T Cell Activation Depends on Extracellular Alanine

T cell stimulation is metabolically demanding. To exit quiescence, T cells rely on environmental nutrients, including glucose and the amino acids glutamine, leucine, serine, and arginine. The expression of transporters for these nutrients is tightly regulated and required for T cell activation. In c...

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Bibliographic Details

Published in:	Cell reports (Cambridge) Vol. 28; no. 12; pp. 3011 - 3021.e4
Main Authors:	Ron-Harel, Noga, Ghergurovich, Jonathan M., Notarangelo, Giulia, LaFleur, Martin W., Tsubosaka, Yoshiki, Sharpe, Arlene H., Rabinowitz, Joshua D., Haigis, Marcia C.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 17.09.2019 Elsevier
Subjects:	alanine metabolism protein synthesis T cell activation T cells protein synthesis metabolism alanine T cell activation T cells
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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