Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a powerful platform for biomedical research. However, they are immature, which is a barrier to modeling adult-onset cardiovascular disease. Here, we sought to develop a simple method that could drive cultured hiPSC-CMs toward...

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Vydané v:	Stem cell reports Ročník 16; číslo 3; s. 519 - 533
Hlavní autori:	Knight, Walter E., Cao, Yingqiong, Lin, Ying-Hsi, Chi, Congwu, Bai, Betty, Sparagna, Genevieve C., Zhao, Yuanbiao, Du, Yanmei, Londono, Pilar, Reisz, Julie A., Brown, Benjamin C., Taylor, Matthew R.G., Ambardekar, Amrut V., Cleveland, Joseph C., McKinsey, Timothy A., Jeong, Mark Y., Walker, Lori A., Woulfe, Kathleen C., D'Alessandro, Angelo, Chatfield, Kathryn C., Xu, Hongyan, Bristow, Michael R., Buttrick, Peter M., Song, Kunhua
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 09.03.2021 Elsevier
Predmet:	cardiomyocyte maturation disease modeling HIF1α hiPSC-CM hiPSC-CM maturation hypertrophic cardiomyopathy hiPSC-CM maturation hypertrophic cardiomyopathy cardiomyocyte maturation hiPSC-CM HIF1α disease modeling
ISSN:	2213-6711, 2213-6711
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