The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

DNA-protein crosslinks (DPCs) are a specific type of DNA lesion in which proteins are covalently attached to DNA. Unrepaired DPCs lead to genomic instability, cancer, neurodegeneration, and accelerated aging. DPC proteolysis was recently identified as a specialized pathway for DPC repair. The DNA-de...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 37; no. 10; p. 110080
Main Authors:	Ruggiano, Annamaria, Vaz, Bruno, Kilgas, Susan, Popović, Marta, Rodriguez-Berriguete, Gonzalo, Singh, Abhay N., Higgins, Geoff S., Kiltie, Anne E., Ramadan, Kristijan
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 07.12.2021 Cell Press
Subjects:	BRCA deficiency DNA Breaks, Double-Stranded DNA Damage DNA Repair DNA Replication DNA, Neoplasm - biosynthesis DNA, Neoplasm - genetics DNA, Neoplasm - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-protein crosslink repair Female formaldehyde toxicity genome stability Genomic Instability HEK293 Cells HeLa Cells Homologous Recombination Humans Male Proteolysis SPRTN protease SUMO Sumoylation Synthetic Lethal Mutations synthetic lethality ubiquitin genome stability DNA replication SUMO homologous recombination DNA-protein crosslink repair SPRTN protease synthetic lethality formaldehyde toxicity BRCA deficiency ubiquitin
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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