Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury

Monocyte/macrophage recruitment correlates strongly with the progression of diabetic nephropathy. Tumor necrosis factor-α (TNF-α) is produced by monocytes/macrophages but the direct role of TNF-α and/or macrophage-derived TNF-α in the progression of diabetic nephropathy remains unclear. Here we test...

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Bibliographic Details
Published in:	Kidney international Vol. 88; no. 4; pp. 722 - 733
Main Authors:	Awad, Alaa S., You, Hanning, Gao, Ting, Cooper, Timothy K., Nedospasov, Sergei A., Vacher, Jean, Wilkinson, Patrick F., Farrell, Francis X., Brian Reeves, W.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.10.2015
Subjects:	albuminuria Albuminuria - genetics Albuminuria - metabolism Albuminuria - prevention & control Animals Antibodies, Neutralizing - pharmacology Biomarkers - blood Blood Urea Nitrogen CD11b Antigen - genetics CD11b Antigen - metabolism Chemotaxis Creatinine - blood Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic Nephropathies - prevention & control diabetic nephropathy Genetic Predisposition to Disease inflammation Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - metabolism Kidney - drug effects Kidney - metabolism Kidney - pathology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Macrophages, Peritoneal - pathology Male Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout Phenotype Receptors, Tumor Necrosis Factor, Type I - metabolism Receptors, Tumor Necrosis Factor, Type II - metabolism Signal Transduction Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - deficiency Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism albuminuria inflammation diabetic nephropathy
ISSN:	0085-2538, 1523-1755, 1523-1755
Online Access:	Get full text
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