| ISSN: | 1091-6490, 1091-6490 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Although stress-induced increases in inflammation have been implicated in several major disorders, including cardiovascular disease and depression, the neurocognitive pathways that underlie inflammatory responses to stress remain largely unknown. To examine these processes, we recruited 124 healthy young adult participants to complete a laboratory-based social stressor while markers of inflammatory activity were obtained from oral fluids. A subset of participants (n = 31) later completed an fMRI session in which their neural responses to social rejection were assessed. As predicted, exposure to the laboratory-based social stressor was associated with significant increases in two markers of inflammatory activity, namely a soluble receptor for tumor necrosis factor-alpha (sTNFalphaRII) and interleukin-6 (IL-6). In the neuroimaging subsample, greater increases in sTNFalphaRII (but not IL-6) were associated with greater activity in the dorsal anterior cingulate cortex and anterior insula, brain regions that have previously been associated with processing rejection-related distress and negative affect. These data thus elucidate a neurocognitive pathway that may be involved in potentiated inflammatory responses to acute social stress. As such, they have implications for understanding how social stressors may promote susceptibility to diseases with an inflammatory component. |
|---|---|
| AbstractList | Although stress-induced increases in inflammation have been implicated in several major disorders, including cardiovascular disease and depression, the neurocognitive pathways that underlie inflammatory responses to stress remain largely unknown. To examine these processes, we recruited 124 healthy young adult participants to complete a laboratory-based social stressor while markers of inflammatory activity were obtained from oral fluids. A subset of participants (n = 31) later completed an fMRI session in which their neural responses to social rejection were assessed. As predicted, exposure to the laboratory-based social stressor was associated with significant increases in two markers of inflammatory activity, namely a soluble receptor for tumor necrosis factor-alpha (sTNFalphaRII) and interleukin-6 (IL-6). In the neuroimaging subsample, greater increases in sTNFalphaRII (but not IL-6) were associated with greater activity in the dorsal anterior cingulate cortex and anterior insula, brain regions that have previously been associated with processing rejection-related distress and negative affect. These data thus elucidate a neurocognitive pathway that may be involved in potentiated inflammatory responses to acute social stress. As such, they have implications for understanding how social stressors may promote susceptibility to diseases with an inflammatory component. Although stress-induced increases in inflammation have been implicated in several major disorders, including cardiovascular disease and depression, the neurocognitive pathways that underlie inflammatory responses to stress remain largely unknown. To examine these processes, we recruited 124 healthy young adult participants to complete a laboratory-based social stressor while markers of inflammatory activity were obtained from oral fluids. A subset of participants (n = 31) later completed an fMRI session in which their neural responses to social rejection were assessed. As predicted, exposure to the laboratory-based social stressor was associated with significant increases in two markers of inflammatory activity, namely a soluble receptor for tumor necrosis factor-alpha (sTNFalphaRII) and interleukin-6 (IL-6). In the neuroimaging subsample, greater increases in sTNFalphaRII (but not IL-6) were associated with greater activity in the dorsal anterior cingulate cortex and anterior insula, brain regions that have previously been associated with processing rejection-related distress and negative affect. These data thus elucidate a neurocognitive pathway that may be involved in potentiated inflammatory responses to acute social stress. As such, they have implications for understanding how social stressors may promote susceptibility to diseases with an inflammatory component.Although stress-induced increases in inflammation have been implicated in several major disorders, including cardiovascular disease and depression, the neurocognitive pathways that underlie inflammatory responses to stress remain largely unknown. To examine these processes, we recruited 124 healthy young adult participants to complete a laboratory-based social stressor while markers of inflammatory activity were obtained from oral fluids. A subset of participants (n = 31) later completed an fMRI session in which their neural responses to social rejection were assessed. As predicted, exposure to the laboratory-based social stressor was associated with significant increases in two markers of inflammatory activity, namely a soluble receptor for tumor necrosis factor-alpha (sTNFalphaRII) and interleukin-6 (IL-6). In the neuroimaging subsample, greater increases in sTNFalphaRII (but not IL-6) were associated with greater activity in the dorsal anterior cingulate cortex and anterior insula, brain regions that have previously been associated with processing rejection-related distress and negative affect. These data thus elucidate a neurocognitive pathway that may be involved in potentiated inflammatory responses to acute social stress. As such, they have implications for understanding how social stressors may promote susceptibility to diseases with an inflammatory component. |
| Author | Eisenberger, Naomi I Slavich, George M Way, Baldwin M Taylor, Shelley E |
| Author_xml | – sequence: 1 givenname: George M surname: Slavich fullname: Slavich, George M organization: Department of Psychology, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA 90095, USA – sequence: 2 givenname: Baldwin M surname: Way fullname: Way, Baldwin M – sequence: 3 givenname: Naomi I surname: Eisenberger fullname: Eisenberger, Naomi I – sequence: 4 givenname: Shelley E surname: Taylor fullname: Taylor, Shelley E |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20679216$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkEtLxDAQgIOsuA89e5PePFXzaNL2KIsvWPSi55KmU8zSJrWTKv33Bl1hT_Px8c0cZk0Wzjsg5JLRG0ZzcTs4jZFoyVQWxQlZscipykq6OOIlWSPuaexkQc_IklOVl5ypFdEvMI26SxAc2mC_bJiT4BP0xkY7wh5MsN4lFhONvzZAk3zb8JFY13a673Xw4xxLHLxDwKNtDNHiOTltdYdwcZgb8v5w_7Z9Snevj8_bu11qpGAhhZqzgkkhGJe0Bl4L2khgDFpOZVvrvDWqyRujC6ZYIw0racsFzTMuY1fWfEOu_-4Oo_-cAEPVWzTQddqBn7DKs6JUnGYilleHcqp7aKphtL0e5-r_K_wHSbZoNg |
| CitedBy_id | crossref_primary_10_1002_smi_70039 crossref_primary_10_1016_j_bbi_2018_02_001 crossref_primary_10_1016_j_jpsychires_2011_03_004 crossref_primary_10_1080_03004430_2020_1845667 crossref_primary_10_1016_j_biopsych_2025_04_018 crossref_primary_10_1016_j_psyneuen_2018_08_035 crossref_primary_10_1017_S0954579421000572 crossref_primary_10_3389_fpsyg_2024_1411697 crossref_primary_10_3390_encyclopedia4020066 crossref_primary_10_1093_scan_nss095 crossref_primary_10_1093_scan_nsv001 crossref_primary_10_1177_14747049211016009 crossref_primary_10_1177_1745691616689091 crossref_primary_10_3109_02770903_2011_563807 crossref_primary_10_1016_j_pnpbp_2017_04_021 