N-Nitrosodimethylamine Contamination in the Metformin Finished Products

A GC–MS/MS method with EI ionization was developed and validated to detect and quantify N-nitrosodimethylamine (NDMA) and seven other nitrosamines in 105 samples of metformin tablets from 13 different manufactures. Good linearity for each compound was demonstrated over the calibration range of 0.5–9...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 25; no. 22; p. 5304
Main Authors:	Zmysłowski, Adam, Książek, Iza, Szterk, Arkadiusz
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI 13.11.2020 MDPI AG
Subjects:	Calibration Dimethylnitrosamine - chemistry Drug Contamination Drug Design Europe Gas Chromatography-Mass Spectrometry GC-MS Limit of Detection Linear Models metformin Metformin - analysis Metformin - chemistry NDMA nitrosamines Pharmaceutical Preparations - analysis Powders Solvents Tablets Tandem Mass Spectrometry Temperature Europe GC-MS metformin nitrosamines NDMA
ISSN:	1420-3049, 1420-3049
Online Access:	Get full text
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