Nodule size and fine-needle aspiration biopsy: diagnostic challenges for thyroid malignancy

To investigate the relationship between nodule size and malignancy and the correlation between the dimensional parameter and fine-needle aspiration biopsy (FNAB) in patients with a nodular goiter. Histological data of 415 patients who underwent thyroidectomy were used to estimate the actual nodule s...

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Veröffentlicht in:	The American journal of surgery Jg. 201; H. 4; S. 525 - 530
Hauptverfasser:	Rausei, Stefano, Dionigi, Gianlorenzo, Frattini, Francesco, Castano, Patrizia, Leotta, Andrea, Rovera, Francesca, Boni, Luigi, Bartalena, Luigi, Dionigi, Renzo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York, NY Elsevier Inc 01.04.2011 Elsevier Elsevier Limited
Schlagworte:	Adult Aged Benign Biological and medical sciences Biopsy Biopsy, Fine-Needle - methods Cellular biology Diagnostic systems Endocrinopathies Family medical history Female Fine-needle aspiration biopsy General aspects Goiter Goiter, Nodular - pathology Goiter, Nodular - surgery Histology Humans Male Malignancy Medical sciences Middle Aged Multivariate analysis Nodular goiter Nodule size Nodules Non tumoral diseases. Target tissue resistance. Benign neoplasms Patients Predictive factors Reproducibility of Results Retrospective Studies Statistical analysis Studies Surgery Thyroid Thyroid cancer Thyroid Gland - pathology Thyroid malignancy Thyroid Nodule - pathology Thyroid. Thyroid axis (diseases) Thyroidectomy Tumor Burden Tumors Ultrasonic imaging Nodular goiter Nodule size Thyroid malignancy Predictive factors Fine-needle aspiration biopsy Endocrinopathy Endocrine gland Size Thyroid diseases Malignancy Thyroid gland Malignant tumor Nodule Fine needle aspiration biopsy Medicine Treatment Surgery Diagnosis Predictive factor Cancer
ISSN:	0002-9610, 1879-1883, 1879-1883
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Abstract	To investigate the relationship between nodule size and malignancy and the correlation between the dimensional parameter and fine-needle aspiration biopsy (FNAB) in patients with a nodular goiter. Histological data of 415 patients who underwent thyroidectomy were used to estimate the actual nodule size and the difference between the diameter of the nodular lesion and the included tumor (intranodular peritumoral tissue [IPT]). FNAB was performed in 338 patients, and its predictive role was evaluated in comparison with histology. The histology revealed 207 cases of thyroid malignancy. The mean nodule size was significantly larger in benign disease compared with malignant. Only age and FNAB malignant category were independently associated with malignancy. The IPT showed a trend toward a statistically significant association with FNAB malignant category. Nodule size does not appear to be a reliable parameter to improve the clinical management of a nodular goiter because of a high variability between size of nodular area and tumor diameter.
AbstractList	To investigate the relationship between nodule size and malignancy and the correlation between the dimensional parameter and fine-needle aspiration biopsy (FNAB) in patients with a nodular goiter.BACKGROUNDTo investigate the relationship between nodule size and malignancy and the correlation between the dimensional parameter and fine-needle aspiration biopsy (FNAB) in patients with a nodular goiter.Histological data of 415 patients who underwent thyroidectomy were used to estimate the actual nodule size and the difference between the diameter of the nodular lesion and the included tumor (intranodular peritumoral tissue [IPT]). FNAB was performed in 338 patients, and its predictive role was evaluated in comparison with histology.METHODSHistological data of 415 patients who underwent thyroidectomy were used to estimate the actual nodule size and the difference between the diameter of the nodular lesion and the included tumor (intranodular peritumoral tissue [IPT]). FNAB was performed in 338 patients, and its predictive role was evaluated in comparison with histology.The histology revealed 207 cases of thyroid malignancy. The mean nodule size was significantly larger in benign disease compared with malignant. Only age and FNAB malignant category were independently associated with malignancy. The IPT showed a trend toward a statistically significant association with FNAB malignant category.RESULTSThe histology revealed 207 cases of thyroid malignancy. The mean nodule size was significantly larger in benign disease compared with malignant. Only age and FNAB malignant category were independently associated with malignancy. The IPT showed a trend toward a statistically significant association with FNAB malignant category.Nodule size does not appear to be a reliable parameter to improve the clinical management of a nodular goiter because of a high variability between size of nodular area and tumor diameter.CONCLUSIONSNodule size does not appear to be a reliable parameter to improve the clinical management of a nodular goiter because of a high variability between size of nodular area and tumor diameter. To investigate the relationship between nodule size and malignancy and the correlation between the dimensional parameter and fine-needle aspiration biopsy (FNAB) in patients with a nodular goiter. Histological data of 415 patients who underwent thyroidectomy were used to estimate the actual nodule size and the difference between the diameter of the nodular lesion and the included tumor (intranodular peritumoral tissue [IPT]). FNAB was performed in 338 patients, and its predictive role was evaluated in comparison with histology. The histology revealed 207 cases of thyroid malignancy. The mean nodule size was significantly larger in benign disease compared with malignant. Only age and FNAB malignant category were independently associated with malignancy. The IPT showed a trend toward a statistically significant association with FNAB malignant category. Nodule size does not appear to be a reliable parameter to improve the clinical management of a nodular goiter because of a high variability between size of nodular area and tumor diameter. Background To investigate the relationship between nodule size and malignancy and the correlation between the dimensional parameter and fine-needle aspiration biopsy (FNAB) in patients with a nodular goiter. Methods Histological data of 415 patients who underwent thyroidectomy were used to estimate the actual nodule size and the difference between the diameter of the nodular lesion and the included tumor (intranodular peritumoral tissue [IPT]). FNAB was performed in 338 patients, and its predictive role was evaluated in comparison with histology. Results The histology revealed 207 cases of thyroid malignancy. The mean nodule size was significantly larger in benign disease compared with malignant. Only age and FNAB malignant category were independently associated with malignancy. The IPT showed a trend toward a statistically significant association with FNAB malignant category. Conclusions Nodule size does not appear to be a reliable parameter to improve the clinical management of a nodular goiter because of a high variability between size of nodular area and tumor diameter. Abstract Background To investigate the relationship between nodule size and malignancy and the correlation between the dimensional parameter and fine-needle aspiration biopsy (FNAB) in patients with a nodular goiter. Methods Histological data of 415 patients who underwent thyroidectomy were used to estimate the actual nodule size and the difference between the diameter of the nodular lesion and the included tumor (intranodular peritumoral tissue [IPT]). FNAB was performed in 338 patients, and its predictive role was evaluated in comparison with histology. Results The histology revealed 207 cases of thyroid malignancy. The mean nodule size was significantly larger in benign disease compared with malignant. Only age and FNAB malignant category were independently associated with malignancy. The IPT showed a trend toward a statistically significant association with FNAB malignant category. Conclusions Nodule size does not appear to be a reliable parameter to improve the clinical management of a nodular goiter because of a high variability between size of nodular area and tumor diameter.
