Cysteine cathepsins and extracellular matrix degradation

Cysteine cathepsins are normally found in the lysosomes where they are involved in intracellular protein turnover. Their ability to degrade the components of the extracellular matrix in vitro was first reported more than 25years ago. However, cathepsins were for a long time not considered to be amon...

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Veröffentlicht in:	Biochimica et biophysica acta Jg. 1840; H. 8; S. 2560 - 2570
Hauptverfasser:	Fonović, Marko, Turk, Boris
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.08.2014
Schlagworte:	acidification Animals bone resorption cardiovascular diseases Cathepsin cathepsin K Cathepsins - chemistry Cathepsins - metabolism Collagen cysteine Cysteine - metabolism drugs elastin Extracellular matrix Extracellular Matrix - metabolism Glycosaminoglycan Humans Lysosome lysosomes Molecular Targeted Therapy neoplasms Osteoporosis protein metabolism secretion Substrate Specificity Osteoporosis Extracellular matrix Glycosaminoglycan Cathepsin Collagen Lysosome
ISSN:	0304-4165, 0006-3002, 1872-8006
Online-Zugang:	Volltext
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