Notch Signaling Mediates Secondary Senescence

Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation that can be transmitted to neighboring cells through secreted factors of the senescence-associated secretory phenotype (SASP). Currently, primary and secondary senescent cells are not considered functionally dis...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 27; no. 4; pp. 997 - 1007.e5
Main Authors:	Teo, Yee Voan, Rattanavirotkul, Nattaphong, Olova, Nelly, Salzano, Angela, Quintanilla, Andrea, Tarrats, Nuria, Kiourtis, Christos, Müller, Miryam, Green, Anthony R., Adams, Peter D., Acosta, Juan-Carlos, Bird, Thomas G., Kirschner, Kristina, Neretti, Nicola, Chandra, Tamir
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 23.04.2019 Cell Press
Subjects:	Animals bystander senescence CEBPB Cells, Cultured Cellular Senescence Humans Mice, Inbred C57BL Notch oncogene induced senescence Oncogenes - physiology paracrine senescence Receptors, Notch - metabolism Receptors, Notch - physiology secondary senescence senescence senescence associated secretory phenotype Signal Transduction Single-Cell Analysis single-cell RNA sequencing TGFB Transcriptome single-cell RNA sequencing senescence CEBPB secondary senescence senescence associated secretory phenotype Notch paracrine senescence TGFB oncogene induced senescence bystander senescence
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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