Cerebral microbleeds: a guide to detection and interpretation

Cerebral microbleeds (CMBs) are increasingly recognised neuroimaging findings in individuals with cerebrovascular disease and dementia, and in normal ageing. There has been substantial progress in the understanding of CMBs in recent years, particularly in the development of newer MRI methods for the...

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Veröffentlicht in:Lancet neurology Jg. 8; H. 2; S. 165 - 174
Hauptverfasser: Greenberg, Steven M, Vernooij, Meike W, Cordonnier, Charlotte, Viswanathan, Anand, Al-Shahi Salman, Rustam, Warach, Steven, Launer, Lenore J, Van Buchem, Mark A, Breteler, Monique MB
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 01.02.2009
Elsevier Limited
Schlagworte:
Aged
Aging
Cerebral Hemorrhage - diagnosis
Cerebral Hemorrhage - epidemiology
Cerebral Hemorrhage - pathology
Cerebrovascular diseases
Dementia disorders
Fourier transforms
Geriatrics
Humans
Image Processing, Computer-Assisted
Magnetic fields
Magnetic Resonance Imaging
Neuroimaging
Neurology
Older people
Population-based studies
spatial discrimination
ISSN:1474-4422, 1474-4465
Online-Zugang:Volltext
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Zusammenfassung:Cerebral microbleeds (CMBs) are increasingly recognised neuroimaging findings in individuals with cerebrovascular disease and dementia, and in normal ageing. There has been substantial progress in the understanding of CMBs in recent years, particularly in the development of newer MRI methods for the detection of CMBs and the application of these techniques to population-based samples of elderly people. In this Review, we focus on these recent developments and their effects on two main questions: how CMBs are detected, and how CMBs should be interpreted. The number of CMBs detected depends on MRI characteristics, such as pulse sequence, sequence parameters, spatial resolution, magnetic field strength, and image post-processing, emphasising the importance of taking into account MRI technique in the interpretation of study results. Recent investigations with sensitive MRI techniques have indicated a high prevalence of CMBs in community-dwelling elderly people. We propose a procedural guide for identification of CMBs and suggest possible future approaches for elucidating the role of these common lesions as markers for, and contributors to, small-vessel brain disease.
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ISSN:1474-4422
1474-4465
DOI:10.1016/S1474-4422(09)70013-4