Factors associated with spontaneous HBsAg clearance in chronic hepatitis B patients followed at a university hospital

Few studies have evaluated the factors involved in the spontaneous HBsAg seroclearance in patients with chronic hepatitis B (HBV) followed up on a long-term basis from areas with a low prevalence of HBV infection. We aimed to determine the rate of spontaneous HBsAg seroclearance and the factors rela...

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Vydané v:Annals of hepatology Ročník 13; číslo 6; s. 762 - 770
Hlavní autori: Ferreira, Sandro C, Chachá, Silvana G F, Souza, Fernanda F, Teixeira, Andreza C, Santana, Rodrigo C, Villanova, Márcia G, Zucoloto, Sérgio, Ramalho, Leandra N, Perdoná, Gleici S C, Passos, Afonso D C, Martinelli, Ana L C
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Mexico Elsevier 01.11.2014
Predmet:
Adult
Age
Age Factors
Carrier State
Disease Progression
DNA, Viral - blood
Evolutionary forms
Female
HBV-DNA levels
Hepatitis B Antibodies - immunology
Hepatitis B e Antigens - blood
Hepatitis B e Antigens - immunology
Hepatitis B Surface Antigens - blood
Hepatitis B Surface Antigens - immunology
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Hepatitis B, Chronic - blood
Hepatitis B, Chronic - immunology
Humans
Inactive carriers
Low prevalence areas
Male
Middle Aged
Retrospective Studies
Sex Factors
Young Adult
ISSN:1665-2681
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Shrnutí:Few studies have evaluated the factors involved in the spontaneous HBsAg seroclearance in patients with chronic hepatitis B (HBV) followed up on a long-term basis from areas with a low prevalence of HBV infection. We aimed to determine the rate of spontaneous HBsAg seroclearance and the factors related to it in patients with chronic HBV infection followed up at the Hepatitis Outpatient Clinic of HCFMRP from 1992-2008. A total of 548 patients with chronic HBV infection (366 with chronic hepatitis B and 182 inactive carriers) were followed for 15 years and 9 months with an annual measurement of HBV-DNA, ALT, AST and GGT (average of 4 annual determinations) and serology (HBsAg, HBeAg, Anti-HBeAg and Anti-HBsAg). Spontaneous HBsAg seroclearance occurred in 40 patients (7.3%) with a mean age of 46.0 ± 14.4 years, corresponding to an annual rate of 0.7%.The factors related to spontaneous HBsAg seroclearance were inactive carrier status (67.5 vs. 32.5%, p = 0.000191) and age of more than 40 years (p = 0.0007). There was no difference in the rate of spontaneous HBsAg seroclearance when comparing males and females (p = 0.383). Patients with spontaneous HBsAg seroclearance did not progress to more severe forms of the disease during follow-up. Spontaneous HBsAg seroclearance has a favorable long-term prognosis in patients with chronic HBV infection. HBsAg seroclearance occurred at rates compatible with low prevalence areas and was associated with low serum HBV-DNA levels and an age older than 40 years.
Bibliografia:ObjectType-Article-1
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ISSN:1665-2681
DOI:10.1016/S1665-2681(19)30978-0