Cysteine cathepsins and extracellular matrix degradation

Cysteine cathepsins are normally found in the lysosomes where they are involved in intracellular protein turnover. Their ability to degrade the components of the extracellular matrix in vitro was first reported more than 25years ago. However, cathepsins were for a long time not considered to be amon...

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Vydáno v:	Biochimica et biophysica acta Ročník 1840; číslo 8; s. 2560 - 2570
Hlavní autoři:	Fonović, Marko, Turk, Boris
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier B.V 01.08.2014
Témata:	acidification Animals bone resorption cardiovascular diseases Cathepsin cathepsin K Cathepsins - chemistry Cathepsins - metabolism Collagen cysteine Cysteine - metabolism drugs elastin Extracellular matrix Extracellular Matrix - metabolism Glycosaminoglycan Humans Lysosome lysosomes Molecular Targeted Therapy neoplasms Osteoporosis protein metabolism secretion Substrate Specificity Osteoporosis Extracellular matrix Glycosaminoglycan Cathepsin Collagen Lysosome
ISSN:	0304-4165, 0006-3002, 1872-8006
On-line přístup:	Získat plný text
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