Cerebral microbleeds: a guide to detection and interpretation

Cerebral microbleeds (CMBs) are increasingly recognised neuroimaging findings in individuals with cerebrovascular disease and dementia, and in normal ageing. There has been substantial progress in the understanding of CMBs in recent years, particularly in the development of newer MRI methods for the...

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Vydáno v:	Lancet neurology Ročník 8; číslo 2; s. 165 - 174
Hlavní autoři:	Greenberg, Steven M, Vernooij, Meike W, Cordonnier, Charlotte, Viswanathan, Anand, Al-Shahi Salman, Rustam, Warach, Steven, Launer, Lenore J, Van Buchem, Mark A, Breteler, Monique MB
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 01.02.2009 Elsevier Limited
Témata:	Aged Aging Cerebral Hemorrhage - diagnosis Cerebral Hemorrhage - epidemiology Cerebral Hemorrhage - pathology Cerebrovascular diseases Dementia disorders Fourier transforms Geriatrics Humans Image Processing, Computer-Assisted Magnetic fields Magnetic Resonance Imaging Neuroimaging Neurology Older people Population-based studies spatial discrimination
ISSN:	1474-4422, 1474-4465
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Abstract	Cerebral microbleeds (CMBs) are increasingly recognised neuroimaging findings in individuals with cerebrovascular disease and dementia, and in normal ageing. There has been substantial progress in the understanding of CMBs in recent years, particularly in the development of newer MRI methods for the detection of CMBs and the application of these techniques to population-based samples of elderly people. In this Review, we focus on these recent developments and their effects on two main questions: how CMBs are detected, and how CMBs should be interpreted. The number of CMBs detected depends on MRI characteristics, such as pulse sequence, sequence parameters, spatial resolution, magnetic field strength, and image post-processing, emphasising the importance of taking into account MRI technique in the interpretation of study results. Recent investigations with sensitive MRI techniques have indicated a high prevalence of CMBs in community-dwelling elderly people. We propose a procedural guide for identification of CMBs and suggest possible future approaches for elucidating the role of these common lesions as markers for, and contributors to, small-vessel brain disease.
AbstractList	Cerebral microbleeds (CMBs) are increasingly recognised neuroimaging findings in individuals with cerebrovascular disease and dementia, and in normal ageing. There has been substantial progress in the understanding of CMBs in recent years, particularly in the development of newer MRI methods for the detection of CMBs and the application of these techniques to population-based samples of elderly people. In this Review, we focus on these recent developments and their effects on two main questions: how CMBs are detected, and how CMBs should be interpreted. The number of CMBs detected depends on MRI characteristics, such as pulse sequence, sequence parameters, spatial resolution, magnetic field strength, and image post-processing, emphasising the importance of taking into account MRI technique in the interpretation of study results. Recent investigations with sensitive MRI techniques have indicated a high prevalence of CMBs in community-dwelling elderly people. We propose a procedural guide for identification of CMBs and suggest possible future approaches for elucidating the role of these common lesions as markers for, and contributors to, small-vessel brain disease. Summary Cerebral microbleeds (CMBs) are increasingly recognised neuroimaging findings in individuals with cerebrovascular disease and dementia, and in normal ageing. There has been substantial progress in the understanding of CMBs in recent years, particularly in the development of newer MRI methods for the detection of CMBs and the application of these techniques to population-based samples of elderly people. In this Review, we focus on these recent developments and their effects on two main questions: how CMBs are detected, and how CMBs should be interpreted. The number of CMBs detected depends on MRI characteristics, such as pulse sequence, sequence parameters, spatial resolution, magnetic field strength, and image post-processing, emphasising the importance of taking into account MRI technique in the interpretation of study results. Recent investigations with sensitive MRI techniques have indicated a high prevalence of CMBs in community-dwelling elderly people. We propose a procedural guide for identification of CMBs and suggest possible future approaches for elucidating the role of these common lesions as markers for, and contributors to, small-vessel brain disease. Cerebral microbleeds (CMBs) are increasingly recognised neuroimaging findings in individuals with cerebrovascular