crossref_primary_10_5498_wjp_v11_i9_553 crossref_primary_10_1002_da_22987 crossref_primary_10_1002_dev_21329 crossref_primary_10_1016_j_copsyc_2019_06_004 crossref_primary_10_1016_j_biopsycho_2015_07_011 crossref_primary_10_1038_s41467_020_15655_5 crossref_primary_10_1007_s11926_017_0686_0 crossref_primary_10_1111_j_1751_9004_2012_00467_x crossref_primary_10_3389_fnins_2017_00490 crossref_primary_10_1016_j_bbi_2019_04_014 crossref_primary_10_1097_QAI_0000000000002596 crossref_primary_10_1016_j_neubiorev_2023_105307 crossref_primary_10_1176_appi_ajp_20250289 crossref_primary_10_3389_fnbeh_2021_802569 crossref_primary_10_1038_mp_2013_20 crossref_primary_10_3389_fnbeh_2018_00240 crossref_primary_10_1016_j_bbi_2014_03_020 crossref_primary_10_1017_S0954579412000041 crossref_primary_10_1016_j_bbi_2024_03_002 crossref_primary_10_1016_j_bbi_2017_01_013 crossref_primary_10_1080_17437199_2023_2171900 crossref_primary_10_1016_j_bbi_2016_10_019 crossref_primary_10_1016_j_copsyc_2016_05_005 crossref_primary_10_1016_j_jpsychires_2023_01_044 crossref_primary_10_3389_fpsyg_2022_926181 crossref_primary_10_1016_j_biopsych_2013_10_012 crossref_primary_10_1007_s11481_012_9422_8 crossref_primary_10_1093_emph_eow003 crossref_primary_10_1111_adb_13287 crossref_primary_10_1016_j_pharmthera_2011_01_014 crossref_primary_10_1002_ejsp_2344 crossref_primary_10_12688_f1000research_74504_4 crossref_primary_10_1007_s40653_022_00463_4 crossref_primary_10_12688_f1000research_74504_5 crossref_primary_10_1186_s13075_015_0783_2 crossref_primary_10_1146_annurev_clinpsy_032816_045159 crossref_primary_10_1093_scan_nsad015 crossref_primary_10_4155_fmc_12_156 crossref_primary_10_3390_brainsci11091226 crossref_primary_10_3390_ijms21155212 crossref_primary_10_1016_j_brainres_2023_148734 crossref_primary_10_1016_j_neuroimage_2020_117434 crossref_primary_10_1007_s12525_021_00501_3 crossref_primary_10_1017_S0954579423000974 crossref_primary_10_3389_fpsyt_2025_1635817 crossref_primary_10_1016_j_bbr_2017_04_020 crossref_primary_10_1016_j_bbih_2024_100758 crossref_primary_10_3389_fnagi_2019_00161 crossref_primary_10_1016_j_jrp_2016_07_008 crossref_primary_10_1016_j_psyneuen_2018_09_041 crossref_primary_10_1016_j_socscimed_2018_10_008 crossref_primary_10_1080_15298868_2011_625647 crossref_primary_10_1097_PSY_0000000000000685 crossref_primary_10_1016_j_cognition_2016_08_006 crossref_primary_10_1016_j_eujim_2024_102388 crossref_primary_10_1183_09031936_00205113 crossref_primary_10_3390_ijms21186546 crossref_primary_10_1089_act_2014_20507 crossref_primary_10_1111_nyas_14880 crossref_primary_10_1016_j_conb_2013_01_006 crossref_primary_10_1136_bjsports_2017_098983 crossref_primary_10_1007_s11682_019_00121_8 crossref_primary_10_1038_s41398_024_03008_5 crossref_primary_10_1093_scan_nsu110 crossref_primary_10_1016_j_neubiorev_2017_10_001 crossref_primary_10_1016_j_bbi_2019_09_023 crossref_primary_10_1038_s41598_024_56145_8 crossref_primary_10_1016_j_ijpsycho_2017_11_010 crossref_primary_10_1038_tp_2013_119 crossref_primary_10_1016_j_psyneuen_2021_105411 crossref_primary_10_1017_S0033291725101384 crossref_primary_10_1080_00049530_2021_1883409 crossref_primary_10_1371_journal_pone_0275421 crossref_primary_10_1073_pnas_1616130114 crossref_primary_10_1038_nrn3776 crossref_primary_10_1093_milmed_usac095 crossref_primary_10_1371_journal_pone_0090651 crossref_primary_10_1016_j_encep_2018_09_005 crossref_primary_10_3389_fpsyg_2024_1441493 crossref_primary_10_1016_j_bbi_2021_12_003 crossref_primary_10_1097_PSY_0000000000000300 crossref_primary_10_1016_j_biopsych_2013_11_011 crossref_primary_10_1111_nyas_14660 crossref_primary_10_1177_2167702612455743 