Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project

One recently identified subtype of pediatric B-precursor acute lymphoblastic leukemia (ALL) has been termed BCR-ABL1-like or Ph-like because of similarity of the gene expression profile to BCR-ABL1 positive ALL suggesting the presence of lesions activating tyrosine kinases, frequent alteration of IK...

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Veröffentlicht in:	Blood Jg. 121; H. 3; S. 485
Hauptverfasser:	Loh, Mignon L, Zhang, Jinghui, Harvey, Richard C, Roberts, Kathryn, Payne-Turner, Debbie, Kang, Huining, Wu, Gang, Chen, Xiang, Becksfort, Jared, Edmonson, Michael, Buetow, Kenneth H, Carroll, William L, Chen, I-Ming, Wood, Brent, Borowitz, Michael J, Devidas, Meenakshi, Gerhard, Daniela S, Bowman, Paul, Larsen, Eric, Winick, Naomi, Raetz, Elizabeth, Smith, Malcolm, Downing, James R, Willman, Cheryl L, Mullighan, Charles G, Hunger, Stephen P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.01.2013
Schlagworte:	Child Child, Preschool Disease-Free Survival Female fms-Like Tyrosine Kinase 3 - genetics fms-Like Tyrosine Kinase 3 - metabolism Gene Expression Regulation, Leukemic - physiology Humans Infant Janus Kinase 1 - genetics Janus Kinase 1 - metabolism Janus Kinase 2 - genetics Janus Kinase 2 - metabolism Male Neoplasm, Residual - enzymology Neoplasm, Residual - genetics Neoplasm, Residual - mortality Philadelphia Chromosome Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Receptors, Cytokine - genetics Receptors, Cytokine - metabolism Receptors, Purinergic P2Y - genetics Receptors, Purinergic P2Y - metabolism Signal Transduction - genetics Transcriptome
ISSN:	1528-0020, 1528-0020
Online-Zugang:	Weitere Angaben
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