A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP

Long-lasting changes in synaptic strength are thought to play a pivotal role in activity-dependent plasticity and memory. There is ample evidence indicating that in hippocampal long-term potentiation (LTP) the synthesis of new proteins is crucial for enduring changes. However, whether protein degrad...

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Vydané v:	Neuron (Cambridge, Mass.) Ročník 52; číslo 2; s. 239
Hlavní autori:	Fonseca, Rosalina, Vabulas, Ramunas M, Hartl, F Ulrich, Bonhoeffer, Tobias, Nägerl, U Valentin
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 19.10.2006
Predmet:	Amino Acids - metabolism Animals Enzyme Inhibitors - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Hippocampus - drug effects Hippocampus - metabolism Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Nerve Tissue Proteins - biosynthesis Organ Culture Techniques Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Proteasome Endopeptidase Complex - drug effects Proteasome Endopeptidase Complex - metabolism Protein Synthesis Inhibitors - pharmacology Rats Rats, Wistar Synaptic Transmission - drug effects Synaptic Transmission - physiology Ubiquitin - metabolism
ISSN:	0896-6273
On-line prístup:	Zistit podrobnosti o prístupe
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