Author	Bartalena, Luigi Rausei, Stefano Boni, Luigi Dionigi, Renzo Rovera, Francesca Dionigi, Gianlorenzo Frattini, Francesco Castano, Patrizia Leotta, Andrea
Author_xml	– sequence: 1 givenname: Stefano surname: Rausei fullname: Rausei, Stefano email: s.rausei@libero.it organization: Department of Surgical Sciences, University of Insubria, Viale L, Borri 57, Italian Republic, 21100 Varese, Italy – sequence: 2 givenname: Gianlorenzo surname: Dionigi fullname: Dionigi, Gianlorenzo organization: Department of Surgical Sciences, University of Insubria, Viale L, Borri 57, Italian Republic, 21100 Varese, Italy – sequence: 3 givenname: Francesco surname: Frattini fullname: Frattini, Francesco organization: Department of Surgical Sciences, University of Insubria, Viale L, Borri 57, Italian Republic, 21100 Varese, Italy – sequence: 4 givenname: Patrizia surname: Castano fullname: Castano, Patrizia organization: Department of Surgical Sciences, University of Insubria, Viale L, Borri 57, Italian Republic, 21100 Varese, Italy – sequence: 5 givenname: Andrea surname: Leotta fullname: Leotta, Andrea organization: Department of Surgical Sciences, University of Insubria, Viale L, Borri 57, Italian Republic, 21100 Varese, Italy – sequence: 6 givenname: Francesca surname: Rovera fullname: Rovera, Francesca organization: Department of Surgical Sciences, University of Insubria, Viale L, Borri 57, Italian Republic, 21100 Varese, Italy – sequence: 7 givenname: Luigi surname: Boni fullname: Boni, Luigi organization: Department of Surgical Sciences, University of Insubria, Viale L, Borri 57, Italian Republic, 21100 Varese, Italy – sequence: 8 givenname: Luigi surname: Bartalena fullname: Bartalena, Luigi organization: Division of Endocrinology, Department of Clinical Medicine, University of Insubria, Varese, Italy – sequence: 9 givenname: Renzo surname: Dionigi fullname: Dionigi, Renzo organization: Department of Surgical Sciences, University of Insubria, Viale L, Borri 57, Italian Republic, 21100 Varese, Italy
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Keywords	Nodular goiter Nodule size Thyroid malignancy Predictive factors Fine-needle aspiration biopsy Endocrinopathy Endocrine gland Size Thyroid diseases Malignancy Thyroid gland Malignant tumor Nodule Fine needle aspiration biopsy Medicine Treatment Surgery Diagnosis Predictive factor Cancer
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Snippet	To investigate the relationship between nodule size and malignancy and the correlation between the dimensional parameter and fine-needle aspiration biopsy... Abstract Background To investigate the relationship between nodule size and malignancy and the correlation between the dimensional parameter and fine-needle... Background To investigate the relationship between nodule size and malignancy and the correlation between the dimensional parameter and fine-needle aspiration...
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SubjectTerms	Adult Aged Benign Biological and medical sciences Biopsy Biopsy, Fine-Needle - methods Cellular biology Diagnostic systems Endocrinopathies Family medical history Female Fine-needle aspiration biopsy General aspects Goiter Goiter, Nodular - pathology Goiter, Nodular - surgery Histology Humans Male Malignancy Medical sciences Middle Aged Multivariate analysis Nodular goiter Nodule size Nodules Non tumoral diseases. Target tissue resistance. Benign neoplasms Patients Predictive factors Reproducibility of Results Retrospective Studies Statistical analysis Studies Surgery Thyroid Thyroid cancer Thyroid Gland - pathology Thyroid malignancy Thyroid Nodule - pathology Thyroid. Thyroid axis (diseases) Thyroidectomy Tumor Burden Tumors Ultrasonic imaging
Title	Nodule size and fine-needle aspiration biopsy: diagnostic challenges for thyroid malignancy
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