Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a powerful platform for biomedical research. However, they are immature, which is a barrier to modeling adult-onset cardiovascular disease. Here, we sought to develop a simple method that could drive cultured hiPSC-CMs toward...

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Veröffentlicht in:	Stem cell reports Jg. 16; H. 3; S. 519 - 533
Hauptverfasser:	Knight, Walter E., Cao, Yingqiong, Lin, Ying-Hsi, Chi, Congwu, Bai, Betty, Sparagna, Genevieve C., Zhao, Yuanbiao, Du, Yanmei, Londono, Pilar, Reisz, Julie A., Brown, Benjamin C., Taylor, Matthew R.G., Ambardekar, Amrut V., Cleveland, Joseph C., McKinsey, Timothy A., Jeong, Mark Y., Walker, Lori A., Woulfe, Kathleen C., D'Alessandro, Angelo, Chatfield, Kathryn C., Xu, Hongyan, Bristow, Michael R., Buttrick, Peter M., Song, Kunhua
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 09.03.2021 Elsevier
Schlagworte:	cardiomyocyte maturation disease modeling HIF1α hiPSC-CM hiPSC-CM maturation hypertrophic cardiomyopathy hiPSC-CM maturation hypertrophic cardiomyopathy cardiomyocyte maturation hiPSC-CM HIF1α disease modeling
ISSN:	2213-6711, 2213-6711
Online-Zugang:	Volltext
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