Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML

There is interest in using leukemia-gene panels and next-generation sequencing to assess acute myelogenous leukemia (AML) response to induction chemotherapy. Studies have shown that patients with AML in morphologic remission may continue to have clonal hematopoiesis with populations closely related...

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Vydáno v:	Blood Ročník 127; číslo 7; s. 893
Hlavní autoři:	Wong, Terrence N, Miller, Christopher A, Klco, Jeffery M, Petti, Allegra, Demeter, Ryan, Helton, Nichole M, Li, Tiandao, Fulton, Robert S, Heath, Sharon E, Mardis, Elaine R, Westervelt, Peter, DiPersio, John F, Walter, Matthew J, Welch, John S, Graubert, Timothy A, Wilson, Richard K, Ley, Timothy J, Link, Daniel C
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 18.02.2016
Témata:	Aging - genetics Aging - metabolism Aging - pathology Cells, Cultured Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology High-Throughput Nucleotide Sequencing Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Mutation Recurrence
ISSN:	1528-0020, 1528-0020
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