Comparison of pharmacokinetic profile of levodopa throughout the day between levodopa/carbidopa/entacapone and levodopa/carbidopa when administered four or five times daily

Objectives To compare plasma levodopa concentrations after repeated doses of levodopa/carbidopa/entacapone (LCE) and levodopa/carbidopa (LC). Methods Open-label, randomized, two-period, active-controlled, cross-over study with four dosing regimens: groups I and II (healthy volunteers and Parkinson&#...

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Bibliographic Details
Published in:	European journal of clinical pharmacology Vol. 65; no. 5; pp. 443 - 455
Main Authors:	Kuoppamäki, Mikko, Korpela, Kirsi, Marttila, Reijo, Kaasinen, Valtteri, Hartikainen, Päivi, Lyytinen, Jukka, Kaakkola, Seppo, Hänninen, Jutta, Löyttyniemi, Eliisa, Kailajärvi, Marita, Ruokoniemi, Päivi, Ellmén, Juha
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.05.2009 Springer-Verlag Springer Springer Nature B.V Springer Verlag
Subjects:	administration & dosage Administration, Oral Adolescent Adult Antiparkinson Agents Antiparkinson Agents - administration & dosage Antiparkinson Agents - blood Antiparkinson Agents - pharmacokinetics Area Under Curve Biological and medical sciences Biomedical and Life Sciences Biomedicine blood Carbidopa Carbidopa - administration & dosage Carbidopa - blood Carbidopa - pharmacokinetics Case-Control Studies Catechol O-Methyltransferase Catechol O-Methyltransferase - metabolism Catechol O-Methyltransferase Inhibitors Catechols Catechols - administration & dosage Catechols - blood Catechols - pharmacokinetics Clinical outcomes Clinical Trial Clinical trials Comparative studies Cross-Over Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dose-Response Relationship, Drug Drug Combinations Drug Interactions Entacapone Female Half-Life Humans L-dopa Levodopa Levodopa - administration & dosage Levodopa - blood Levodopa - pharmacokinetics Male Medical sciences Metabolic Clearance Rate metabolism Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Nitriles Nitriles - administration & dosage Nitriles - blood Nitriles - pharmacokinetics Parkinson disease Parkinsons disease pharmacokinetics Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Prescription drugs Young Adult Entacapone Levodopa Carbidopa Pharmacokinetics Parkinson’s disease Agonist Parkinson's disease Parkinson disease Catechol O-methyltransferase Lyases Carboxy-lyases Degenerative disease Human Decarboxylase Nervous system diseases Enzyme Transferases Enzyme inhibitor Antiparkinson agent Cerebral disorder Carbon-carbon lyases D2 Dopamine receptor Methyltransferases Central nervous system disease Comparative study Extrapyramidal syndrome
ISSN:	0031-6970, 1432-1041, 1432-1041
Online Access:	Get full text
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