Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice

Neutrophil extracellular traps (NETs; webs of DNA coated in antimicrobial proteins) are released into the vasculature during sepsis where they contribute to host defense, but also cause tissue damage and organ dysfunction. Various components of NETs have also been implicated as activators of coagula...

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Bibliographic Details

Published in:	Blood Vol. 129; no. 10; p. 1357
Main Authors:	McDonald, Braedon, Davis, Rachelle P, Kim, Seok-Joo, Tse, Mandy, Esmon, Charles T, Kolaczkowska, Elzbieta, Jenne, Craig N
Format:	Journal Article
Language:	English
Published:	United States 09.03.2017
Subjects:	Animals Blood Platelets - immunology Disease Models, Animal Disseminated Intravascular Coagulation - immunology Extracellular Traps - immunology Mice Mice, Inbred C57BL Microscopy, Confocal Sepsis - immunology
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
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