Curcumin Protects an SH-SY5Y Cell Model of Parkinson’s Disease Against Toxic Injury by Regulating HSP90

Background/Aims: We aimed to explore the protective role of curcumin (Cur) in a cell model of Parkinson’s disease (PD) and its underlying mechanism. Methods: In this study, genes concerned with PD-related keywords were screened within DiGSeE database. The association network between Cur and selected...

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Bibliographic Details
Published in:	Cellular physiology and biochemistry Vol. 51; no. 2; pp. 681 - 691
Main Authors:	Sang, Qiuling, Liu, Xiaoyang, Wang, Libo, Qi, Ling, Sun, Wenping, Wang, Weiyao, Sun, Yajuan , Zhang, Haina
Format:	Journal Article
Language:	English
Published:	Basel, Switzerland S. Karger AG 01.01.2018 Cell Physiol Biochem Press GmbH & Co KG
Subjects:	1-Methyl-4-phenylpyridinium - toxicity Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism bcl-X Protein - metabolism Cell Line, Tumor Cell Proliferation - drug effects Curcumin Curcumin - pharmacology Dopamine - analysis Dopamine Plasma Membrane Transport Proteins - metabolism Dopaminergic neurons Gene Regulatory Networks Heat shock proteins HSP90 HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism Humans Kinases Models, Biological Morphology MPP Neurodegeneration Original Paper Parkinson Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease RNA Interference RNA, Small Interfering - metabolism SH-SY5Y China Dopaminergic neurons HSP90 SH-SY5Y Curcumin MPP Parkinson
ISSN:	1015-8987, 1421-9778, 1421-9778
Online Access:	Get full text
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