Dysregulated Class I histone deacetylases are indicators of poor prognosis in multiple myeloma

Histone deacetylases (HDAC) control gene expression through their ability to acetylate proteins, thereby influencing a diverse range of cellular functions. Class I HDAC (HDAC1-3 and 8) and HDAC6 are predominantly upregulated in malignancies and their altered expression in some cancers has a signific...

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Vydáno v:	Epigenetics Ročník 9; číslo 11; s. 1511 - 1520
Hlavní autoři:	Mithraprabhu, Sridurga, Kalff, Anna, Chow, Annie, Khong, Tiffany, Spencer, Andrew
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Taylor & Francis 02.11.2014
Témata:	Cell Line, Tumor Class I HDAC Disease-Free Survival Gene Expression Regulation, Neoplastic HDAC expression hematological malignancy Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Histone Deacetylase 6 histone deacetylases Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans Immunohistochemistry multiple myeloma Multiple Myeloma - enzymology Multiple Myeloma - genetics Multiple Myeloma - mortality Predictive Value of Tests Prognosis Reference Values Research Paper multiple myeloma histone deacetylases hematological malignancy Class I HDAC prognosis HDAC expression
ISSN:	1559-2294, 1559-2308, 1559-2308
On-line přístup:	Získat plný text
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