AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice

Existing therapies for inflammatory bowel disease that are based on broad suppression of inflammation result in variable clinical benefit and unwanted side effects. A potential therapeutic approach for promoting immune tolerance is the in vivo induction of regulatory T cells (Tregs). Here we report...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell reports (Cambridge) Jg. 17; H. 5; S. 1318 - 1329
Hauptverfasser:	Goettel, Jeremy A., Gandhi, Roopali, Kenison, Jessica E., Yeste, Ada, Murugaiyan, Gopal, Sambanthamoorthy, Sharmila, Griffith, Alexandra E., Patel, Bonny, Shouval, Dror S., Weiner, Howard L., Snapper, Scott B., Quintana, Francisco J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 25.10.2016 Elsevier
Schlagworte:	AHR Animals Colitis - immunology Colitis - metabolism Disease Models, Animal Forkhead Transcription Factors - metabolism humanized mice Humans IBD ITE Mice Receptors, Aryl Hydrocarbon - metabolism T-Lymphocytes, Regulatory - immunology Thiazoles Transforming Growth Factor beta1 - pharmacology treg Trinitrobenzenesulfonic Acid IBD AHR ITE treg humanized mice
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!