α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of C-peptide long after disease onset but develop an inadequate glucagon response to hypoglycemia following T1D diagnosis. The features of these residual β cells and α cells in the islet endocrine compartment are...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 22; no. 10; pp. 2667 - 2676
Main Authors:	Brissova, Marcela, Haliyur, Rachana, Saunders, Diane, Shrestha, Shristi, Dai, Chunhua, Blodgett, David M., Bottino, Rita, Campbell-Thompson, Martha, Aramandla, Radhika, Poffenberger, Gregory, Lindner, Jill, Pan, Fong Cheng, von Herrath, Matthias G., Greiner, Dale L., Shultz, Leonard D., Sanyoura, May, Philipson, Louis H., Atkinson, Mark, Harlan, David M., Levy, Shawn E., Prasad, Nripesh, Stein, Roland, Powers, Alvin C.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 06.03.2018 Elsevier
Subjects:	Adolescent Adult alpha cells Animals Case-Control Studies Cellular Reprogramming Child Diabetes Mellitus, Type 1 - genetics Female Gene Expression Regulation glucagon Glucagon - metabolism Glucagon-Secreting Cells - metabolism Glucagon-Secreting Cells - pathology human Humans insulin Insulin Secretion Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Male Mice Middle Aged pancreatic islet Phenotype Tissue Donors Transcription Factors - metabolism type 1 diabetes Young Adult glucagon type 1 diabetes pancreatic islet insulin human alpha cells
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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