Event-related potentials (MMN and novelty P3) in permanent vegetative or minimally conscious states
To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Event-related potential (ERP) mapping was performed on 27 patients in permanent (4–261 months after coma onset) vegetative (PVS, n = 16) or minimally conscious states (MCS, n = 11) due to anoxia ( n = 18) or o...
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| Vydané v: | Clinical neurophysiology Ročník 121; číslo 7; s. 1032 - 1042 |
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| Hlavní autori: | , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Oxford
Elsevier Ireland Ltd
01.07.2010
Elsevier |
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| ISSN: | 1388-2457, 1872-8952, 1872-8952 |
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| Abstract | To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS).
Event-related potential (ERP) mapping was performed on 27 patients in permanent (4–261
months after coma onset) vegetative (PVS,
n
=
16) or minimally conscious states (MCS,
n
=
11) due to anoxia (
n
=
18) or other aetiologies (
n
=
9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject’s own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded.
MMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies.
Irrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia.
Some PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology. |
|---|---|
| AbstractList | To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS).
Event-related potential (ERP) mapping was performed on 27 patients in permanent (4-261 months after coma onset) vegetative (PVS, n=16) or minimally conscious states (MCS, n=11) due to anoxia (n=18) or other aetiologies (n=9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject's own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded.
MMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies.
Irrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia.
Some PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology. To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Event-related potential (ERP) mapping was performed on 27 patients in permanent (4–261 months after coma onset) vegetative (PVS, n = 16) or minimally conscious states (MCS, n = 11) due to anoxia ( n = 18) or other aetiologies ( n = 9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject’s own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded. MMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies. Irrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia. Some PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology. Abstract Objective To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Methods Event-related potential (ERP) mapping was performed on 27 patients in permanent (4–261 months after coma onset) vegetative (PVS, n = 16) or minimally conscious states (MCS, n = 11) due to anoxia ( n = 18) or other aetiologies ( n = 9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject’s own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded. Results MMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies. Conclusions Irrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia. Significance Some PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology. Objective - To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Methods - Event-related potential (ERP) mapping was performed on 27 patients in permanent (4-261 months after coma onset) vegetative (PVS, n = 16) or minimally conscious states (MCS, n = 11) due to anoxia (n = 18) or other aetiologies (n = 9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject's own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded. Results - MMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies. Conclusions - Irrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia. Significance - Some PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology. To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS).OBJECTIVETo assess markers of cognition, if any, in patients in a permanent vegetative state (PVS).Event-related potential (ERP) mapping was performed on 27 patients in permanent (4-261 months after coma onset) vegetative (PVS, n=16) or minimally conscious states (MCS, n=11) due to anoxia (n=18) or other aetiologies (n=9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject's own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded.METHODSEvent-related potential (ERP) mapping was performed on 27 patients in permanent (4-261 months after coma onset) vegetative (PVS, n=16) or minimally conscious states (MCS, n=11) due to anoxia (n=18) or other aetiologies (n=9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject's own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded.MMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies.RESULTSMMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies.Irrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia.CONCLUSIONSIrrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia.Some PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology.SIGNIFICANCESome PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology. |
| Author | Fischer, Catherine Luaute, Jacques Morlet, Dominique |
| Author_xml | – sequence: 1 givenname: Catherine surname: Fischer fullname: Fischer, Catherine email: catherine.fischer@chu-lyon.fr organization: Hospices Civils de Lyon, Neurological Hospital, Department of Clinical Neurophysiology, Lyon, France – sequence: 2 givenname: Jacques surname: Luaute fullname: Luaute, Jacques organization: Université Lyon 1, Lyon, F-69000, France – sequence: 3 givenname: Dominique surname: Morlet fullname: Morlet, Dominique organization: INSERM U 821 (Brain Dynamics and Cognition), Lyon, F-69500, France |
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| Keywords | ERPs P3 Anoxia Vegetative state Consciousness MMN Coma Awareness Central nervous system Electrophysiology Cognition Encephalon Electrodiagnosis Mismatch negativity Acoustic stimulus Neurological disorder Novelty Human Oxygen Nervous system diseases Consciousness impairment Sound Onset time Auditory evoked potential Event evoked potential |
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| PublicationTitle | Clinical neurophysiology |
| PublicationTitleAlternate | Clin Neurophysiol |
| PublicationYear | 2010 |
| Publisher | Elsevier Ireland Ltd Elsevier |
| Publisher_xml | – name: Elsevier Ireland Ltd – name: Elsevier |
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| Snippet | To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS).
Event-related potential (ERP) mapping was performed on 27 patients... Abstract Objective To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Methods Event-related potential (ERP) mapping was... To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS).OBJECTIVETo assess markers of cognition, if any, in patients in a... Objective - To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Methods - Event-related potential (ERP) mapping was... |
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| SubjectTerms | Acoustic Stimulation - methods Adult Aged Anoxia Behavioral psychophysiology Biological and medical sciences Consciousness Electrodiagnosis. Electric activity recording Electrophysiology ERPs Event-Related Potentials, P300 - physiology Evoked Potentials, Auditory - physiology Female Fundamental and applied biological sciences. Psychology Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged MMN Nervous system Neurology Persistent Vegetative State - diagnosis Persistent Vegetative State - physiopathology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Vegetative state Young Adult |
| Title | Event-related potentials (MMN and novelty P3) in permanent vegetative or minimally conscious states |
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