crossref_primary_10_1038_s41598_025_07783_z crossref_primary_10_1016_j_psyneuen_2014_07_009 crossref_primary_10_1177_1044389418802515 crossref_primary_10_1177_1948550616662130 crossref_primary_10_1177_1948550613494226 crossref_primary_10_1016_j_neubiorev_2018_07_013 crossref_primary_10_1016_j_neuroscience_2018_03_034 crossref_primary_10_1016_j_yfrne_2018_03_001 crossref_primary_10_1016_j_bbih_2025_100984 crossref_primary_10_1097_HRP_0000000000000199 crossref_primary_10_1016_j_neubiorev_2021_02_010 crossref_primary_10_1038_nri_2015_5 crossref_primary_10_1002_da_22084 crossref_primary_10_3389_fpsyt_2019_00458 crossref_primary_10_1097_PSY_0000000000000311 crossref_primary_10_1038_bmt_2014_179 crossref_primary_10_3389_fpsyg_2016_01570 crossref_primary_10_1016_j_bbi_2015_01_003 crossref_primary_10_1038_nn_4426 crossref_primary_10_1371_journal_pone_0070808 crossref_primary_10_1097_PSY_0b013e31828b5366 crossref_primary_10_1521_prev_2012_99_4_515 crossref_primary_10_1080_17470919_2013_833984 crossref_primary_10_1016_j_bbi_2017_09_011 crossref_primary_10_1016_j_jpsychores_2018_01_005 crossref_primary_10_1097_PSY_0000000000000309 crossref_primary_10_3390_brainsci15020121 crossref_primary_10_1016_j_burns_2015_08_033 crossref_primary_10_1177_1088868314544222 crossref_primary_10_3389_fnins_2019_00384 crossref_primary_10_3390_ph12030126 crossref_primary_10_1177_17456916221094856 crossref_primary_10_1016_j_neubiorev_2013_11_005 crossref_primary_10_1177_0956797615595962 crossref_primary_10_1111_jcpp_12804 crossref_primary_10_1016_j_bbih_2025_101051 crossref_primary_10_1016_j_bbi_2017_06_015 crossref_primary_10_1038_nn_3086 crossref_primary_10_1016_j_jad_2019_06_071 crossref_primary_10_1080_15265161_2020_1863508 crossref_primary_10_1002_lim2_75 crossref_primary_10_1007_s10508_015_0480_x crossref_primary_10_1016_j_jad_2025_01_094 crossref_primary_10_1016_j_jad_2014_07_032 crossref_primary_10_3758_s13415_020_00782_9 crossref_primary_10_3389_fpsyg_2019_02200 crossref_primary_10_1177_1948550612443715 crossref_primary_10_1016_j_jad_2023_10_113 crossref_primary_10_1007_s11724_017_0505_4 crossref_primary_10_1016_j_physbeh_2020_113140 crossref_primary_10_1016_j_jesp_2014_10_002 crossref_primary_10_1177_0261927X231151408 crossref_primary_10_1016_j_psychres_2019_02_023 crossref_primary_10_1111_ejn_15481 crossref_primary_10_1038_s41398_022_01835_y crossref_primary_10_1038_mp_2012_2 crossref_primary_10_7717_peerj_4305 crossref_primary_10_1016_j_schres_2020_11_056 crossref_primary_10_1038_npp_2016_141 crossref_primary_10_1111_sltb_12993 crossref_primary_10_1038_npp_2011_205 crossref_primary_10_1016_j_biopsycho_2013_01_018 crossref_primary_10_1177_20552076211037227 crossref_primary_10_1038_s41598_019_41437_1 crossref_primary_10_1007_s12529_013_9368_0 crossref_primary_10_1177_2167702613478594 crossref_primary_10_1002_jnr_24314 crossref_primary_10_4239_wjd_v15_i6_1374 crossref_primary_10_1016_j_jpsychires_2019_09_010 crossref_primary_10_1093_scan_nsab008 crossref_primary_10_1186_s12888_019_2404_0 crossref_primary_10_1016_j_psyneuen_2015_08_020 crossref_primary_10_1080_02699931_2022_2163619 crossref_primary_10_1177_0165025420979369 crossref_primary_10_1177_0098628316662768 crossref_primary_10_1016_j_psyneuen_2021_105241 crossref_primary_10_1016_j_bbih_2022_100564 crossref_primary_10_1002_bdm_1886 crossref_primary_10_1016_j_yhbeh_2015_01_004 crossref_primary_10_1177_2167702617745641 crossref_primary_10_1200_JCO_2011_36_1154 crossref_primary_10_3389_fpsyt_2020_00758 crossref_primary_10_1016_j_bbi_2014_06_201 crossref_primary_10_1177_1745691613497965 crossref_primary_10_1093_scan_nsw021 crossref_primary_10_1111_joss_12536 crossref_primary_10_1016_j_cpr_2018_05_007 