Immunotherapy Goes Local: The Central Role of Lymph Nodes in Driving Tumor Infiltration and Efficacy

Immune checkpoint blockade (ICB) has changed the therapeutic landscape of oncology but its impact is limited by primary or secondary resistance. ICB resistance has been related to a lack of T cells infiltrating into the tumor. Strategies to overcome this hurdle have so far focused on the tumor micro...

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Veröffentlicht in:	Frontiers in immunology Jg. 12; S. 643291
Hauptverfasser:	van Pul, Kim M., Fransen, Marieke F., van de Ven, Rieneke, de Gruijl, Tanja D.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media S.A 01.03.2021
Schlagworte:	cancer dendritic cell Humans immune check point immune exclusion Immunity, Cellular Immunology Immunotherapy Lymph Nodes - immunology Lymph Nodes - pathology Lymphatic Metastasis Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - pathology Neoplasms - immunology Neoplasms - pathology Neoplasms - therapy t cell exhaustion T-Lymphocytes - immunology T-Lymphocytes - pathology tumor draining lymph node t cell exhaustion immune check point tumor draining lymph node immune exclusion CTLA-4 cancer PD-1 dendritic cell
ISSN:	1664-3224, 1664-3224
Online-Zugang:	Volltext
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