Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure

Genome-wide association studies (GWASs) have identified numerous variants associated with polygenic traits and diseases. However, with few exceptions, a mechanistic understanding of which variants affect which genes in which tissues to modulate trait variation is lacking. Here, we present genomic an...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 42; no. 11; p. 113351
Main Authors:	Lee, Dongwon, Han, Seong Kyu, Yaacov, Or, Berk-Rauch, Hanna, Mathiyalagan, Prabhu, Ganesh, Santhi K., Chakravarti, Aravinda
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 28.11.2023 Elsevier
Subjects:	blood pressure Blood Pressure - genetics complex traits CP: Genomics Gene Expression Regulation Gene Regulatory Networks Genetic Variation Genome-Wide Association Study heritability Humans Phenotype Polymorphism, Single Nucleotide - genetics Quantitative Trait Loci - genetics regulatory variants transcriptional machinery blood pressure complex traits transcriptional machinery CP: Genomics regulatory variants heritability
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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