N-Nitrosodimethylamine Contamination in the Metformin Finished Products

A GC–MS/MS method with EI ionization was developed and validated to detect and quantify N-nitrosodimethylamine (NDMA) and seven other nitrosamines in 105 samples of metformin tablets from 13 different manufactures. Good linearity for each compound was demonstrated over the calibration range of 0.5–9...

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Vydané v:	Molecules (Basel, Switzerland) Ročník 25; číslo 22; s. 5304
Hlavní autori:	Zmysłowski, Adam, Książek, Iza, Szterk, Arkadiusz
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland MDPI 13.11.2020 MDPI AG
Predmet:	Calibration Dimethylnitrosamine - chemistry Drug Contamination Drug Design Europe Gas Chromatography-Mass Spectrometry GC-MS Limit of Detection Linear Models metformin Metformin - analysis Metformin - chemistry NDMA nitrosamines Pharmaceutical Preparations - analysis Powders Solvents Tablets Tandem Mass Spectrometry Temperature Europe GC-MS metformin nitrosamines NDMA
ISSN:	1420-3049, 1420-3049
On-line prístup:	Získať plný text
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