crossref_primary_10_1080_10720537_2016_1268080 crossref_primary_10_1016_j_ijpsycho_2018_03_023 crossref_primary_10_1016_j_obmed_2019_100117 crossref_primary_10_1002_dev_21271 crossref_primary_10_3389_fpsyg_2019_03083 crossref_primary_10_1017_S0033291722002239 crossref_primary_10_1080_15374416_2020_1756299 crossref_primary_10_1016_j_jenvp_2022_101951 crossref_primary_10_1016_j_psyneuen_2014_11_010 crossref_primary_10_1002_da_20876 crossref_primary_10_1016_j_neuropsychologia_2022_108374 crossref_primary_10_1097_HRP_0000000000000326 crossref_primary_10_1016_j_bbi_2012_07_015 crossref_primary_10_1111_spc3_12471 crossref_primary_10_1016_j_paid_2021_111179 crossref_primary_10_1097_PSY_0b013e3182688e8b crossref_primary_10_1007_s10648_012_9199_6 crossref_primary_10_3166_dea_2018_0013 crossref_primary_10_1093_abm_kaz015 crossref_primary_10_1016_j_neubiorev_2019_12_011 crossref_primary_10_1038_npp_2016_194 crossref_primary_10_1111_nyas_13708 crossref_primary_10_1111_ajsp_12069 crossref_primary_10_1016_j_psychres_2014_12_053 crossref_primary_10_1016_j_biopsycho_2013_06_006 crossref_primary_10_1007_s00221_017_4949_9 crossref_primary_10_3390_psych4030038 crossref_primary_10_1093_scan_nsaa042 crossref_primary_10_1177_1559827619845335 crossref_primary_10_1016_j_bbi_2013_05_008 crossref_primary_10_3389_fnagi_2021_682308 crossref_primary_10_1016_j_bbi_2011_05_010 crossref_primary_10_1016_j_jpsychires_2022_03_004 crossref_primary_10_1016_j_actpsy_2022_103603 crossref_primary_10_1007_s11055_021_01080_8 crossref_primary_10_1016_j_neubiorev_2012_10_013 crossref_primary_10_1007_s11357_024_01416_5 crossref_primary_10_1016_j_jpsychires_2020_05_013 crossref_primary_10_1016_j_bbih_2022_100495 crossref_primary_10_2217_pmt_15_56 crossref_primary_10_1111_1468_5922_12021 crossref_primary_10_3389_fpsyg_2021_785610 crossref_primary_10_1016_j_neuroscience_2014_06_002 crossref_primary_10_1038_s41591_019_0675_0 crossref_primary_10_1016_j_psyneuen_2020_104671 crossref_primary_10_1371_journal_pone_0123565 crossref_primary_10_1111_soc4_12720 crossref_primary_10_1016_j_bbi_2023_10_033 crossref_primary_10_1016_j_pnpbp_2012_12_013 crossref_primary_10_1017_pen_2025_10003 crossref_primary_10_1038_npp_2014_25 crossref_primary_10_1111_spc3_12335 crossref_primary_10_1080_23808985_2020_1843366 crossref_primary_10_1016_j_paid_2015_06_029 crossref_primary_10_1080_14737175_2019_1620604 crossref_primary_10_1016_j_chb_2024_108283 crossref_primary_10_1016_j_biopsych_2014_09_023 crossref_primary_10_1177_05333164221091946 crossref_primary_10_1016_j_nicl_2021_102851 crossref_primary_10_1038_s41598_017_01053_3 crossref_primary_10_1038_npp_2016_167 crossref_primary_10_1038_nrn3231 crossref_primary_10_1177_1359105316676331 crossref_primary_10_1016_j_psyneuen_2022_105690 crossref_primary_10_1016_j_bbi_2017_02_006 crossref_primary_10_1016_j_biopsych_2011_10_021 crossref_primary_10_1080_00224545_2018_1532388 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1073/pnas.1009164107 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Sciences (General) |
| EISSN | 1091-6490 |
| ExternalDocumentID | 20679216 |
| Genre | Clinical Trial Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIA NIH HHS grantid: AG030309 – fundername: NIMH NIH HHS grantid: R01 MH056880 – fundername: NIMH NIH HHS grantid: T32MH019925 – fundername: NIMH NIH HHS grantid: T32 MH019925 – fundername: NIMH NIH HHS grantid: MH56880 – fundername: NIA NIH HHS grantid: R01 AG030309 |
