Event-related potentials (MMN and novelty P3) in permanent vegetative or minimally conscious states

To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Event-related potential (ERP) mapping was performed on 27 patients in permanent (4–261 months after coma onset) vegetative (PVS, n = 16) or minimally conscious states (MCS, n = 11) due to anoxia ( n = 18) or o...

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Published in:Clinical neurophysiology Vol. 121; no. 7; pp. 1032 - 1042
Main Authors: Fischer, Catherine, Luaute, Jacques, Morlet, Dominique
Format: Journal Article
Language:English
Published: Oxford Elsevier Ireland Ltd 01.07.2010
Elsevier
Subjects:
Acoustic Stimulation - methods
Adult
Aged
Anoxia
Behavioral psychophysiology
Biological and medical sciences
Consciousness
Electrodiagnosis. Electric activity recording
Electrophysiology
ERPs
Event-Related Potentials, P300 - physiology
Evoked Potentials, Auditory - physiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
MMN
Nervous system
Neurology
Persistent Vegetative State - diagnosis
Persistent Vegetative State - physiopathology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Vegetative state
Young Adult
ERPs
P3
Anoxia
Vegetative state
Consciousness
MMN
Coma
Awareness
Central nervous system
Electrophysiology
Cognition
Encephalon
Electrodiagnosis
Mismatch negativity
Acoustic stimulus
Neurological disorder
Novelty
Human
Oxygen
Nervous system diseases
Consciousness impairment
Sound
Onset time
Auditory evoked potential
Event evoked potential
ISSN:1388-2457, 1872-8952, 1872-8952
Online Access:Get full text
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Summary:To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS). Event-related potential (ERP) mapping was performed on 27 patients in permanent (4–261 months after coma onset) vegetative (PVS, n = 16) or minimally conscious states (MCS, n = 11) due to anoxia ( n = 18) or other aetiologies ( n = 9). Mismatch negativity (MMN) to duration-deviant tones and novelty P3 (nP3) to the subject’s own name were recorded according to a paradigm previously validated in healthy volunteers and comatose patients. SEPs, MLAEPs and BAEPs were also recorded. MMN was present in 5/27 and nP3 in 7/27 patients. ERPs were not related to the time from coma onset and not different in MCS and in PVS. Normal SEPs and MLAEPs, and present nP3s were less frequent in anoxia than in other aetiologies. Irrespective of their clinical assessment, a few patients are likely to process sound deviance (MMN) or novelty (nP3), mainly when their state is not due to anoxia. Some PVS patients may be able to put certain awareness marker processes to work. The diagnostic criteria for PVS or MCS, currently based on mere behaviour, should also include functional brain investigations, such as ERPs, related to the aetiology.
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ISSN:1388-2457
1872-8952
1872-8952
DOI:10.1016/j.clinph.2010.02.005