Nodule size and fine-needle aspiration biopsy: diagnostic challenges for thyroid malignancy

To investigate the relationship between nodule size and malignancy and the correlation between the dimensional parameter and fine-needle aspiration biopsy (FNAB) in patients with a nodular goiter. Histological data of 415 patients who underwent thyroidectomy were used to estimate the actual nodule s...

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Vydáno v:The American journal of surgery Ročník 201; číslo 4; s. 525 - 530
Hlavní autoři: Rausei, Stefano, Dionigi, Gianlorenzo, Frattini, Francesco, Castano, Patrizia, Leotta, Andrea, Rovera, Francesca, Boni, Luigi, Bartalena, Luigi, Dionigi, Renzo
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York, NY Elsevier Inc 01.04.2011
Elsevier
Elsevier Limited
Témata:
Adult
Aged
Benign
Biological and medical sciences
Biopsy
Biopsy, Fine-Needle - methods
Cellular biology
Diagnostic systems
Endocrinopathies
Family medical history
Female
Fine-needle aspiration biopsy
General aspects
Goiter
Goiter, Nodular - pathology
Goiter, Nodular - surgery
Histology
Humans
Male
Malignancy
Medical sciences
Middle Aged
Multivariate analysis
Nodular goiter
Nodule size
Nodules
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Patients
Predictive factors
Reproducibility of Results
Retrospective Studies
Statistical analysis
Studies
Surgery
Thyroid
Thyroid cancer
Thyroid Gland - pathology
Thyroid malignancy
Thyroid Nodule - pathology
Thyroid. Thyroid axis (diseases)
Thyroidectomy
Tumor Burden
Tumors
Ultrasonic imaging
Nodular goiter
Nodule size
Thyroid malignancy
Predictive factors
Fine-needle aspiration biopsy
Endocrinopathy
Endocrine gland
Size
Thyroid diseases
Malignancy
Thyroid gland
Malignant tumor
Nodule
Fine needle aspiration biopsy
Medicine
Treatment
Surgery
Diagnosis
Predictive factor
Cancer
ISSN:0002-9610, 1879-1883, 1879-1883
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Shrnutí:To investigate the relationship between nodule size and malignancy and the correlation between the dimensional parameter and fine-needle aspiration biopsy (FNAB) in patients with a nodular goiter. Histological data of 415 patients who underwent thyroidectomy were used to estimate the actual nodule size and the difference between the diameter of the nodular lesion and the included tumor (intranodular peritumoral tissue [IPT]). FNAB was performed in 338 patients, and its predictive role was evaluated in comparison with histology. The histology revealed 207 cases of thyroid malignancy. The mean nodule size was significantly larger in benign disease compared with malignant. Only age and FNAB malignant category were independently associated with malignancy. The IPT showed a trend toward a statistically significant association with FNAB malignant category. Nodule size does not appear to be a reliable parameter to improve the clinical management of a nodular goiter because of a high variability between size of nodular area and tumor diameter.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0002-9610
1879-1883
1879-1883
DOI:10.1016/j.amjsurg.2010.03.008