Metabolic Reprogramming in Tumor-Associated Macrophages in the Ovarian Tumor Microenvironment

The interaction between tumor cells and macrophages in the tumor microenvironment plays an essential role in metabolic changes in macrophages and reprograms them towards a pro-tumorigenic phenotype. Increasing evidence indicates that macrophage metabolism is a highly complex process and may not be a...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cancers Ročník 14; číslo 21; s. 5224
Hlavní autoři: Kumar, Sudhir, Mittal, Sonam, Gupta, Prachi, Singh, Mona, Chaluvally-Raghavan, Pradeep, Pradeep, Sunila
Médium: Journal Article
Jazyk:angličtina
Vydáno: Basel MDPI AG 25.10.2022
MDPI
Témata:
Adipocytes
Angiogenesis
Ascites
Cell metabolism
Cytokines
Development and progression
Drug resistance
Fatty acids
Genotype & phenotype
Glucose
Glycolysis
Health aspects
Hypoxia
Inflammation
Kinases
Lipids
Macrophages
Malignancy
Medical prognosis
Metabolic pathways
Metabolism
Metabolites
Metastases
Metastasis
Ovarian cancer
Ovarian tumors
Oxidative phosphorylation
Phenotypes
Phosphorylation
Review
Tumor cells
Tumor microenvironment
Tumorigenesis
Tumors
Vascular endothelial growth factor
United States
ISSN:2072-6694, 2072-6694
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:The interaction between tumor cells and macrophages in the tumor microenvironment plays an essential role in metabolic changes in macrophages and reprograms them towards a pro-tumorigenic phenotype. Increasing evidence indicates that macrophage metabolism is a highly complex process and may not be as simple as previously thought. Pro-inflammatory stimuli switch macrophages towards an M1-like phenotype and rely mainly on aerobic glycolysis and fatty acid synthesis, whereas anti-inflammatory stimuli switch macrophages towards an M2-like phenotype. M2-like macrophages depend more on oxidative phosphorylation (OXPHOS) and fatty acid oxidation. However, this metabolically reprogrammed phenotypic switch in macrophages remained a mystery for a while. Therefore, through this review, we tend to describe how macrophage immunometabolism determines macrophage phenotypes and functions in tumor microenvironments (TMEs). Furthermore, we have discussed how metabolic reprogramming in TAM can be used for therapeutic intervention and drug resistance in ovarian cancer.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14215224