Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group

Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subtype characterized by genomic alterations that activate cytokine receptor and kinase signaling. We examined the frequency and spectrum of targetable genetic lesions in a retrospective cohort of 1389 consecuti...

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Vydáno v:	Blood Ročník 129; číslo 25; s. 3352
Hlavní autoři:	Reshmi, Shalini C, Harvey, Richard C, Roberts, Kathryn G, Stonerock, Eileen, Smith, Amy, Jenkins, Heather, Chen, I-Ming, Valentine, Marc, Liu, Yu, Li, Yongjin, Shao, Ying, Easton, John, Payne-Turner, Debbie, Gu, Zhaohui, Tran, Thai Hoa, Nguyen, Jonathan V, Devidas, Meenakshi, Dai, Yunfeng, Heerema, Nyla A, Carroll, 3rd, Andrew J, Raetz, Elizabeth A, Borowitz, Michael J, Wood, Brent L, Angiolillo, Anne L, Burke, Michael J, Salzer, Wanda L, Zweidler-McKay, Patrick A, Rabin, Karen R, Carroll, William L, Zhang, Jinghui, Loh, Mignon L, Mullighan, Charles G, Willman, Cheryl L, Gastier-Foster, Julie M, Hunger, Stephen P
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 22.06.2017
Témata:	Child Female Fusion Proteins, bcr-abl - genetics Gene Expression Regulation, Leukemic Gene Fusion Humans Interleukin-7 Receptor alpha Subunit - genetics Janus Kinase 2 - genetics Male Mutation Philadelphia Chromosome Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Protein Kinases - genetics Receptors, Cytokine - genetics Retrospective Studies Transcriptome
ISSN:	1528-0020, 1528-0020
On-line přístup:	Zjistit podrobnosti o přístupu
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