Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites

The murine Igh locus has a 3' regulatory region (3' RR) containing four enhancers (hs3A, hs1,2, hs3B, and hs4) at DNase I-hypersensitive sites. The 3' RR exerts long-range effects on class switch recombination (CSR) to several isotypes through its control of germ line transcription. B...

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Veröffentlicht in:	Molecular and cellular biology Jg. 25; H. 4; S. 1511
Hauptverfasser:	Garrett, Francine E, Emelyanov, Alexander V, Sepulveda, Manuel A, Flanagan, Patrick, Volpi, Sabrina, Li, Fubin, Loukinov, Dmitry, Eckhardt, Laurel A, Lobanenkov, Victor V, Birshtein, Barbara K
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.02.2005
Schlagworte:	3' Flanking Region - genetics Acetylation - drug effects Animals B-Lymphocytes - immunology B-Lymphocytes - metabolism Bone Marrow - immunology Bone Marrow - metabolism CCCTC-Binding Factor Chromatin - genetics Chromatin - immunology Chromatin - metabolism Deoxyribonuclease I - metabolism DNA Primers - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology DNA-Binding Proteins - metabolism Enhancer Elements, Genetic - genetics Histones - genetics Histones - immunology Histones - metabolism Immunoglobulin Class Switching - drug effects Immunoglobulin Class Switching - genetics Immunoglobulin Class Switching - immunology Lipopolysaccharides - pharmacology Locus Control Region - genetics Mice Repressor Proteins - genetics Repressor Proteins - immunology Repressor Proteins - metabolism Spleen - immunology Spleen - metabolism Transcription, Genetic - genetics
ISSN:	0270-7306
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