REV7 directs DNA repair pathway choice

REV7 is a small multifunctional protein that participates in multiple DNA repair pathways, most notably translesion DNA synthesis and double-strand break (DSB) repair. While the role of REV7 in translesion synthesis has been known for several decades, its function in DSB repair is a recent discovery...

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Bibliographic Details
Published in:	Trends in cell biology Vol. 31; no. 12; pp. 965 - 978
Main Authors:	Clairmont, Connor S., D’Andrea, Alan D.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.12.2021 Elsevier BV
Subjects:	ATPases Associated with Diverse Cellular Activities - genetics ATPases Associated with Diverse Cellular Activities - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA Repair DNA Replication Domains Double-strand break repair Fanconi anemia Mad2 Proteins - genetics Mad2 Proteins - metabolism Repair Replication forks REV7 Shieldin Synthesis translesion synthesis TRIP13 Yeast REV7 Fanconi anemia Shieldin double-strand break repair TRIP13 DNA repair translesion synthesis
ISSN:	0962-8924, 1879-3088, 1879-3088
Online Access:	Get full text
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