disease and dementia, and in normal ageing. There has been substantial progress in the understanding of CMBs in recent years, particularly in the development of newer MRI methods for the detection of CMBs and the application of these techniques to population-based samples of elderly people. In this Review, we focus on these recent developments and their effects on two main questions: how CMBs are detected, and how CMBs should be interpreted. The number of CMBs detected depends on MRI characteristics, such as pulse sequence, sequence parameters, spatial resolution, magnetic field strength, and image post-processing, emphasising the importance of taking into account MRI technique in the interpretation of study results. Recent investigations with sensitive MRI techniques have indicated a high prevalence of CMBs in community-dwelling elderly people. We propose a procedural guide for identification of CMBs and suggest possible future approaches for elucidating the role of these common lesions as markers for, and contributors to, small-vessel brain disease.Cerebral microbleeds (CMBs) are increasingly recognised neuroimaging findings in individuals with cerebrovascular disease and dementia, and in normal ageing. There has been substantial progress in the understanding of CMBs in recent years, particularly in the development of newer MRI methods for the detection of CMBs and the application of these techniques to population-based samples of elderly people. In this Review, we focus on these recent developments and their effects on two main questions: how CMBs are detected, and how CMBs should be interpreted. The number of CMBs detected depends on MRI characteristics, such as pulse sequence, sequence parameters, spatial resolution, magnetic field strength, and image post-processing, emphasising the importance of taking into account MRI technique in the interpretation of study results. Recent investigations with sensitive MRI techniques have indicated a high prevalence of CMBs in community-dwelling elderly people. We propose a procedural guide for identification of CMBs and suggest possible future approaches for elucidating the role of these common lesions as markers for, and contributors to, small-vessel brain disease.
Author	Van Buchem, Mark A Breteler, Monique MB Greenberg, Steven M Vernooij, Meike W Warach, Steven Viswanathan, Anand Launer, Lenore J Cordonnier, Charlotte Al-Shahi Salman, Rustam
Author_xml	– sequence: 1 givenname: Steven M surname: Greenberg fullname: Greenberg, Steven M email: sgreenberg@partners.org organization: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA – sequence: 2 givenname: Meike W surname: Vernooij fullname: Vernooij, Meike W organization: Department of Radiology, Erasmus MC University Medical Center, Rotterdam, Netherlands – sequence: 3 givenname: Charlotte surname: Cordonnier fullname: Cordonnier, Charlotte organization: Department of Neurology (Stroke Department), Lille University Hospital, Lille, France – sequence: 4 givenname: Anand surname: Viswanathan fullname: Viswanathan, Anand organization: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA – sequence: 5 givenname: Rustam surname: Al-Shahi Salman fullname: Al-Shahi Salman, Rustam organization: Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK – sequence: 6 givenname: Steven surname: Warach fullname: Warach, Steven organization: Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, USA – sequence: 7 givenname: Lenore J surname: Launer fullname: Launer, Lenore J organization: Laboratory of Epidemiology, Biometry, and Demography, National Institute on Aging, Bethesda, USA – sequence: 8 givenname: Mark A surname: Van Buchem fullname: Van Buchem, Mark A organization: Department of Radiology, Leiden University Medical Center, Leiden, Netherlands – sequence: 9 givenname: Monique MB surname: Breteler fullname: Breteler, Monique MB organization: Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands
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Snippet	Cerebral microbleeds (CMBs) are increasingly recognised neuroimaging findings in individuals with cerebrovascular disease and dementia, and in normal ageing.... Summary Cerebral microbleeds (CMBs) are increasingly recognised neuroimaging findings in individuals with cerebrovascular disease and dementia, and in normal...
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SubjectTerms	Aged Aging Cerebral Hemorrhage - diagnosis Cerebral Hemorrhage - epidemiology Cerebral Hemorrhage - pathology Cerebrovascular diseases Dementia disorders Fourier transforms Geriatrics Humans Image Processing, Computer-Assisted Magnetic fields Magnetic Resonance Imaging Neuroimaging Neurology Older people Population-based studies spatial discrimination
Title	Cerebral microbleeds: a guide to detection and interpretation
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