PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia

Alterations of genes encoding transcriptional regulators of lymphoid development are a hallmark of B-progenitor acute lymphoblastic leukemia (B-ALL) and most commonly involve PAX5, encoding the DNA-binding transcription factor paired-box 5. The majority of PAX5 alterations in ALL are heterozygous, a...

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Vydáno v:	Blood Ročník 125; číslo 23; s. 3609
Hlavní autoři:	Dang, Jinjun, Wei, Lei, de Ridder, Jeroen, Su, Xiaoping, Rust, Alistair G, Roberts, Kathryn G, Payne-Turner, Debbie, Cheng, Jinjun, Ma, Jing, Qu, Chunxu, Wu, Gang, Song, Guangchun, Huether, Robert G, Schulman, Brenda, Janke, Laura, Zhang, Jinghui, Downing, James R, van der Weyden, Louise, Adams, David J, Mullighan, Charles G
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 04.06.2015
Témata:	Animals Gene Deletion Mice Mice, Mutant Strains Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology PAX5 Transcription Factor - genetics PAX5 Transcription Factor - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
ISSN:	1528-0020, 1528-0020
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