Stage-specific dynamic reorganization of genome topology shapes transcriptional neighborhoods in developing human retinal organoids

We have generated a high-resolution Hi-C map of developing human retinal organoids to elucidate spatiotemporal dynamics of genomic architecture and its relationship with gene expression patterns. We demonstrate progressive stage-specific alterations in DNA topology and correlate these changes with t...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 42; H. 12; S. 113543
Hauptverfasser:	Qu, Zepeng, Batz, Zachary, Singh, Nivedita, Marchal, Claire, Swaroop, Anand
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 26.12.2023 Elsevier
Schlagworte:	3D chromatin structure Cell Differentiation - genetics Chromatin chromatin looping CP: Neuroscience CP: Stem cell research gene regulation Genome Hi-C Humans organogenesis organoid Organoids Retina retinal development stem cells topologically associated domains transcription factor stem cells transcription factor CP: Stem cell research chromatin looping Hi-C gene regulation CP: Neuroscience 3D chromatin structure retinal development organogenesis organoid topologically associated domains
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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