Quantitative Water Permeability Mapping of Blood-Brain-Barrier Dysfunction in Aging
Blood-brain-barrier (BBB) dysfunction is a hallmark of aging and aging-related disorders, including cerebral small vessel disease and Alzheimer’s disease. An emerging biomarker of BBB dysfunction is BBB water exchange rate (k W ) as measured by diffusion-weighted arterial spin labeling (DW-ASL) MRI....
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| Published in: | Frontiers in aging neuroscience Vol. 14; p. 867452 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Switzerland
Frontiers Media S.A
08.04.2022
|
| Subjects: | |
| ISSN: | 1663-4365, 1663-4365 |
| Online Access: | Get full text |
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| Summary: | Blood-brain-barrier (BBB) dysfunction is a hallmark of aging and aging-related disorders, including cerebral small vessel disease and Alzheimer’s disease. An emerging biomarker of BBB dysfunction is BBB water exchange rate (k
W
) as measured by diffusion-weighted arterial spin labeling (DW-ASL) MRI. We developed an improved DW-ASL sequence for Quantitative Permeability Mapping and evaluated whole brain and region-specific k
W
in a cohort of 30 adults without dementia across the age spectrum. In this cross-sectional study, we found higher k
W
values in the cerebral cortex (mean = 81.51 min
–1
,
SD
= 15.54) compared to cerebral white matter (mean = 75.19 min
–1
,
SD
= 13.85) (
p
< 0.0001). We found a similar relationship for cerebral blood flow (CBF), concordant with previously published studies. Multiple linear regression analysis with k
W
as an outcome showed that age was statistically significant in the cerebral cortex (
p
= 0.013), cerebral white matter (
p
= 0.033), hippocampi (
p
= 0.043), orbitofrontal cortices (
p
= 0.042), and precunei cortices (
p
= 0.009), after adjusting for sex and number of vascular risk factors. With CBF as an outcome, age was statistically significant only in the cerebral cortex (
p
= 0.026) and precunei cortices (
p
= 0.020). We further found moderate negative correlations between white matter hyperintensity (WMH) k
W
and WMH volume (
r
= −0.51,
p
= 0.02), and normal-appearing white matter (NAWM) and WMH volume (
r
= −0.44,
p
= 0.05). This work illuminates the relationship between BBB water exchange and aging and may serve as the basis for BBB-targeted therapies for aging-related brain disorders. |
|---|---|
| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Alzheimer’s Disease and Related Dementias, a section of the journal Frontiers in Aging Neuroscience Edited by: Eszter Farkas, University of Szeged, Hungary Reviewed by: Alon Friedman, Dalhousie University, Canada; Donald Elbert, The University of Texas at Austin, United States; Istvan Krizbai, Hungarian Academy of Sciences (MTA), Hungary |
| ISSN: | 1663-4365 1663-4365 |
| DOI: | 10.3389/fnagi.2022.867452 |