Regulation of SIRT1 and Its Roles in Inflammation

The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD + -dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that plays a role in modulating inflammation. SIRT1 affects multiple biological processes by deacetylating a variety of prote...

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Veröffentlicht in:	Frontiers in immunology Jg. 13; S. 831168
Hauptverfasser:	Yang, Yunshu, Liu, Yang, Wang, Yunwei, Chao, Yongyi, Zhang, Jinxin, Jia, Yanhui, Tie, Jun, Hu, Dahai
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media S.A 11.03.2022
Schlagworte:	enzyme activity gene regulation Histones - metabolism Humans Immunology inflammation Inflammation - metabolism NAD - metabolism post-translational modification SIRT1 Sirtuin 1 - genetics Sirtuin 1 - metabolism Sirtuins - metabolism post-translational modification gene regulation inflammation SIRT1 enzyme activity
ISSN:	1664-3224, 1664-3224
Online-Zugang:	Volltext
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Abstract	The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD + -dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that plays a role in modulating inflammation. SIRT1 affects multiple biological processes by deacetylating a variety of proteins including histones and non-histone proteins. Recent studies have revealed intimate links between SIRT1 and inflammation, while alterations to SIRT1 expression and activity have been linked to inflammatory diseases. In this review, we summarize the mechanisms that regulate SIRT1 expression, including upstream activators and suppressors that operate on the transcriptional and post-transcriptional levels. We also summarize factors that influence SIRT1 activity including the NAD + /NADH ratio, SIRT1 binding partners, and post-translational modifications. Furthermore, we underscore the role of SIRT1 in the development of inflammation by commenting on the proteins that are targeted for deacetylation by SIRT1. Finally, we highlight the potential for SIRT1-based therapeutics for inflammatory diseases.
AbstractList	The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that plays a role in modulating inflammation. SIRT1 affects multiple biological processes by deacetylating a variety of proteins including histones and non-histone proteins. Recent studies have revealed intimate links between SIRT1 and inflammation, while alterations to SIRT1 expression and activity have been linked to inflammatory diseases. In this review, we summarize the mechanisms that regulate SIRT1 expression, including upstream activators and suppressors that operate on the transcriptional and post-transcriptional levels. We also summarize factors that influence SIRT1 activity including the NAD+/NADH ratio, SIRT1 binding partners, and post-translational modifications. Furthermore, we underscore the role of SIRT1 in the development of inflammation by commenting on the proteins that are targeted for deacetylation by SIRT1. Finally, we highlight the potential for SIRT1-based therapeutics for inflammatory diseases. The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that plays a role in modulating inflammation. SIRT1 affects multiple biological processes by deacetylating a variety of proteins including histones and non-histone proteins. Recent studies have revealed intimate links between SIRT1 and inflammation, while alterations to SIRT1 expression and activity have been linked to inflammatory diseases. In this review, we summarize the mechanisms that regulate SIRT1 expression, including upstream activators and suppressors that operate on the transcriptional and post-transcriptional levels. We also summarize factors that influence SIRT1 activity including the NAD+/NADH ratio, SIRT1 binding partners, and post-translational modifications. Furthermore, we underscore the role of SIRT1 in the development of inflammation by commenting on the proteins that are targeted for deacetylation by SIRT1. Finally, we highlight the potential for SIRT1-based therapeutics for inflammatory diseases.The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that plays a role in modulating inflammation. SIRT1 affects multiple biological processes by deacetylating a variety of proteins including histones and non-histone proteins. Recent studies have revealed intimate links between SIRT1 and inflammation, while alterations to SIRT1 expression and activity have been linked to inflammatory diseases. In this review, we summarize the mechanisms that regulate SIRT1 expression, including upstream activators and suppressors that operate on the transcriptional and post-transcriptional levels. We also summarize factors that influence SIRT1 activity including the NAD+/NADH ratio, SIRT1 binding partners, and post-translational modifications. Furthermore, we underscore the role of SIRT1 in the development of inflammation by commenting on the proteins that are targeted for deacetylation by SIRT1. Finally, we highlight the potential for SIRT1-based therapeutics for inflammatory