The chemistry and biological activities of N-acetylcysteine

N-acetylcysteine (NAC) has been in clinical practice for several decades. It has been used as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication, doxorubicin cardiotoxicity, ischemia–reperfusion cardiac injury, acute respiratory distress syndrome, bronch...

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Vydáno v:	Biochimica et biophysica acta Ročník 1830; číslo 8; s. 4117 - 4129
Hlavní autoři:	Samuni, Yuval, Goldstein, Sara, Dean, Olivia M., Berk, Michael
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier B.V 01.08.2013
Témata:	acetaminophen acetylcysteine Acetylcysteine - chemistry Acetylcysteine - metabolism Acetylcysteine - pharmacology Animals Antioxidant antioxidant activity Apoptosis - drug effects behavior disorders Blood-Brain Barrier bronchitis Cell Cycle - drug effects Cell Membrane - metabolism cell membranes Cell-permeability cysteine distress Disulfide bond disulfide bonds doxorubicin Glutathione precursor heavy metals Human immunodeficiency virus Humans hydrogen peroxide Mental Disorders - drug therapy N-acetylcysteine nitrogen dioxide poisoning proteins Redox potential signal transduction Signal Transduction - drug effects thiols toxicity NO RS BBB O2 CO3 HNO HOSCN Glutathione precursor TNF INF-γ LPS N-acetylcysteine NO2 NF-κB RNS mTOR OH GSH CD IL N3 RSH IKK SOD Antioxidant I-κB PMN HOCl MMP NAC Disulfide bond ROS Redox potential NAPQI RSOH Ig Cell-permeability ERK
ISSN:	0304-4165, 0006-3002, 1872-8006
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