| GroupedDBID | --- -DZ -~X .55 0R~ 123 29P 2AX 2FS 2WC 4.4 53G 5RE 5VS 85S AACGO AAFWJ AANCE AAYJJ ABBHK ABOCM ABPLY ABPPZ ABTLG ABXSQ ABZEH ACGOD ACHIC ACIWK ACNCT ACPRK ADQXQ ADULT ADXHL AENEX AEUPB AEXZC AFFNX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS AQVQM AS~ BKOMP CGR CS3 CUY CVF D0L DCCCD DIK DU5 E3Z EBS ECM EIF EJD F5P FRP GX1 H13 HH5 HQ3 HTVGU HYE IPSME JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JST KQ8 L7B LU7 MVM N9A NPM N~3 O9- OK1 P-O PNE PQQKQ R.V RHI RNA RNS RPM RXW SA0 SJN TAE TN5 UKR W8F WH7 WOQ WOW X7M XSW Y6R YBH YKV YSK ZCA ~02 ~KM 7X8 |
| ID | FETCH-LOGICAL-c531t-eb21815331250be2b30d5e11ef205fba7fc6d7dca8161d5c190f2307425d5e9b2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 287 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000281287600054&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1091-6490 |
| IngestDate | Fri Sep 05 14:28:55 EDT 2025 Mon Jul 21 06:06:02 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 33 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c531t-eb21815331250be2b30d5e11ef205fba7fc6d7dca8161d5c190f2307425d5e9b2 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/2930449 |
| PMID | 20679216 |
| PQID | 748962043 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_748962043 pubmed_primary_20679216 |
| PublicationCentury | 2000 |
| PublicationDate | 2010-08-17 |
| PublicationDateYYYYMMDD | 2010-08-17 |
| PublicationDate_xml | – month: 08 year: 2010 text: 2010-08-17 day: 17 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Proceedings of the National Academy of Sciences - PNAS |
| PublicationTitleAlternate | Proc Natl Acad Sci U S A |
| PublicationYear | 2010 |
| References | 18282566 - Eur J Pharmacol. 2008 Apr 7;583(2-3):174-85 19196810 - Psychosom Med. 2009 Apr;71(3):329-33 19150053 - Biol Psychiatry. 2009 May 1;65(9):732-41 9600484 - JAMA. 1998 May 13;279(18):1477-82 16557263 - Nat Rev Immunol. 2006 Apr;6(4):318-28 19465135 - Neuroimage. 2009 Sep;47(3):836-51 9826274 - J Comp Neurol. 1998 Nov 30;401(4):480-505 15265539 - Brain Behav Immun. 2004 Sep;18(5):458-67 18611955 - Am J Epidemiol. 2008 Sep 1;168(5):481-91; discussion 492-6 18778779 - Neuroimage. 2009 Jan 1;44(1):213-22 18799429 - Psychosom Med. 2008 Oct;70(8):906-12 20357895 - J Soc Clin Psychol. 2009 Feb 1;28(2):223-243 8255414 - Neuropsychobiology. 1993;28(1-2):76-81 19389582 - Immunol Allergy Clin North Am. 2009 May;29(2):285-93 16364058 - Psychophysiology. 2005 Nov;42(6):627-35 19409533 - Biol Psychiatry. 2009 Sep 1;66(5):415-22 14747646 - Psychosom Med. 2004 Jan-Feb;66(1):124-31 16724054 - Nature. 2006 May 25;441(7092):431-6 17873968 - Soc Cogn Affect Neurosci. 2007 Sep;2(3):227-39 2026843 - J Allergy Clin Immunol. 1991 May;87(5):893-910 17475444 - Brain Behav Immun. 2007 Oct;21(7):901-12 12880848 - Neuroimage. 2003 Jul;19(3):1233-9 19072897 - Hum Brain Mapp. 2009 Sep;30(9):2731-45 14551436 - Science. 2003 Oct 10;302(5643):290-2 16817529 - Behav Res Methods. 2006 Feb;38(1):174-80 19376240 - Neuroimage. 2009 Sep;47(3):881-90 17395493 - Neuroimage. 2007 May 1;35(4):1601-12 17576922 - Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11073-8 12840146 - Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9090-5 20035017 - Soc Cogn Affect Neurosci. 2009 Dec;4(4):423-8 14583231 - Brain Behav Immun. 2003 Dec;17(6):407-14 12154366 - Nat Rev Neurosci. 2002 Aug;3(8):655-66 15378203 - Cell Mol Life Sci. 2004 Sep;61(18):2322-31 9826273 - J Comp Neurol. 1998 Nov 30;401(4):455-79 19883137 - Psychol Bull. 2009 Nov;135(6):823-53 18039043 - Emotion. 2007 Nov;7(4):745-54 19693001 - Neuropsychopharmacology. 2010 Jan;35(1):192-216 14656310 - Eur J Neurosci. 2003 Dec;18(11):3134-44 16330726 - Arch Gen Psychiatry. 2005 Dec;62(12):1377-84 16215463 - J Neuropathol Exp Neurol. 2005 Oct;64(10):910-22 16761546 - Dev Psychopathol. 2005 Spring;17(2):271-301 15738954 - Nat Rev Immunol. 