diseases. The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD -dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that plays a role in modulating inflammation. SIRT1 affects multiple biological processes by deacetylating a variety of proteins including histones and non-histone proteins. Recent studies have revealed intimate links between SIRT1 and inflammation, while alterations to SIRT1 expression and activity have been linked to inflammatory diseases. In this review, we summarize the mechanisms that regulate SIRT1 expression, including upstream activators and suppressors that operate on the transcriptional and post-transcriptional levels. We also summarize factors that influence SIRT1 activity including the NAD /NADH ratio, SIRT1 binding partners, and post-translational modifications. Furthermore, we underscore the role of SIRT1 in the development of inflammation by commenting on the proteins that are targeted for deacetylation by SIRT1. Finally, we highlight the potential for SIRT1-based therapeutics for inflammatory diseases. The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD + -dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that plays a role in modulating inflammation. SIRT1 affects multiple biological processes by deacetylating a variety of proteins including histones and non-histone proteins. Recent studies have revealed intimate links between SIRT1 and inflammation, while alterations to SIRT1 expression and activity have been linked to inflammatory diseases. In this review, we summarize the mechanisms that regulate SIRT1 expression, including upstream activators and suppressors that operate on the transcriptional and post-transcriptional levels. We also summarize factors that influence SIRT1 activity including the NAD + /NADH ratio, SIRT1 binding partners, and post-translational modifications. Furthermore, we underscore the role of SIRT1 in the development of inflammation by commenting on the proteins that are targeted for deacetylation by SIRT1. Finally, we highlight the potential for SIRT1-based therapeutics for inflammatory diseases.
Author	Jia, Yanhui Yang, Yunshu Hu, Dahai Chao, Yongyi Zhang, Jinxin Tie, Jun Liu, Yang Wang, Yunwei
AuthorAffiliation	3 State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University , Xi’an , China 1 Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University , Xi’an , China 2 Department of Emergency, Xijing Hospital, Fourth Military Medical University , Xi’an , China
AuthorAffiliation_xml	– name: 1 Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University , Xi’an , China – name: 2 Department of Emergency, Xijing Hospital, Fourth Military Medical University , Xi’an , China – name: 3 State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University , Xi’an , China
Author_xml	– sequence: 1 givenname: Yunshu surname: Yang fullname: Yang, Yunshu – sequence: 2 givenname: Yang surname: Liu fullname: Liu, Yang – sequence: 3 givenname: Yunwei surname: Wang fullname: Wang, Yunwei – sequence: 4 givenname: Yongyi surname: Chao fullname: Chao, Yongyi – sequence: 5 givenname: Jinxin surname: Zhang fullname: Zhang, Jinxin – sequence: 6 givenname: Yanhui surname: Jia fullname: Jia, Yanhui – sequence: 7 givenname: Jun surname: Tie fullname: Tie, Jun – sequence: 8 givenname: Dahai surname: Hu fullname: Hu, Dahai
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/35359990$$D View this record in MEDLINE/PubMed
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Copyright	Copyright © 2022 Yang, Liu, Wang, Chao, Zhang, Jia, Tie and Hu. Copyright © 2022 Yang, Liu, Wang, Chao, Zhang, Jia, Tie and Hu 2022 Yang, Liu, Wang, Chao, Zhang, Jia, Tie and Hu
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Keywords	post-translational modification gene regulation inflammation SIRT1 enzyme activity
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Edited by: Bisheng Zhou, University of Illinois at Chicago, United States Reviewed by: Haiying Wang, Peking University, China; Jiaxiang Chen, Mayo Clinic, United States This article was submitted to Inflammation, a section of the journal Frontiers in Immunology These authors have contributed equally to this work and share first authorship
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Snippet	The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD + -dependent deacetylase belonging to the sirtuin family, is a... The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD -dependent deacetylase belonging to the sirtuin family, is a... The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-dependent deacetylase belonging to the sirtuin family, is a...
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SubjectTerms	enzyme activity gene regulation Histones - metabolism Humans Immunology inflammation Inflammation - metabolism NAD - metabolism post-translational modification SIRT1 Sirtuin 1 - genetics Sirtuin 1 - metabolism Sirtuins - metabolism
Title	Regulation of SIRT1 and Its Roles in Inflammation
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