Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis

Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-epithelial transition (MET), are fundamental processes in embryonic development and tissue repair but confer malignant properties to carcinoma cells, including invasive behavior, cancer stem cell activity, and greate...

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Veröffentlicht in:Developmental cell Jg. 49; H. 3; S. 361
Hauptverfasser: Lu, Wei, Kang, Yibin
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 06.05.2019
Schlagworte:
Animals
Cell Plasticity - physiology
Cell Transformation, Neoplastic - pathology
Embryonic Development
Epithelial-Mesenchymal Transition - physiology
Fibroblasts - metabolism
Humans
Neoplasm Invasiveness - pathology
Neoplasm Metastasis - pathology
Neoplasms - metabolism
Neoplasms - pathology
Neoplastic Stem Cells - pathology
Neovascularization, Pathologic - pathology
cellular plasticity
chemoresistance
immune evasion
metastasis
stemness
epithelial-to-mesenchymal transition
ISSN:1878-1551, 1878-1551
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Zusammenfassung:Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-epithelial transition (MET), are fundamental processes in embryonic development and tissue repair but confer malignant properties to carcinoma cells, including invasive behavior, cancer stem cell activity, and greater resistance to chemotherapy and immunotherapy. Understanding the molecular and cellular basis of EMT provides fundamental insights into the etiology of cancer and may, in the long run, lead to new therapeutic strategies. Here, we discuss the regulatory mechanisms and pathological roles of epithelial-mesenchymal plasticity, with a focus on recent insights into the complexity and dynamics of this phenomenon in cancer.
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ObjectType-Review-3
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ISSN:1878-1551
1878-1551
DOI:10.1016/j.devcel.2019.04.010