2005 Mar;5(3):243-51 19073750 - Psychosom Med. 2009 Jan;71(1):57-62 16084839 - Biol Psychiatry. 2005 Aug 1;58(3):190-6 8675562 - J Clin Endocrinol Metab. 1996 Jul;81(7):2468-73 15157953 - Brain Behav Immun. 2004 Jul;18(4):361-7 20083138 - Neurosci Biobehav Rev. 2010 Sep;35(1):39-45 9665958 - Clin Diagn Lab Immunol. 1998 Jul;5(4):507-12 17925521 - JAMA. 2007 Oct 10;298(14):1685-7 12692859 - J Comp Neurol. 2003 Jun 2;460(3):425-49 12912762 - Arch Gen Psychiatry. 2003 Aug;60(8):789-96 17706915 - Brain Behav Immun. 2008 Jan;22(1):24-32 11259725 - N Engl J Med. 2001 Mar 22;344(12):907-16 15250815 - Psychol Bull. 2004 Jul;130(4):601-30 11771995 - Neuroimage. 2002 Jan;15(1):273-89 19481155 - Neuroimage. 2009 Sep;47(3):891-6 3050629 - Neurosci Biobehav Rev. 1988 Summer;12(2):123-37 19754527 - Psychol Sci. 2009 Oct;20(10):1237-44 1713648 - N Engl J Med. 1991 Aug 29;325(9):606-12 17536965 - J Cogn Neurosci. 2007 Jun;19(6):945-56 |
| References_xml | – reference: 11771995 - Neuroimage. 2002 Jan;15(1):273-89 – reference: 14583231 - Brain Behav Immun. 2003 Dec;17(6):407-14 – reference: 14656310 - Eur J Neurosci. 2003 Dec;18(11):3134-44 – reference: 14551436 - Science. 2003 Oct 10;302(5643):290-2 – reference: 2026843 - J Allergy Clin Immunol. 1991 May;87(5):893-910 – reference: 1713648 - N Engl J Med. 1991 Aug 29;325(9):606-12 – reference: 17873968 - Soc Cogn Affect Neurosci. 2007 Sep;2(3):227-39 – reference: 17706915 - Brain Behav Immun. 2008 Jan;22(1):24-32 – reference: 19754527 - Psychol Sci. 2009 Oct;20(10):1237-44 – reference: 17475444 - Brain Behav Immun. 2007 Oct;21(7):901-12 – reference: 16364058 - Psychophysiology. 2005 Nov;42(6):627-35 – reference: 15157953 - Brain Behav Immun. 2004 Jul;18(4):361-7 – reference: 16724054 - Nature. 2006 May 25;441(7092):431-6 – reference: 15265539 - Brain Behav Immun. 2004 Sep;18(5):458-67 – reference: 18039043 - Emotion. 2007 Nov;7(4):745-54 – reference: 12880848 - Neuroimage. 2003 Jul;19(3):1233-9 – reference: 19693001 - Neuropsychopharmacology. 2010 Jan;35(1):192-216 – reference: 20035017 - Soc Cogn Affect Neurosci. 2009 Dec;4(4):423-8 – reference: 19196810 - Psychosom Med. 2009 Apr;71(3):329-33 – reference: 3050629 - Neurosci Biobehav Rev. 1988 Summer;12(2):123-37 – reference: 19883137 - Psychol Bull. 2009 Nov;135(6):823-53 – reference: 18778779 - Neuroimage. 2009 Jan 1;44(1):213-22 – reference: 15738954 - Nat Rev Immunol. 2005 Mar;5(3):243-51 – reference: 19409533 - Biol Psychiatry. 2009 Sep 1;66(5):415-22 – reference: 19150053 - Biol Psychiatry. 2009 May 1;65(9):732-41 – reference: 20083138 - Neurosci Biobehav Rev. 2010 Sep;35(1):39-45 – reference: 9665958 - Clin Diagn Lab Immunol. 1998 Jul;5(4):507-12 – reference: 15378203 - Cell Mol Life Sci. 2004 Sep;61(18):2322-31 – reference: 19465135 - Neuroimage. 2009 Sep;47(3):836-51 – reference: 17536965 - J Cogn Neurosci. 2007 Jun;19(6):945-56 – reference: 9826273 - J Comp Neurol. 1998 Nov 30;401(4):455-79 – reference: 17576922 - Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11073-8 – reference: 19376240 - Neuroimage. 2009 Sep;47(3):881-90 – reference: 16330726 - Arch Gen Psychiatry. 2005 Dec;62(12):1377-84 – reference: 17395493 - Neuroimage. 2007 May 1;35(4):1601-12 – reference: 14747646 - Psychosom Med. 2004 Jan-Feb;66(1):124-31 – reference: 8675562 - J Clin Endocrinol Metab. 1996 Jul;81(7):2468-73 – reference: 17925521 - JAMA. 2007 Oct 10;298(14):1685-7 – reference: 12840146 - Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9090-5 – reference: 12154366 - Nat Rev Neurosci. 2002 Aug;3(8):655-66 – reference: 19073750 - Psychosom Med. 2009 Jan;71(1):57-62 – reference: 18282566 - Eur J Pharmacol. 