PPM1D -truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

Truncating mutations in the terminal exon of protein phosphatase Mg2 /Mn2 1D ( ) have been identified in clonal hematopoiesis and myeloid neoplasms, with a striking enrichment in patients previously exposed to chemotherapy. In this study, we demonstrate that truncating mutations confer a chemoresist...

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Vydáno v:	Blood Ročník 132; číslo 11; s. 1095
Hlavní autoři:	Kahn, Josephine D, Miller, Peter G, Silver, Alexander J, Sellar, Rob S, Bhatt, Shruti, Gibson, Christopher, McConkey, Marie, Adams, Dylan, Mar, Brenton, Mertins, Philipp, Fereshetian, Shaunt, Krug, Karsten, Zhu, Haoling, Letai, Anthony, Carr, Steven A, Doench, John, Jaiswal, Siddhartha, Ebert, Benjamin L
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 13.09.2018
Témata:	Base Sequence Cell Line, Tumor CRISPR-Cas Systems Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Enzyme Inhibitors - pharmacology Hematologic Neoplasms - drug therapy Hematologic Neoplasms - enzymology Hematologic Neoplasms - genetics Hematologic Neoplasms - pathology Hematopoietic Stem Cells - enzymology Hematopoietic Stem Cells - pathology Humans Myeloproliferative Disorders - drug therapy Myeloproliferative Disorders - enzymology Myeloproliferative Disorders - genetics Myeloproliferative Disorders - pathology Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplastic Stem Cells - enzymology Neoplastic Stem Cells - pathology Protein Phosphatase 2C - antagonists & inhibitors Protein Phosphatase 2C - genetics Protein Phosphatase 2C - metabolism Sequence Deletion
ISSN:	1528-0020, 1528-0020
On-line přístup:	Zjistit podrobnosti o přístupu
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