Precise HER2 Protein Degradation via Peptide‐Conjugated Photodynamic Therapy for Enhanced Breast Cancer Immunotherapy

Breast cancer, the most prevalent malignancy among women, frequently exhibits high HER2 expression, making HER2 a critical therapeutic target. Traditional treatments combining the anti‐HER2 antibody trastuzumab with immunotherapy face limitations due to toxicity and tumor microenvironment immunosupp...

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Bibliographic Details
Published in:	Advanced science Vol. 12; no. 2; pp. e2410778 - n/a
Main Authors:	Guo, Changyong, Gao, Fei, Wu, Guoyuan, Li, Jinqiu, Sheng, Chunquan, He, Shipeng, Hu, Honggang
Format:	Journal Article
Language:	English
Published:	Germany John Wiley & Sons, Inc 01.01.2025 John Wiley and Sons Inc Wiley
Subjects:	Animals Antibodies Antigens Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - immunology Breast Neoplasms - metabolism Breast Neoplasms - therapy Cancer therapies Cell Line, Tumor Chlorophyll - analogs & derivatives Chlorophyll - pharmacology Cytotoxicity Drug development Drug resistance Female gelatinase responsive peptides Humans immune induction Immunotherapy Immunotherapy - methods Lymphocytes Mice Mice, Inbred BALB C Morphology Nanomaterials Nanoparticles Nanoparticles - chemistry Peptides Phase transitions Photochemotherapy - methods Photodegradation photodynamic immunotherapy Photosensitizing Agents - pharmacology photo‐controlled her2 protein degradation Physiology Proteins Reactive Oxygen Species - metabolism Receptor, ErbB-2 - metabolism photo‐controlled her2 protein degradation breast cancer gelatinase responsive peptides immune induction photodynamic immunotherapy
ISSN:	2198-3844, 2198-3844
Online Access:	Get full text
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