Event-related potentials (MMN and novelty P3) in permanent vegetative or minimally conscious states

To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Event-related potential (ERP) mapping was performed on 27 patients in permanent (4–261 months after coma onset) vegetative (PVS, n = 16) or minimally conscious states (MCS, n = 11) due to anoxia ( n = 18) or o...

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Vydané v:Clinical neurophysiology Ročník 121; číslo 7; s. 1032 - 1042
Hlavní autori: Fischer, Catherine, Luaute, Jacques, Morlet, Dominique
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Oxford Elsevier Ireland Ltd 01.07.2010
Elsevier
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ISSN:1388-2457, 1872-8952, 1872-8952
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Abstract To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Event-related potential (ERP) mapping was performed on 27 patients in permanent (4–261 months after coma onset) vegetative (PVS, n = 16) or minimally conscious states (MCS, n = 11) due to anoxia ( n = 18) or other aetiologies ( n = 9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject’s own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded. MMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies. Irrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia. Some PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology.
AbstractList To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Event-related potential (ERP) mapping was performed on 27 patients in permanent (4-261 months after coma onset) vegetative (PVS, n=16) or minimally conscious states (MCS, n=11) due to anoxia (n=18) or other aetiologies (n=9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject's own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded. MMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies. Irrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia. Some PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology.
To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Event-related potential (ERP) mapping was performed on 27 patients in permanent (4–261 months after coma onset) vegetative (PVS, n = 16) or minimally conscious states (MCS, n = 11) due to anoxia ( n = 18) or other aetiologies ( n = 9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject’s own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded. MMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies. Irrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia. Some PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology.
Abstract Objective To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Methods Event-related potential (ERP) mapping was performed on 27 patients in permanent (4–261 months after coma onset) vegetative (PVS, n = 16) or minimally conscious states (MCS, n = 11) due to anoxia ( n = 18) or other aetiologies ( n = 9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject’s own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded. Results MMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies. Conclusions Irrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia. Significance Some PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology.
Objective - To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Methods - Event-related potential (ERP) mapping was performed on 27 patients in permanent (4-261 months after coma onset) vegetative (PVS, n = 16) or minimally conscious states (MCS, n = 11) due to anoxia (n = 18) or other aetiologies (n = 9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject's own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded. Results - MMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies. Conclusions - Irrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia. Significance - Some PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology.
To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS).OBJECTIVETo assess markers of cognition, if any, in patients in a permanent vegetative state (PVS).Event-related potential (ERP) mapping was performed on 27 patients in permanent (4-261 months after coma onset) vegetative (PVS, n=16) or minimally conscious states (MCS, n=11) due to anoxia (n=18) or other aetiologies (n=9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject's own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded.METHODSEvent-related potential (ERP) mapping was performed on 27 patients in permanent (4-261 months after coma onset) vegetative (PVS, n=16) or minimally conscious states (MCS, n=11) due to anoxia (n=18) or other aetiologies (n=9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject's own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded.MMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies.RESULTSMMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies.Irrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia.CONCLUSIONSIrrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia.Some PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology.SIGNIFICANCESome PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology.
Author Fischer, Catherine
Luaute, Jacques
Morlet, Dominique
Author_xml – sequence: 1
  givenname: Catherine
  surname: Fischer
  fullname: Fischer, Catherine
  email: catherine.fischer@chu-lyon.fr
  organization: Hospices Civils de Lyon, Neurological Hospital, Department of Clinical Neurophysiology, Lyon, France
– sequence: 2
  givenname: Jacques
  surname: Luaute
  fullname: Luaute, Jacques
  organization: Université Lyon 1, Lyon, F-69000, France
– sequence: 3
  givenname: Dominique
  surname: Morlet
  fullname: Morlet, Dominique
  organization: INSERM U 821 (Brain Dynamics and Cognition), Lyon, F-69500, France
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ContentType Journal Article
Copyright 2010 International Federation of Clinical Neurophysiology
International Federation of Clinical Neurophysiology
2015 INIST-CNRS
Copyright 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Copyright 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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– notice: International Federation of Clinical Neurophysiology
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– notice: Copyright 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
– notice: Copyright 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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ISSN 1388-2457
1872-8952
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IsPeerReviewed true
IsScholarly true
Issue 7
Keywords ERPs
P3
Anoxia
Vegetative state
Consciousness
MMN
Coma
Awareness
Central nervous system
Electrophysiology
Cognition
Encephalon
Electrodiagnosis
Mismatch negativity
Acoustic stimulus
Neurological disorder
Novelty
Human
Oxygen
Nervous system diseases
Consciousness impairment
Sound
Onset time
Auditory evoked potential
Event evoked potential
Language English
License CC BY 4.0
Copyright 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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– reference: 20202898 - Clin Neurophysiol. 2010 Jul;121(7):992-3
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Snippet To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Event-related potential (ERP) mapping was performed on 27 patients...
Abstract Objective To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Methods Event-related potential (ERP) mapping was...
To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS).OBJECTIVETo assess markers of cognition, if any, in patients in a...
Objective - To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Methods - Event-related potential (ERP) mapping was...
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SourceType Aggregation Database
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Enrichment Source
Publisher
StartPage 1032
SubjectTerms Acoustic Stimulation - methods
Adult
Aged
Anoxia
Behavioral psychophysiology
Biological and medical sciences
Consciousness
Electrodiagnosis. Electric activity recording
Electrophysiology
ERPs
Event-Related Potentials, P300 - physiology
Evoked Potentials, Auditory - physiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
MMN
Nervous system
Neurology
Persistent Vegetative State - diagnosis
Persistent Vegetative State - physiopathology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Vegetative state
Young Adult
Title Event-related potentials (MMN and novelty P3) in permanent vegetative or minimally conscious states
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