2008 Apr 7;583(2-3):174-85 – reference: 18611955 - Am J Epidemiol. 2008 Sep 1;168(5):481-91; discussion 492-6 – reference: 9826274 - J Comp Neurol. 1998 Nov 30;401(4):480-505 – reference: 8255414 - Neuropsychobiology. 1993;28(1-2):76-81 – reference: 15250815 - Psychol Bull. 2004 Jul;130(4):601-30 – reference: 11259725 - N Engl J Med. 2001 Mar 22;344(12):907-16 – reference: 16557263 - Nat Rev Immunol. 2006 Apr;6(4):318-28 – reference: 12912762 - Arch Gen Psychiatry. 2003 Aug;60(8):789-96 – reference: 18799429 - Psychosom Med. 2008 Oct;70(8):906-12 – reference: 16761546 - Dev Psychopathol. 2005 Spring;17(2):271-301 – reference: 16817529 - Behav Res Methods. 2006 Feb;38(1):174-80 – reference: 19389582 - Immunol Allergy Clin North Am. 2009 May;29(2):285-93 – reference: 16084839 - Biol Psychiatry. 2005 Aug 1;58(3):190-6 – reference: 20357895 - J Soc Clin Psychol. 2009 Feb 1;28(2):223-243 – reference: 12692859 - J Comp Neurol. 2003 Jun 2;460(3):425-49 – reference: 16215463 - J Neuropathol Exp Neurol. 2005 Oct;64(10):910-22 – reference: 19072897 - Hum Brain Mapp. 2009 Sep;30(9):2731-45 – reference: 9600484 - JAMA. 1998 May 13;279(18):1477-82 – reference: 19481155 - Neuroimage. 2009 Sep;47(3):891-6 |
| SSID | ssj0009580 |
| Score | 2.4996724 |
| Snippet | Although stress-induced increases in inflammation have been implicated in several major disorders, including cardiovascular disease and depression, the... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 14817 |
| SubjectTerms | Adolescent Adult Brain - anatomy & histology Brain - physiopathology Depression Enzyme-Linked Immunosorbent Assay Exudates and Transudates - chemistry Female Humans Inflammation - physiopathology Interleukin-6 - analysis Interpersonal Relations Magnetic Resonance Imaging Male Mouth Mucosa - chemistry Neural Pathways - anatomy & histology Neural Pathways - physiology Receptors, Tumor Necrosis Factor, Type II - analysis Rejection (Psychology) Social Alienation - psychology Solubility Stress, Psychological - physiopathology Tumor Necrosis Factor-alpha - analysis Young Adult |
| Title | Neural sensitivity to social rejection is associated with inflammatory responses to social stress |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/20679216 https://www.proquest.com/docview/748962043 |
| Volume | 107 |
| WOSCitedRecordID | wos000281287600054&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV07T8MwELaAMrAA5Vle8sAAg9XYedieEEJULFQdQOoW2Y4tFYmkNIXfzzl2gQUxsGQ6R5F95_vs-_IdQpeptl5k0xHFc0myjDuiIZES6yRkO0N1wVTXbIKPx2I6lZPIzWkjrXK1J3YbddUYf0c-9CopXjs9vZm_Ed80yhdXYweNddRLAcl4p-ZT8UNzVwQxAklJkclkpezD0-G8Vq0nCAA4ymjCf4eXXZoZ7fzzA3fRdsSX-DY4RB-t2XoP9WMEt_gqykxf7yPldTnAtPUU9tBDAi8bHC7R8cK-dCStGs9arOIa2gr7e1sMXgmO9NoV6MGyY9nCy79Hhz9QDtDz6P7p7oHEhgvEQCguCZyyIeEDAATUk2jLdJpUuaXUOpbkTivuTFHxyigBOLHKDYAJ54nkEPdgJzU7RBt1U9tjhGHlU1MIRbWwmaNSC2eFzmiVMaUE4wOEV7NYgkP7KoWqbfPell_zOEBHYSXKeRDeKL3UvGS0OPl78CnaCnV-OCPzM9RzEMz2HG2aj-WsXVx0jgLP8eTxE3RHyfY |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Neural+sensitivity+to+social+rejection+is+associated+with+inflammatory+responses+to+social+stress&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+-+PNAS&rft.au=Slavich%2C+George+M&rft.au=Way%2C+Baldwin+M&rft.au=Eisenberger%2C+Naomi+I&rft.au=Taylor%2C+Shelley+E&rft.date=2010-08-17&rft.eissn=1091-6490&rft.volume=107&rft.issue=33&rft.spage=14817&rft_id=info:doi/10.1073%2Fpnas.1009164107&rft_id=info%3Apmid%2F20679216&rft_id=info%3Apmid%2F20679216&rft.externalDocID=20679216 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1091-6490&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1091-6490&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1091-6490&client=summon |